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Q1W377

- PMM_SOLLC

UniProt

Q1W377 - PMM_SOLLC

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Protein

Phosphomannomutase

Gene
N/A
Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in ascorbic acid biosynthesis and in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei13 – 131NucleophileBy similarity
Active sitei15 – 151Proton donor/acceptorSequence Analysis
Binding sitei22 – 221SubstrateBy similarity
Binding sitei124 – 1241SubstrateBy similarity
Binding sitei135 – 1351SubstrateBy similarity
Binding sitei142 – 1421SubstrateBy similarity
Binding sitei180 – 1801SubstrateBy similarity
Binding sitei182 – 1821SubstrateBy similarity

GO - Molecular functioni

  1. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. mannose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Alternative name(s):
LePMM
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
ProteomesiUP000004994: Unplaced

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252PhosphomannomutasePRO_0000326494Add
BLAST

Proteomic databases

PRIDEiQ1W377.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ1W377.
SMRiQ1W377. Positions 9-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

KOiK17497.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1W377-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAARKAGLIA LFDVDGTLTA PRKESTPQML KFMQELRKVV TVGVVGGSDL
60 70 80 90 100
VKISEQLGNT VTNDYDYVFS ENGLVAHKDG KLIGKQSLKS HLGDEKLKEF
110 120 130 140 150
INFTLHYIAD LDIPIKRGTF IEFRSGMLNV SPIGRNCSQE ERDEFEKYDK
160 170 180 190 200
VQKIRETMVS VLREKFAHFN LTFSIGGQIS FDVFPQGWDK TYCLRYLEEF
210 220 230 240 250
NEIHFFGDKT YKGGNDHEIY ESERTVGHTV TSPEETLKQC SVLFLGKDNG

SS
Length:252
Mass (Da):28,556
Last modified:May 2, 2006 - v1
Checksum:iAE3E701AC82DCC82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ442993 mRNA. Translation: ABD97872.1.
RefSeqiNP_001233801.1. NM_001246872.1.
UniGeneiLes.5106.

Genome annotation databases

GeneIDi778245.
KEGGisly:778245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ442993 mRNA. Translation: ABD97872.1 .
RefSeqi NP_001233801.1. NM_001246872.1.
UniGenei Les.5106.

3D structure databases

ProteinModelPortali Q1W377.
SMRi Q1W377. Positions 9-244.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q1W377.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 778245.
KEGGi sly:778245.

Phylogenomic databases

KOi K17497.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00424 .

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view ]
PANTHERi PTHR10466. PTHR10466. 1 hit.
Pfami PF03332. PMM. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular and functional analysis of phosphomannomutase (PMM) from higher plants and genetic evidence for the involvement of PMM in ascorbic acid biosynthesis in Arabidopsis and Nicotiana benthamiana."
    Qian W., Yu C., Qin H., Liu X., Zhang A., Johansen I.E., Wang D.
    Plant J. 49:399-413(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPMM_SOLLC
AccessioniPrimary (citable) accession number: Q1W377
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3