Reviewed, UniProtKB/Swiss-Prot Q1WNP0 (DHB1_PANTR)

Names and origin

Protein names

Recommended name:
    Estradiol 17-beta-dehydrogenase 1
    EC=1.1.1.62
Alternative name(s):
    17-beta-hydroxysteroid dehydrogenase type 1
      Short name=17-beta-HSD 1

Gene names

Name:

HSD17B1

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
Catalytic activity	Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.
Pathway	Steroid biosynthesis; estrogen biosynthesis.
Subunit structure	Homodimer By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Lipid synthesis Steroid biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	estrogen biosynthetic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	binding Inferred from electronic annotation. Source: InterPro estradiol 17-beta-dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 328	327	Estradiol 17-beta-dehydrogenase 1		PRO_0000251152
Regions
	Nucleotide binding	10 – 38	29	NADP By similarity
Sites
	Active site	156	1	Proton acceptor By similarity
	Binding site	66	1	NADP By similarity
	Binding site	143	1	Substrate By similarity
	Binding site	160	1	NADP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1WNP0-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: D390680343130598	FASTA	328	34,889
	10 20 30 40 50 60 MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA RALACPPGSL 70 80 90 100 110 120 ETLQLDVRDS KSVAAARERV TEGRVDVLVC NAGLGLLGPL EALGEDAVAS VLDVNVVGTV 130 140 150 160 170 180 RVLQAFLPDM KRRGSGRVLV TGSVGGLMGL PFNDVYCASK FALEGLCESL AVLLLPFGVH 190 200 210 220 230 240 LSLIECGPVH TAFMEKVLGS PEEVLDRTDI HTFHRFYQYL AHSKQVFREA AQNPEEVAEV 250 260 270 280 290 300 FLTALRAPKP TLRYFTTERF LPLLRMRLDD PSGSNYVTAM HREVFGDVPA KAEAGAEAGG 310 320 GAGPGAEDEA GPSAVGDPEL GDPPAAPQ

References

[1]

"Interspecies comparison of gene structure and computational analysis of gene regulation of 17beta-hydroxysteroid dehydrogenase type 1." Keller B., Ohnesorg T., Mindnich R., Gloeckner C.J., Breitling R., Scharfe M., Moeller G., Bloecker H., Adamski J. Mol. Cell. Endocrinol. 248:168-171(2006) [PubMed: 16337734] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ023266 Genomic DNA. Translation: AAZ22356.1.
3D structure databases
SMR	Q1WNP0. Positions 1-285, 2-286.
ModBase	Search...
Genome annotation databases
Ensembl	ENSPTRG00000009205. Pan troglodytes. [Contig view]
Phylogenomic databases
HOVERGEN	Q1WNP0.
Family and domain databases
InterPro	IPR011348. 17beta_DHase. IPR002198. DHase_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410:SF47. 17beta_DH. 1 hit. PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PIRSF	PIRSF000095. 17beta-HSD. 1 hit.
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHB1_PANTR

Accession

Primary (citable) accession number: Q1WNP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 25 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)