Q1WR98 (Q1WR98_LACS1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase HAMAP MF_00214
Short name=3-dehydroquinase HAMAP MF_00214
EC=4.2.1.10 HAMAP MF_00214

Alternative name(s):
Type I DHQase HAMAP MF_00214

Gene names

Name:	aroD HAMAP MF_00214 EMBL ABE00600.1
Ordered Locus Names:	LSL_1796

Encoded on

Plasmid pMP118 EMBL ABE00600.1

Organism

Lactobacillus salivarius (strain UCC118) [Complete proteome] [HAMAP]

Taxonomic identifier

362948 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family. HAMAP MF_00214

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00214
Ligand	Schiff base HAMAP MF_00214 SAAS SAAS018508
Molecular function	Lyase HAMAP MF_00214 EMBL ABE00600.1
Technical term	Complete proteome Plasmid EMBL ABE00600.1
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	144	1	Proton acceptor By similarity HAMAP MF_00214
	Active site	171	1	Schiff-base intermediate with substrate By similarity HAMAP MF_00214

Sequences

	Sequence		Length	Mass (Da)
	Q1WR98 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 42C2A46F8243313B	FASTA	252	28,288
	10 20 30 40 50 60 MRIVKVRNVE FGTDRPKIAV PITGKSSDDI IKQAETIMSS DNADLIEWRI DFFDQVEDAE 70 80 90 100 110 120 KLVETAKKLR QVMGEMPLLT TFRTHFEGGV KELSEEEYFD ICRVLIKEKA TDLLDLELFR 130 140 150 160 170 180 KTSKLKEIIA EAHENNIYII MSNHDFDKTP ATSELERRLT LMKTYGADIA KIAVMPNSAR 190 200 210 220 230 240 DVLNLLLATD NMKYKLNCPL ITMAMGDLGK VTRISGEVFG SCLTFGTVGD ASAPGQIEST 250 NLKGILNTLK FD

References

[1]

"Multireplicon genome architecture of Lactobacillus salivarius." Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P., Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W. Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006) [PubMed: 16617113] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UCC118.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000234 Genomic DNA. Translation: ABE00600.1.
RefSeq	YP_536683.1. NC_007930.1.
3D structure databases
ProteinModelPortal	Q1WR98.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1WR98.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3978313.
GenomeReviews	Gene locus LSL_1796 in contig CP000234_GR.
KEGG	lsl:LSL_1796.
PATRIC	22280656. VBILacSal43464_1915.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0710.
HOGENOM	HBG732926.
OMA	IAKIAVM.
PhylomeDB	Q1WR98.
ProtClustDB	PRK02412.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR018508. 3-dehydroquinate_DH_AS. IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. AroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q1WR98_LACS1

Accession

Primary (citable) accession number: Q1WR98

Entry history

Integrated into UniProtKB/TrEMBL:	May 2, 2006
Last sequence update:	May 2, 2006
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)