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Protein

Cell adhesion molecule 3

Gene

Cadm3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-RNO-418990. Adherens junctions interactions.
R-RNO-420597. Nectin/Necl trans heterodimerization.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule 3
Alternative name(s):
Immunoglobulin superfamily member 4B
Short name:
IgSF4B
Nectin-like protein 1
Short name:
NECL-1
Gene namesi
Name:Cadm3
Synonyms:Igsf4b, Necl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1307035. Cadm3.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity
  • Cell junction By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 328306ExtracellularSequence analysisAdd
BLAST
Transmembranei329 – 34921HelicalSequence analysisAdd
BLAST
Topological domaini350 – 39647CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 396374Cell adhesion molecule 3PRO_0000247989Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 108PROSITE-ProRule annotation
Disulfide bondi150 ↔ 207PROSITE-ProRule annotation
Disulfide bondi252 ↔ 297PROSITE-ProRule annotation
Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence analysis
Modified residuei386 – 3861PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ1WIM3.
PRIDEiQ1WIM3.

PTM databases

iPTMnetiQ1WIM3.
PhosphoSiteiQ1WIM3.

Expressioni

Gene expression databases

ExpressionAtlasiQ1WIM3. baseline and differential.
GenevisibleiQ1WIM3. RN.

Interactioni

Subunit structurei

Homodimer. Can form trans-heterodimers with NECTIN3. Interacts with EPB41L1, DLG3, MPP6 and CASK (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi262276. 1 interaction.
STRINGi10116.ENSRNOP00000004613.

Structurei

3D structure databases

ProteinModelPortaliQ1WIM3.
SMRiQ1WIM3. Positions 25-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 124102Ig-like V-typeAdd
BLAST
Domaini128 – 22699Ig-like C2-type 1Add
BLAST
Domaini231 – 31383Ig-like C2-type 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi322 – 3254Poly-Ser

Domaini

The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.By similarity

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFCE. Eukaryota.
ENOG411017U. LUCA.
GeneTreeiENSGT00770000120518.
HOGENOMiHOG000036057.
HOVERGENiHBG057086.
InParanoidiQ1WIM3.
KOiK06780.
OMAiDIVCSVN.
OrthoDBiEOG7PVWPD.
PhylomeDBiQ1WIM3.
TreeFamiTF326804.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR003585. Neurexin-like.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1WIM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAPSALPLL LLLACSWAPG GANLSQDDSQ PWTSDETVVA GGTVVLKCQV
60 70 80 90 100
KDHEDSSLQW SNPAQQTLYF GEKRALRDNR IQLVSSTPHE LSISISNVAL
110 120 130 140 150
ADEGEYTCSI FTMPVRTAKS LVTVLGIPQK PIITGYKSSL REKETATLNC
160 170 180 190 200
QSSGSKPAAQ LAWRKGDQEL HGDQTRIQED PNGKTFTVSS SVSFQVTRDD
210 220 230 240 250
DGANVVCSVN HESLKGADRS TSQRIEVLYT PTAMIRPEPA HPREGQKLLL
260 270 280 290 300
HCEGRGNPVP QQYVWVKEGS EPPLKMTQES ALIFPFLNKS DSGTYGCTAT
310 320 330 340 350
SNMGSYTAYF TLNVNDPSPV PSSSSTYHAI IGGIVAFIVF LLLILLIFLG
360 370 380 390
HYLIRHKGTY LTHEAKGSDD APDADTAIIN AEGGQSGGDD KKEYFI
Length:396
Mass (Da):42,906
Last modified:May 2, 2006 - v1
Checksum:i6F9C38384CD0E3BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ272743 mRNA. Translation: ABB85362.1.
RefSeqiNP_001040568.1. NM_001047103.1.
UniGeneiRn.138884.

Genome annotation databases

EnsembliENSRNOT00000004613; ENSRNOP00000004613; ENSRNOG00000003365.
GeneIDi360882.
KEGGirno:360882.
UCSCiRGD:1307035. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ272743 mRNA. Translation: ABB85362.1.
RefSeqiNP_001040568.1. NM_001047103.1.
UniGeneiRn.138884.

3D structure databases

ProteinModelPortaliQ1WIM3.
SMRiQ1WIM3. Positions 25-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi262276. 1 interaction.
STRINGi10116.ENSRNOP00000004613.

PTM databases

iPTMnetiQ1WIM3.
PhosphoSiteiQ1WIM3.

Proteomic databases

PaxDbiQ1WIM3.
PRIDEiQ1WIM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004613; ENSRNOP00000004613; ENSRNOG00000003365.
GeneIDi360882.
KEGGirno:360882.
UCSCiRGD:1307035. rat.

Organism-specific databases

CTDi57863.
RGDi1307035. Cadm3.

Phylogenomic databases

eggNOGiENOG410IFCE. Eukaryota.
ENOG411017U. LUCA.
GeneTreeiENSGT00770000120518.
HOGENOMiHOG000036057.
HOVERGENiHBG057086.
InParanoidiQ1WIM3.
KOiK06780.
OMAiDIVCSVN.
OrthoDBiEOG7PVWPD.
PhylomeDBiQ1WIM3.
TreeFamiTF326804.

Enzyme and pathway databases

ReactomeiR-RNO-418990. Adherens junctions interactions.
R-RNO-420597. Nectin/Necl trans heterodimerization.

Miscellaneous databases

PROiQ1WIM3.

Gene expression databases

ExpressionAtlasiQ1WIM3. baseline and differential.
GenevisibleiQ1WIM3. RN.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR003585. Neurexin-like.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nectin-like proteins: candidate cell adhesion molecules to mediate axo-glial interactions."
    Maurel P., Einheber S., Rubin M.B., Galinska J., Thaker P., Murakami Y., Salzer J.L.
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCADM3_RAT
AccessioniPrimary (citable) accession number: Q1WIM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: May 2, 2006
Last modified: July 6, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.