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Q1WP00 (PB1F2_I77AB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein PB1-F2
Gene names
Name:PB1
OrganismInfluenza A virus (strain A/USSR/90/1977 H1N1) [Complete proteome]
Taxonomic identifier381516 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
Virus hostAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length57 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. May also act in trans: extracellular PB1-F2 released by infected cells could potentially inactivate hosts cell recruitment to the site of infection. During early stage of infection, may predispose the mitochondria to permeability transition through interaction with human SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis By similarity.

Subunit structure

Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1 By similarity.

Subcellular location

Host mitochondrion inner membrane By similarity. Host nucleus By similarity. Host cytoplasmhost cytosol By similarity. Note: Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol By similarity.

Miscellaneous

Is not encoded in all strains, and seems to be dispensable for replication.

Sequence similarities

Belongs to the influenza viruses PB1-F2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5757Protein PB1-F2
PRO_0000278727

Sequences

Sequence LengthMass (Da)Tools
Q1WP00 [UniParc].

Last modified May 2, 2006. Version 1.
Checksum: F640088800E69BA2

FASTA576,540
        10         20         30         40         50 
MGQEQGTPWI QSTGHISTQK GEDGQKTPKL EHRNSTRLMG HYQKTMNQVV MPKQIVY 

« Hide

References

[1]"The NIAID influenza genome sequencing project."
Ghedin E., Spiro D., Miller N., Zaborsky J., Feldblyum T., Subbu V., Shumway M., Sparenborg J., Groveman L., Halpin R., Sitz J., Koo H., Salzberg S.L., Webster R.G., Hoffmann E., Krauss S., Naeve C., Bao Y. expand/collapse author list , Bolotov P., Dernovoy D., Kiryutin B., Lipman D.J., Tatusova T.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CY010378 Genomic RNA. Translation: ABD95359.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR021045. Flu_proapoptotic_PB1-F2.
[Graphical view]
PfamPF11986. PB1-F2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePB1F2_I77AB
AccessionPrimary (citable) accession number: Q1WP00
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 2, 2006
Last modified: April 16, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families