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Protein

Cell adhesion molecule 2

Gene

Cadm2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule 2
Alternative name(s):
Immunoglobulin superfamily member 4D
Short name:
IgSF4D
Nectin-like protein 3
Short name:
NECL-3
Synaptic cell adhesion molecule 2
Short name:
SynCAM 2
Gene namesi
Name:Cadm2
Synonyms:Igsf4d, Necl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305678. Cadm2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 367343ExtracellularSequence analysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence analysisAdd
BLAST
Topological domaini389 – 43547CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: RGD
  • cell-cell adherens junction Source: GO_Central
  • cytoplasm Source: RGD
  • integral component of plasma membrane Source: GO_Central
  • neuronal cell body membrane Source: RGD
  • synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 435411Cell adhesion molecule 2PRO_0000291972Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence analysis
Disulfide bondi44 ↔ 104PROSITE-ProRule annotation
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence analysis
Disulfide bondi146 ↔ 203PROSITE-ProRule annotation
Disulfide bondi248 ↔ 296PROSITE-ProRule annotation
Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence analysis
Modified residuei423 – 4231PhosphoserineCombined sources

Post-translational modificationi

Glycosylation at Asn-51 reduces adhesive binding.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ1WIM2.
PRIDEiQ1WIM2.

PTM databases

iPTMnetiQ1WIM2.
PhosphoSiteiQ1WIM2.
UniCarbKBiQ1WIM2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000030840.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi262128. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ1WIM2.
SMRiQ1WIM2. Positions 27-125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11993Ig-like V-typeAdd
BLAST
Domaini127 – 21993Ig-like C2-type 1Add
BLAST
Domaini227 – 31286Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000036057.
HOVERGENiHBG057086.
InParanoidiQ1WIM2.
KOiK06782.
PhylomeDBiQ1WIM2.
TreeFamiTF326804.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q1WIM2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIWKRSAVLR FYSVCGLLLL GSQGQFPLTQ NVTVVEGGTA ILTCRVDQND
60 70 80 90 100
NTSLQWSNPA QQTLYFDDKK ALRDNRIELV RASWHELSIS VSDVSLSDEG
110 120 130 140 150
QYTCSLFTMP VKTSKAYLTV LGVPEKPQIS GFSSPVMEGD LMQLTCKTSG
160 170 180 190 200
SKPAADIRWF KNDKEIKDVK YLKEEDANRK TFTVSSTLDF RVDRSDDGVA
210 220 230 240 250
VICRVDHESL NATPQVAMQV LEIHYTPSVK IIPSTPFPQE GQALTLTCES
260 270 280 290 300
KGKPLPEPVL WTKDGAELPD PDRMVVSGRE LNILFLNKTD NGTYRCEATN
310 320 330 340 350
TIGQSSAEYV LIVHDVPNTL LPTTIIPSLT TAPVTTTVAI TTSPSTSASS
360 370 380 390 400
SSRRDPNSLA GQNGPDHALI GGIVAVVVFV TLCSIFLLGR YLARHKGTYL
410 420 430
TNEAKGAEDA PDADTAIINA EGSQVNAEEK KEYFI
Length:435
Mass (Da):47,528
Last modified:June 26, 2007 - v2
Checksum:i43EF8BA865C8CE45
GO
Isoform 2 (identifier: Q1WIM2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     315-354: Missing.

Show »
Length:395
Mass (Da):43,502
Checksum:i8642EBBA443DABFB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201L → Q in ABB85363 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei315 – 35440Missing in isoform 2. 1 PublicationVSP_026338Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ272744 mRNA. Translation: ABB85363.1.
AABR03079773 Genomic DNA. No translation available.
AABR03081486 Genomic DNA. No translation available.
AABR03078395 Genomic DNA. No translation available.
AABR03080530 Genomic DNA. No translation available.
AABR03080991 Genomic DNA. No translation available.
AABR03078776 Genomic DNA. No translation available.
RefSeqiNP_001040567.1. NM_001047102.1.
UniGeneiRn.202778.

Genome annotation databases

GeneIDi360687.
KEGGirno:360687.
UCSCiRGD:1305678. rat. [Q1WIM2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ272744 mRNA. Translation: ABB85363.1.
AABR03079773 Genomic DNA. No translation available.
AABR03081486 Genomic DNA. No translation available.
AABR03078395 Genomic DNA. No translation available.
AABR03080530 Genomic DNA. No translation available.
AABR03080991 Genomic DNA. No translation available.
AABR03078776 Genomic DNA. No translation available.
RefSeqiNP_001040567.1. NM_001047102.1.
UniGeneiRn.202778.

3D structure databases

ProteinModelPortaliQ1WIM2.
SMRiQ1WIM2. Positions 27-125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi262128. 1 interaction.

PTM databases

iPTMnetiQ1WIM2.
PhosphoSiteiQ1WIM2.
UniCarbKBiQ1WIM2.

Proteomic databases

PaxDbiQ1WIM2.
PRIDEiQ1WIM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi360687.
KEGGirno:360687.
UCSCiRGD:1305678. rat. [Q1WIM2-1]

Organism-specific databases

CTDi253559.
RGDi1305678. Cadm2.

Phylogenomic databases

HOGENOMiHOG000036057.
HOVERGENiHBG057086.
InParanoidiQ1WIM2.
KOiK06782.
PhylomeDBiQ1WIM2.
TreeFamiTF326804.

Miscellaneous databases

PROiQ1WIM2.

Gene expression databases

BgeeiENSRNOG00000030840.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCADM2_RAT
AccessioniPrimary (citable) accession number: Q1WIM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: September 7, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.