Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot Q1WNP0 (DHB1_PANTR)

Last modified November 25, 2008. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Estradiol 17-beta-dehydrogenase 1
    EC=1.1.1.62
Alternative name(s):
    17-beta-hydroxysteroid dehydrogenase type 1
      Short name=17-beta-HSD 1
Gene names
Name: HSD17B1
OrganismPan troglodytes (Chimpanzee)
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

Catalytic activity

Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.

Pathway

Steroid biosynthesis; estrogen biosynthesis.

Subunit structure

Homodimer By similarity.

Subcellular location

CytoplasmBy similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords

   Biological processLipid synthesis
Steroid biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase

Gene Ontology (GO)

   Biological processestrogen biosynthetic process

Inferred from electronic annotation. Source: InterPro

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular functionbinding

Inferred from electronic annotation. Source: InterPro

estradiol 17-beta-dehydrogenase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 328327Estradiol 17-beta-dehydrogenase 1
PRO_0000251152

Regions

Nucleotide binding10 – 3829NADP By similarity

Sites

Active site1561Proton acceptor By similarity
Binding site661NADP By similarity
Binding site1431Substrate By similarity
Binding site1601NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1WNP0-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: D390680343130598

FASTA32834,889
        10         20         30         40         50         60 
MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA RALACPPGSL 

        70         80         90        100        110        120 
ETLQLDVRDS KSVAAARERV TEGRVDVLVC NAGLGLLGPL EALGEDAVAS VLDVNVVGTV 

       130        140        150        160        170        180 
RVLQAFLPDM KRRGSGRVLV TGSVGGLMGL PFNDVYCASK FALEGLCESL AVLLLPFGVH 

       190        200        210        220        230        240 
LSLIECGPVH TAFMEKVLGS PEEVLDRTDI HTFHRFYQYL AHSKQVFREA AQNPEEVAEV 

       250        260        270        280        290        300 
FLTALRAPKP TLRYFTTERF LPLLRMRLDD PSGSNYVTAM HREVFGDVPA KAEAGAEAGG 

       310        320 
GAGPGAEDEA GPSAVGDPEL GDPPAAPQ 

« Hide

References

[1]"Interspecies comparison of gene structure and computational analysis of gene regulation of 17beta-hydroxysteroid dehydrogenase type 1."
Keller B., Ohnesorg T., Mindnich R., Gloeckner C.J., Breitling R., Scharfe M., Moeller G., Bloecker H., Adamski J.
Mol. Cell. Endocrinol. 248:168-171(2006) [PubMed: 16337734] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

DQ023266 Genomic DNA. Translation: AAZ22356.1.

3D structure databases

SMRQ1WNP0. Positions 1-285, 2-286.
ModBaseSearch...

Genome annotation databases

EnsemblENSPTRG00000009205. Pan troglodytes. [Contig view]

Phylogenomic databases

HOVERGENQ1WNP0.

Family and domain databases

InterProIPR011348. 17beta_DHase.
IPR002198. DHase_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DHase.
IPR016040. NAD(P)-bd.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR19410:SF47. 17beta_DH. 1 hit.
PTHR19410. ADH_short_C2. 1 hit.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFPIRSF000095. 17beta-HSD. 1 hit.
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHB1_PANTR
AccessionPrimary (citable) accession number: Q1WNP0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: January 23, 2007
Last modified: November 25, 2008
This is version 25 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents