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Protein

GATA-type zinc finger protein 1

Gene

Zglp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for germ cell development. Able to repress GATA transcription factor function.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri197 – 221GATA-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • oocyte development Source: MGI
  • spermatogenesis Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
GATA-type zinc finger protein 1
Alternative name(s):
GATA-like protein 1
Short name:
GLP-1
Gene namesi
Name:Zglp1
Synonyms:Glp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:3696042 Zglp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are viable with no detectable defects in visceral organ development; however, both males and females are completely infertile. In males, the absence of Gpl1 leads to defective sperm development with a marked reduction in mature spermatids observed as early as postnatal week 1. In females, absence of Glp1 leads to a severe block in germ cell development as early as E17.5.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175581 – 266GATA-type zinc finger protein 1Add BLAST266

Proteomic databases

PaxDbiQ1WG82
PRIDEiQ1WG82

PTM databases

PhosphoSitePlusiQ1WG82

Expressioni

Tissue specificityi

Specifically expressed in adult testis and ovary. Expressed at high levels in the somatic cells of the developing gonads, including Leydig cells in the testes and granulosa cells in the ovaries.1 Publication

Gene expression databases

BgeeiENSMUSG00000079681
CleanExiMM_GLP1
GenevisibleiQ1WG82 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111157

Structurei

3D structure databases

ProteinModelPortaliQ1WG82
SMRiQ1WG82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri197 – 221GATA-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1601 Eukaryota
COG5641 LUCA
GeneTreeiENSGT00470000042444
HOGENOMiHOG000074114
HOVERGENiHBG107952
InParanoidiQ1WG82
KOiK21630
OrthoDBiEOG091G0O9L
PhylomeDBiQ1WG82

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR000679 Znf_GATA
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00320 GATA, 1 hit
PRINTSiPR00619 GATAZNFINGER
SMARTiView protein in SMART
SM00401 ZnF_GATA, 1 hit
PROSITEiView protein in PROSITE
PS50114 GATA_ZN_FINGER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q1WG82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAAQAGDLT RRQELLAPPC LDTESLRKSR PPALEPGALR CLTPNIRSLW
60 70 80 90 100
PTCQDSVSTA LPFLQEKEKG LPGSPSPATQ VLGSCWELMV IGMSDHLSMA
110 120 130 140 150
RNPRGTQCPN LEISSATSPA SLQRRPRKQL NPRMGIEKVD PRFKGVTLEF
160 170 180 190 200
QIQPDSSLQI VPTYSLPGRS CSQKLPASPS KALASPGSSE ALGPRRCASC
210 220 230 240 250
RTQRTPLWRD AEDGTPLCNA CGIRYKKYGT RCSSCWLVPR KSIQPKRLCG
260
RCGMSQDPHL SPTQEL
Length:266
Mass (Da):29,107
Last modified:May 2, 2006 - v1
Checksum:i40E266B6C889D587
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ286956 mRNA Translation: ABB89941.1
CCDSiCCDS40549.1
RefSeqiNP_001096638.1, NM_001103168.1
UniGeneiMm.483362

Genome annotation databases

EnsembliENSMUST00000115494; ENSMUSP00000111157; ENSMUSG00000079681
GeneIDi100009600
KEGGimmu:100009600
UCSCiuc009veu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiZGLP1_MOUSE
AccessioniPrimary (citable) accession number: Q1WG82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 2, 2006
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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