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Protein

NADP-dependent glyceraldehyde-3-phosphate dehydrogenase

Gene

ALDH11A3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important as a means of generating NADPH for biosynthetic reactions.

Catalytic activityi

D-glyceraldehyde 3-phosphate + NADP+ + H2O = 3-phospho-D-glycerate + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116SubstrateBy similarity1
Sitei169Transition state stabilizerBy similarity1
Binding sitei192NADPBy similarity1
Binding sitei195NADPBy similarity1
Binding sitei230NADPBy similarity1
Active sitei264Proton acceptorPROSITE-ProRule annotation1
Active sitei298NucleophilePROSITE-ProRule annotation1
Binding sitei391NADPBy similarity1
Binding sitei451SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi245 – 249NADBy similarity5

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BioCyciARA:AT2G24270-MONOMER
MetaCyc:AT2G24270-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.9)
Alternative name(s):
Aldehyde dehydrogenase family 11 member A3
Glyceraldehyde-3-phosphate dehydrogenase [NADP(+)]
Non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase
Triosephosphate dehydrogenase
Gene namesi
Name:ALDH11A3
Synonyms:GAPN
Ordered Locus Names:At2g24270
ORF Names:F27D4.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G24270

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002560662 – 496NADP-dependent glyceraldehyde-3-phosphate dehydrogenaseAdd BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei4PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ1WIQ6
PRIDEiQ1WIQ6

PTM databases

iPTMnetiQ1WIQ6

Expressioni

Gene expression databases

ExpressionAtlasiQ1WIQ6 baseline and differential
GenevisibleiQ1WIQ6 AT

Interactioni

Protein-protein interaction databases

BioGridi2314, 4 interactors
IntActiQ1WIQ6, 1 interactor
STRINGi3702.AT2G24270.4

Structurei

3D structure databases

ProteinModelPortaliQ1WIQ6
SMRiQ1WIQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni169 – 170Substrate bindingBy similarity2
Regioni297 – 299Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2450 Eukaryota
COG1012 LUCA
HOGENOMiHOG000271509
InParanoidiQ1WIQ6
KOiK00131
PhylomeDBiQ1WIQ6

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q1WIQ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGTGLFAEI LDGEVYKYYA DGEWKTSSSG KSVAIMNPAT RKTQYKVQAC
60 70 80 90 100
TQEEVNAVME LAKSAQKSWA KTPLWKRAEL LHKAAAILKD NKAPMAESLV
110 120 130 140 150
KEIAKPAKDS VTEVVRSGDL ISYCAEEGVR ILGEGKFLLS DSFPGNDRTK
160 170 180 190 200
YCLTSKIPLG VVLAIPPFNY PVNLAVSKIA PALIAGNSLV LKPPTQGAVS
210 220 230 240 250
CLHMVHCFHL AGFPKGLISC ITGKGSEIGD FLTMHPAVNC ISFTGGDTGI
260 270 280 290 300
SISKKAGMIP LQMELGGKDA CIVLDDADLD LVASNIIKGG FSYSGQRCTA
310 320 330 340 350
VKVVLVMESV ADELVEKVKA KVAKLTVGPP EENSDITAVV SESSANFIEG
360 370 380 390 400
LVMDAKEKGA TFCQEYKREG NLIWPLLLDN VRPDMRIAWE EPFGPVVPVL
410 420 430 440 450
RINSVEEGIN HCNASNFGLQ GCVFTKDINK AILISDAMET GTVQINSAPA
460 470 480 490
RGPDHFPFQG LKDSGIGSQG VTNSINLMTK VKTTVINLPT PSYSMG
Length:496
Mass (Da):53,060
Last modified:October 31, 2006 - v2
Checksum:i9231656A951175D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47V → A in ABB83822 (Ref. 1) Curated1
Sequence conflicti56N → Y in ABB83822 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ268762 mRNA Translation: ABB83822.1
AC005967 Genomic DNA Translation: AAD03388.1
CP002685 Genomic DNA Translation: AEC07553.1
CP002685 Genomic DNA Translation: AEC07554.1
AY037205 mRNA Translation: AAK59790.1
AY136409 mRNA Translation: AAM97075.1
BT004551 mRNA Translation: AAO42797.1
PIRiF84634
RefSeqiNP_001189589.1, NM_001202660.1 [Q1WIQ6-1]
NP_180004.1, NM_127989.4 [Q1WIQ6-1]
UniGeneiAt.22354

Genome annotation databases

EnsemblPlantsiAT2G24270.1; AT2G24270.1; AT2G24270 [Q1WIQ6-1]
AT2G24270.2; AT2G24270.2; AT2G24270
AT2G24270.3; AT2G24270.3; AT2G24270 [Q1WIQ6-1]
GeneIDi816962
GrameneiAT2G24270.1; AT2G24270.1; AT2G24270 [Q1WIQ6-1]
AT2G24270.2; AT2G24270.2; AT2G24270
AT2G24270.3; AT2G24270.3; AT2G24270 [Q1WIQ6-1]
KEGGiath:AT2G24270

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGAPN_ARATH
AccessioniPrimary (citable) accession number: Q1WIQ6
Secondary accession number(s): Q9ZUG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: April 25, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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