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Q1WP02 (PA_I77AB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polymerase acidic protein
Alternative name(s):
RNA-directed RNA polymerase subunit P2
Gene names
Name:PA
OrganismInfluenza A virus (strain A/USSR/90/1977 H1N1) [Complete proteome]
Taxonomic identifier381516 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
Virus hostAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length716 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication By similarity.

Subunit structure

Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA By similarity.

Post-translational modification

Phosphorylated on serines and threonines by host kinases, including human casein kinase II By similarity.

Sequence similarities

Belongs to the influenza viruses PA family.

Alternative products

This entry describes 2 isoforms produced by ribosomal frameshifting. [Align] [Select]
Isoform PA (identifier: Q1WP02-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform PA-X (identifier: P0DJW7-1)

The sequence of this isoform can be found in the external entry P0DJW7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 716716Polymerase acidic protein
PRO_0000279267

Sequences

Sequence LengthMass (Da)Tools
Isoform PA [UniParc].

Last modified May 2, 2006. Version 1.
Checksum: A3FE2C274D3D20CB

FASTA71682,834
        10         20         30         40         50         60 
MEDFVRQCFN PMIVELAEKA MKEYGEDLKI ETNKFAAICT HLEVCFMYSD FHFINEQGES 

        70         80         90        100        110        120 
IIVELDDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTGA EKPKFLPDLY DYKENRFIEI 

       130        140        150        160        170        180 
GVTRREVHIY YLEKANKIKS EKTHIHIFSF TGEEMATKAD YTLDEESRAR IKTRLFTIRQ 

       190        200        210        220        230        240 
EMASRGLWDS FRQSERGEET IEERFEITGT MRRLADQSLP PNFSCLENFR AYVDGFEPNG 

       250        260        270        280        290        300 
YIEGKLSQMS KEVNARIEPF LKTTPRPIRL PDGPPCSQRS KFLLMDALKL SIEDPSHEGE 

       310        320        330        340        350        360 
GIPLYDAIKC MRTFFGWKEP YVVKPHEKGI NPNYLLSWKQ VLAELQDIEN EEKIPRTKNM 

       370        380        390        400        410        420 
KKTSQLKWAL GENMAPEKVD FDDCKDISDL KQYDSDEPEL RSLSSWIQNE FNKACELTDS 

       430        440        450        460        470        480 
IWIELDEIGE DVAPIEHIAS MRRNYFTAEV SHCRATEYIM KGVYINTALL NASCAAMDDF 

       490        500        510        520        530        540 
QLIPMISKCR TKEGRRKTNL YGFIIKGRSH LRNDTDVVNF VSMEFSLTDP RLEPHKWEKY 

       550        560        570        580        590        600 
CVLEIGDMLL RSAIGQVSRP MFLYVRTNGT SKIKMKWGME MRRCLLQSLQ QIESMIEAES 

       610        620        630        640        650        660 
SVKEKDMTKE FFENKSETWP IGESPKGVEE GSIGKVCRTL LAKSVFNSLY ASPQLEGFSA 

       670        680        690        700        710 
ESRKLLLVVQ ALRDNLEPGT FDLGGLYEAI EECLINDPWV LLNASWFNSF LTHALR 

« Hide

Isoform PA-X [UniParc].

See P0DJW7.

References

[1]"The NIAID influenza genome sequencing project."
Ghedin E., Spiro D., Miller N., Zaborsky J., Feldblyum T., Subbu V., Shumway M., Sparenborg J., Groveman L., Halpin R., Sitz J., Koo H., Salzberg S.L., Webster R.G., Hoffmann E., Krauss S., Naeve C., Bao Y. expand/collapse author list , Bolotov P., Dernovoy D., Kiryutin B., Lipman D.J., Tatusova T.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Complete genome sequencing and analysis of selected influenza virus vaccine strains spanning six decades (1933-1999)."
Mbawuike I.N., Zhang Y., Yamada R.E., Nino D., Bui H.-H., Sette A., Couch R.B.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CY010377 Genomic RNA. Translation: ABD95357.1.
DQ508896 Genomic RNA. Translation: ABF21263.1.

3D structure databases

ProteinModelPortalQ1WP02.
SMRQ1WP02. Positions 257-716.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001009. RNA-dir_pol_influenzavirus.
[Graphical view]
PfamPF00603. Flu_PA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePA_I77AB
AccessionPrimary (citable) accession number: Q1WP02
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: May 2, 2006
Last modified: April 16, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families