Reviewed, UniProtKB/Swiss-Prot Q1WM16 (HXK7_ORYSJ)

Names and origin

Protein names

Recommended name:
    Hexokinase-7
    EC=2.7.1.1
Alternative name(s):
    Hexokinase-6

Gene names

Name:	HXK7
Synonyms:	HXK6
Ordered Locus Names:	Os05g0187100, LOC_Os05g09500
ORF Names:	OJ1097_A12.3

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Fructose and glucose phosphorylating enzyme. Ref.1
Catalytic activity	ATP + D-hexose = ADP + D-hexose 6-phosphate.
Subcellular location	Cytoplasm Probable.
Tissue specificity	Expressed in roots, leaves, flowers, immature seeds and seed coat. Ref.1
Developmental stage	Expressed during flower development until 15 days after flowering. Ref.1
Induction	Down-regulated by glucose or fructose treatment in leaves and immature seeds. Ref.1
Sequence similarities	Belongs to the hexokinase family.
Sequence caution	The sequence AAS86398.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hexokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 463	463	Hexokinase-7		PRO_0000247570
Regions
	Nucleotide binding	73 – 78	6	ATP Potential
	Region	142 – 168	27	Glucose-binding Potential
	Compositional bias	3 – 43	41	Ala-rich
Experimental info
	Sequence conflict	199	1	I → T in AAZ93624. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q1WM16-1 [UniParc]. Last modified July 25, 2006. Version 2. Checksum: C6E3D7D1BB2E19B5	FASTA	463	49,761
	10 20 30 40 50 60 MVAAAVAAAE QVVAALREEC ATPAARLDGV AAAMAGEMAA GLAEEGGSKI KMIVSYVDNL 70 80 90 100 110 120 PNGTEEGLFY ALDLGGTNFR VLRVQLAGKE KRVVKRESRE VSIPPHLMSG NSSELFGFIA 130 140 150 160 170 180 SALAKFVADE GHNAVFNDRQ RELGFTFSFP VRQTSIASGT LIKWTKAFSI DDAVGEDVVA 190 200 210 220 230 240 ELQMAMEKQG LDMRVSALIN DTVGTLAAGS YYDEDIVVGV ILGTGSNAAY LEKANAIPKL 250 260 270 280 290 300 EGELPKSGNM VINTEWGNFS SSCLPITEYD EALDKESLNP GEQIFEKLIS GMYLGEIVRR 310 320 330 340 350 360 VLLKISLQSS IFGNLDQTKL KTRFILRTPD ISVMHHDGTP DLRIVAEKLA DNLKITDTSL 370 380 390 400 410 420 ETRKMVVEIC DIVTRRSARL AAAGIVGILR KIGRGVPGDK RKSVIAIDGG LYEHYTEFRQ 430 440 450 460 CLETTLTELL GEEASKSVAV KLANDGSGLG AALIAAAHSQ YLN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.)." Cho J.-I., Ryoo N., Ko S., Lee S.-K., Lee J., Jung K.-H., Lee Y.-H., Bhoo S.H., Winderickx J., An G., Hahn T.-R., Jeon J.-S. Planta 224:598-611(2006) [PubMed: 16552590] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, NOMENCLATURE. Strain: cv. Jinmi.
[2]	"The hexokinase gene family in rice." Wang Y.D., Cheng W., Wang X.S., Zhou X.J. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Zhonghua 15. Tissue: Flower.
[3]	"A fine physical map of the rice chromosome 5." Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J., Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F., Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y. Mol. Genet. Genomics 274:337-345(2005) [PubMed: 16261349] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ116389 mRNA. Translation: AAZ93624.1. AY884169 mRNA. Translation: AAX68422.1. AC093954 Genomic DNA. Translation: AAS86398.2. Sequence problems.
RefSeq	NP_001054835.1.
UniGene	Os.6114
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4338010.
KEGG	osa:4338010.
Organism-specific databases
Gramene	Q2KNB6.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR019807. Hexokinase_CS. [Graphical view]
PANTHER	PTHR19443. Hexokinase. 1 hit.
Pfam	PF00349. Hexokinase_1. 1 hit. PF03727. Hexokinase_2. 1 hit. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
ProDom	PD001109. Hexokinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00378. HEXOKINASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXK7_ORYSJ

Accession

Primary (citable) accession number: Q1WM16
Secondary accession number(s): Q2KNB6, Q75KY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	October 13, 2009
This is version 23 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)