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Protein

GATA-type zinc finger protein 1

Gene

Zglp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for germ cell development. Able to repress GATA transcription factor function.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri197 – 22125GATA-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • oocyte development Source: MGI
  • spermatogenesis Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
GATA-type zinc finger protein 1
Alternative name(s):
GATA-like protein 1
Short name:
GLP-1
Gene namesi
Name:Zglp1
Synonyms:Glp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:3696042. Zglp1.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are viable with no detectable defects in visceral organ development; however, both males and females are completely infertile. In males, the absence of Gpl1 leads to defective sperm development with a marked reduction in mature spermatids observed as early as postnatal week 1. In females, absence of Glp1 leads to a severe block in germ cell development as early as E17.5.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266GATA-type zinc finger protein 1PRO_0000317558Add
BLAST

Proteomic databases

PaxDbiQ1WG82.
PRIDEiQ1WG82.

PTM databases

PhosphoSiteiQ1WG82.

Expressioni

Tissue specificityi

Specifically expressed in adult testis and ovary. Expressed at high levels in the somatic cells of the developing gonads, including Leydig cells in the testes and granulosa cells in the ovaries.1 Publication

Gene expression databases

BgeeiQ1WG82.
CleanExiMM_GLP1.
GenevisibleiQ1WG82. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111157.

Structurei

3D structure databases

ProteinModelPortaliQ1WG82.
SMRiQ1WG82. Positions 188-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 GATA-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri197 – 22125GATA-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00470000042444.
HOGENOMiHOG000074114.
HOVERGENiHBG107952.
InParanoidiQ1WG82.
OMAiPMALGTE.
OrthoDBiEOG78D7P1.
PhylomeDBiQ1WG82.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00320. GATA. 1 hit.
[Graphical view]
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 1 hit.
[Graphical view]
PROSITEiPS50114. GATA_ZN_FINGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1WG82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAAQAGDLT RRQELLAPPC LDTESLRKSR PPALEPGALR CLTPNIRSLW
60 70 80 90 100
PTCQDSVSTA LPFLQEKEKG LPGSPSPATQ VLGSCWELMV IGMSDHLSMA
110 120 130 140 150
RNPRGTQCPN LEISSATSPA SLQRRPRKQL NPRMGIEKVD PRFKGVTLEF
160 170 180 190 200
QIQPDSSLQI VPTYSLPGRS CSQKLPASPS KALASPGSSE ALGPRRCASC
210 220 230 240 250
RTQRTPLWRD AEDGTPLCNA CGIRYKKYGT RCSSCWLVPR KSIQPKRLCG
260
RCGMSQDPHL SPTQEL
Length:266
Mass (Da):29,107
Last modified:May 2, 2006 - v1
Checksum:i40E266B6C889D587
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ286956 mRNA. Translation: ABB89941.1.
CCDSiCCDS40549.1.
RefSeqiNP_001096638.1. NM_001103168.1.
UniGeneiMm.483362.

Genome annotation databases

EnsembliENSMUST00000115494; ENSMUSP00000111157; ENSMUSG00000079681.
GeneIDi100009600.
KEGGimmu:100009600.
UCSCiuc009veu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ286956 mRNA. Translation: ABB89941.1.
CCDSiCCDS40549.1.
RefSeqiNP_001096638.1. NM_001103168.1.
UniGeneiMm.483362.

3D structure databases

ProteinModelPortaliQ1WG82.
SMRiQ1WG82. Positions 188-229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111157.

PTM databases

PhosphoSiteiQ1WG82.

Proteomic databases

PaxDbiQ1WG82.
PRIDEiQ1WG82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115494; ENSMUSP00000111157; ENSMUSG00000079681.
GeneIDi100009600.
KEGGimmu:100009600.
UCSCiuc009veu.1. mouse.

Organism-specific databases

CTDi100125288.
MGIiMGI:3696042. Zglp1.

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00470000042444.
HOGENOMiHOG000074114.
HOVERGENiHBG107952.
InParanoidiQ1WG82.
OMAiPMALGTE.
OrthoDBiEOG78D7P1.
PhylomeDBiQ1WG82.

Miscellaneous databases

ChiTaRSiZglp1. mouse.
NextBioi440443.
PROiQ1WG82.
SOURCEiSearch...

Gene expression databases

BgeeiQ1WG82.
CleanExiMM_GLP1.
GenevisibleiQ1WG82. MM.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00320. GATA. 1 hit.
[Graphical view]
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 1 hit.
[Graphical view]
PROSITEiPS50114. GATA_ZN_FINGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "GLP-1: a novel zinc finger protein required in somatic cells of the gonad for germ cell development."
    Li S., Lu M.M., Zhou D., Hammes S.R., Morrisey E.E.
    Dev. Biol. 301:106-116(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    Strain: C57BL/6J.

Entry informationi

Entry nameiZGLP1_MOUSE
AccessioniPrimary (citable) accession number: Q1WG82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 2, 2006
Last modified: May 11, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.