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Q1W675 (HMDH_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Short name=HMG-CoA reductase
EC=1.1.1.34
Gene names
Name:HMGCR
Synonyms:HMGR
OrganismSus scrofa (Pig) [Complete proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length885 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis.

Catalytic activity

(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.

Pathway

Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.

Subunit structure

Homodimer By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Peroxisome membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the HMG-CoA reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8858853-hydroxy-3-methylglutaryl-coenzyme A reductase
PRO_0000258020

Regions

Transmembrane10 – 3930Helical; Potential
Transmembrane57 – 7822Helical; Potential
Transmembrane90 – 11425Helical; Potential
Transmembrane124 – 14926Helical; Potential
Transmembrane160 – 18728Helical; Potential
Transmembrane192 – 22029Helical; Potential
Transmembrane315 – 33925Helical; Potential
Region340 – 448109Linker
Region449 – 885437Catalytic

Sites

Active site5581Charge relay system By similarity
Active site6881Charge relay system By similarity
Active site7641Charge relay system By similarity
Active site8631Proton donor By similarity

Amino acid modifications

Modified residue8691Phosphoserine; by AMPK By similarity
Glycosylation2811N-linked (GlcNAc...) Potential
Glycosylation2961N-linked (GlcNAc...) Potential
Glycosylation4191N-linked (GlcNAc...) Potential
Glycosylation5171N-linked (GlcNAc...) Potential
Glycosylation8671N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q1W675 [UniParc].

Last modified May 2, 2006. Version 1.
Checksum: 046E93BF1155FAD2

FASTA88597,151
        10         20         30         40         50         60 
MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN DKICGWNYEC PKFEEDVLSS 

        70         80         90        100        110        120 
DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI FSSFVFSTVV IHFLDKELTG 

       130        140        150        160        170        180 
LNEALPFFLL LIDLSRASAL AKFALSSNSQ DEVRENIARG MAILGPTFTL DALVECLVIG 

       190        200        210        220        230        240 
VGTMSGVRQL EIMCCFGCMS VLATYFVFMT FFPACVSLVL ELSRESREGR PIWQLSHFAR 

       250        260        270        280        290        300 
VLEGEENKPN PVTQRVKIIM SLGLVLVHAH SRWIADPSPQ NSTADNSKVS LGLDENVSKR 

       310        320        330        340        350        360 
IEPSVSLWQF YLSKMISMDI EQVITLTLAL LLAVKYIFFE QAETESTLSL KNPITSPVVT 

       370        380        390        400        410        420 
QKKVTDDCCR REPTLVRNDQ KFHTVEEEAR INRERKVEVI KPLVAETDTS SRPTFVVGNS 

       430        440        450        460        470        480 
TLDSSLELEM QEPEIQIPSE PRPNEECLQI LGNAEKGAKF LSDAEIIQLV NAKHIPAYKL 

       490        500        510        520        530        540 
ETLMETHERG VSIRRQLLSK KLPEPSSLQY LPYRDYNYSL VMGACCENVI GYMPIPVGVA 

       550        560        570        580        590        600 
GPLCLDGKEF QVPMATTEGC LVASTNRGCR AIGLGGGASS RILADGMTPV VRFPRACDSA 

       610        620        630        640        650        660 
EVKAWLETPE GFAVIKEAFD STSRFARLQK LQMSVAGRNL YIRFQSRSGD AMGMNMISKG 

       670        680        690        700        710        720 
TEKALSKLHE YFPEMQILAV SGNYCTDKKP AAVNWIEGRG KSVVCEAVIP AKVVREVLKT 

       730        740        750        760        770        780 
TTEAMVEVNI NKNLVGSAMA GSIGGYNAHA ANIVTAIYIA CGQDAAQNVG SSNCITLMEA 

       790        800        810        820        830        840 
SGPTNEDLYI SCTMPSIEIG TVGGGTSLLP QQACLQMLGV QGACKDNPGE NARQLARIVC 

       850        860        870        880 
GTVMAGELSL MAALAAGHLV RSHMIHNRSK INLQDLQGTC TKKAA

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References

[1]"Molecular cloning, expression analysis and chromosomal location of the porcine 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) gene."
Wang X.F., Wang A.G., Fu J.L., Li Z.J., Kong L.J., Liu G.F., Fang W.N., Lu J.H.
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DQ432054 mRNA. Translation: ABD96089.1.
DQ531631 Genomic DNA. Translation: ABF83891.1.
RefSeqNP_001116460.1. NM_001122988.1.
UniGeneSsc.16088.

3D structure databases

ProteinModelPortalQ1W675.
SMRQ1W675. Positions 440-860.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1W675.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100144446.
KEGGssc:100144446.

Organism-specific databases

CTD3156.

Phylogenomic databases

HOVERGENHBG000453.
OrthoDBEOG47WNN1.

Family and domain databases

InterProIPR002202. HMG_CoA_Rdtase.
IPR023074. HMG_CoA_Rdtase_cat.
IPR023076. HMG_CoA_Rdtase_CS.
IPR004554. HMG_CoA_Rdtase_eu_arc.
IPR004816. HMG_CoA_Rdtase_metazoan.
IPR023282. HMG_CoA_Rdtase_N.
IPR009023. HMG_CoA_Rdtase_NAD(P)-bd.
IPR009029. HMG_CoA_Rdtase_sub-bd.
IPR000731. SSD.
[Graphical view]
Gene3DG3DSA:3.30.70.420. G3DSA:3.30.70.420. 1 hit.
G3DSA:3.90.770.10. HMG-CoA_red. 2 hits.
G3DSA:1.10.3270.10. HMG_CoA_Rdtase_N. 1 hit.
KOK00021.
PANTHERPTHR10572. HMG-CoA_red. 1 hit.
PfamPF00368. HMG-CoA_red. 1 hit.
[Graphical view]
PRINTSPR00071. HMGCOARDTASE.
SUPFAMSSF55035. HMG_CoA_NAD_bind. 1 hit.
SSF56542. HMG_CoA_sub_bind. 1 hit.
TIGRFAMsTIGR00920. 2A060605. 1 hit.
TIGR00533. HMG_CoA_R_NADP. 1 hit.
PROSITEPS00066. HMG_COA_REDUCTASE_1. 1 hit.
PS00318. HMG_COA_REDUCTASE_2. 1 hit.
PS01192. HMG_COA_REDUCTASE_3. 1 hit.
PS50065. HMG_COA_REDUCTASE_4. 1 hit.
PS50156. SSD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHMDH_PIG
AccessionPrimary (citable) accession number: Q1W675
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 2, 2006
Last modified: December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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