Q1W675 (HMDH_PIG) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 49.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase Short name=HMG-CoA reductase EC=1.1.1.34 | ||||
| Gene names |
| ||||
| Organism | Sus scrofa (Pig) [Complete proteome] | ||||
| Taxonomic identifier | 9823 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus |
Protein attributes
| Sequence length | 885 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis. |
| Catalytic activity | (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Peroxisome membrane; Multi-pass membrane protein By similarity. |
| Sequence similarities | Belongs to the HMG-CoA reductase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 885 | 885 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | PRO_0000258020 | |||||
Regions | |||||||||
| Transmembrane | 10 – 39 | 30 | Helical; Potential | ||||||
| Transmembrane | 57 – 78 | 22 | Helical; Potential | ||||||
| Transmembrane | 90 – 114 | 25 | Helical; Potential | ||||||
| Transmembrane | 124 – 149 | 26 | Helical; Potential | ||||||
| Transmembrane | 160 – 187 | 28 | Helical; Potential | ||||||
| Transmembrane | 192 – 220 | 29 | Helical; Potential | ||||||
| Transmembrane | 315 – 339 | 25 | Helical; Potential | ||||||
| Region | 340 – 448 | 109 | Linker | ||||||
| Region | 449 – 885 | 437 | Catalytic | ||||||
Sites | |||||||||
| Active site | 558 | 1 | Charge relay system By similarity | ||||||
| Active site | 688 | 1 | Charge relay system By similarity | ||||||
| Active site | 764 | 1 | Charge relay system By similarity | ||||||
| Active site | 863 | 1 | Proton donor By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 869 | 1 | Phosphoserine; by AMPK By similarity | ||||||
| Glycosylation | 281 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 296 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 419 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 517 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 867 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Molecular cloning, expression analysis and chromosomal location of the porcine 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) gene." Wang X.F., Wang A.G., Fu J.L., Li Z.J., Kong L.J., Liu G.F., Fang W.N., Lu J.H. Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | DQ432054 mRNA. Translation: ABD96089.1. DQ531631 Genomic DNA. Translation: ABF83891.1. |
| RefSeq | NP_001116460.1. NM_001122988.1. |
| UniGene | Ssc.16088. |
3D structure databases | |
| ProteinModelPortal | Q1W675. |
| SMR | Q1W675. Positions 440-860. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q1W675. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 100144446. |
| KEGG | ssc:100144446. |
Organism-specific databases | |
| CTD | 3156. |
Phylogenomic databases | |
| HOVERGEN | HBG000453. |
| OrthoDB | EOG47WNN1. |
Family and domain databases | |
| InterPro | IPR002202. HMG_CoA_Rdtase. IPR023074. HMG_CoA_Rdtase_cat. IPR023076. HMG_CoA_Rdtase_CS. IPR004554. HMG_CoA_Rdtase_eu_arc. IPR004816. HMG_CoA_Rdtase_metazoan. IPR023282. HMG_CoA_Rdtase_N. IPR009023. HMG_CoA_Rdtase_NAD(P)-bd. IPR009029. HMG_CoA_Rdtase_sub-bd. IPR000731. SSD. [Graphical view] |
| Gene3D | G3DSA:3.30.70.420. G3DSA:3.30.70.420. 1 hit. G3DSA:3.90.770.10. HMG-CoA_red. 2 hits. G3DSA:1.10.3270.10. HMG_CoA_Rdtase_N. 1 hit. |
| KO | K00021. |
| PANTHER | PTHR10572. HMG-CoA_red. 1 hit. |
| Pfam | PF00368. HMG-CoA_red. 1 hit. [Graphical view] |
| PRINTS | PR00071. HMGCOARDTASE. |
| SUPFAM | SSF55035. HMG_CoA_NAD_bind. 1 hit. SSF56542. HMG_CoA_sub_bind. 1 hit. |
| TIGRFAMs | TIGR00920. 2A060605. 1 hit. TIGR00533. HMG_CoA_R_NADP. 1 hit. |
| PROSITE | PS00066. HMG_COA_REDUCTASE_1. 1 hit. PS00318. HMG_COA_REDUCTASE_2. 1 hit. PS01192. HMG_COA_REDUCTASE_3. 1 hit. PS50065. HMG_COA_REDUCTASE_4. 1 hit. PS50156. SSD. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HMDH_PIG | ||||||||
| Accession | Primary (citable) accession number: Q1W675 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with