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Protein

Phosphomannomutase

Gene
N/A
Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in ascorbic acid biosynthesis and in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphomannomutase (101264724), Phosphomannomutase (101267428), Phosphomannomutase (778245), Phosphomannomutase, Phosphomannomutase
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei13NucleophileBy similarity1
Active sitei15Proton donor/acceptorSequence analysis1
Binding sitei22SubstrateBy similarity1
Binding sitei124SubstrateBy similarity1
Binding sitei135SubstrateBy similarity1
Binding sitei142SubstrateBy similarity1
Binding sitei180SubstrateBy similarity1
Binding sitei182SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Alternative name(s):
LePMM
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003264941 – 252PhosphomannomutaseAdd BLAST252

Proteomic databases

PaxDbiQ1W377.
PRIDEiQ1W377.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi4081.Solyc08g008670.2.1.

Structurei

3D structure databases

ProteinModelPortaliQ1W377.
SMRiQ1W377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

eggNOGiKOG3189. Eukaryota.
COG0561. LUCA.

Family and domain databases

CDDicd02585. HAD_PMM. 1 hit.
Gene3Di3.40.50.1000. 2 hits.
InterProiView protein in InterPro
IPR036412. HAD-like_sf.
IPR006379. HAD-SF_hydro_IIB.
IPR023214. HAD_sf.
IPR005002. PMM.
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiView protein in Pfam
PF03332. PMM. 1 hit.
SFLDiSFLDG01143. C2.B.3:_Phosphomannomutase_Lik. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1W377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARKAGLIA LFDVDGTLTA PRKESTPQML KFMQELRKVV TVGVVGGSDL
60 70 80 90 100
VKISEQLGNT VTNDYDYVFS ENGLVAHKDG KLIGKQSLKS HLGDEKLKEF
110 120 130 140 150
INFTLHYIAD LDIPIKRGTF IEFRSGMLNV SPIGRNCSQE ERDEFEKYDK
160 170 180 190 200
VQKIRETMVS VLREKFAHFN LTFSIGGQIS FDVFPQGWDK TYCLRYLEEF
210 220 230 240 250
NEIHFFGDKT YKGGNDHEIY ESERTVGHTV TSPEETLKQC SVLFLGKDNG

SS
Length:252
Mass (Da):28,556
Last modified:May 2, 2006 - v1
Checksum:iAE3E701AC82DCC82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ442993 mRNA. Translation: ABD97872.1.
UniGeneiLes.5106.

Similar proteinsi

Entry informationi

Entry nameiPMM_SOLLC
AccessioniPrimary (citable) accession number: Q1W377
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: October 25, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families