Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphomannomutase

Gene
N/A
Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in ascorbic acid biosynthesis and in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei13 – 131NucleophileBy similarity
Active sitei15 – 151Proton donor/acceptorSequence Analysis
Binding sitei22 – 221SubstrateBy similarity
Binding sitei124 – 1241SubstrateBy similarity
Binding sitei135 – 1351SubstrateBy similarity
Binding sitei142 – 1421SubstrateBy similarity
Binding sitei180 – 1801SubstrateBy similarity
Binding sitei182 – 1821SubstrateBy similarity

GO - Molecular functioni

  1. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. mannose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Alternative name(s):
GmPMM
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
ProteomesiUP000008827 Componenti: Chromosome 18

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247PhosphomannomutasePRO_0000326495Add
BLAST

Proteomic databases

PRIDEiQ1W376.

Expressioni

Gene expression databases

GenevestigatoriQ1W376.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ1W376.
SMRiQ1W376. Positions 6-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

InParanoidiQ1W376.
KOiK17497.
OMAiQEERLEF.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1W376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARRPGLIA LFDVDGTLTA PRKVVTPEML TFMQELRKVV TVGVVGGSDL
60 70 80 90 100
IKISEQLGST VTNDYDYVFS ENGLVAHKEG KLIGTQSLKS FLGEEKLKEF
110 120 130 140 150
INFTLHYIAD LDIPIKRGTF IEFRSGMLNV SPIGRNCSQE ERDEFEKYDK
160 170 180 190 200
VHNIRPKMVS VLREKFAHLN LTFSIGGQIS FDVFPQGWDK TYCLRYLDGF
210 220 230 240
NEIHFFGDKT YKGGNDHEIY ESERTVGHTV TSPDDTVKQC KSLFLEN
Length:247
Mass (Da):28,019
Last modified:May 2, 2006 - v1
Checksum:i7FF516DFA51220A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ442994 mRNA. Translation: ABD97873.1.
RefSeqiNP_001237668.1. NM_001250739.1.
XP_006601866.1. XM_006601803.1.
UniGeneiGma.3992.

Genome annotation databases

EnsemblPlantsiGLYMA18G46390.1; GLYMA18G46390.1; GLYMA18G46390.
GeneIDi732605.
KEGGigmx:732605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ442994 mRNA. Translation: ABD97873.1.
RefSeqiNP_001237668.1. NM_001250739.1.
XP_006601866.1. XM_006601803.1.
UniGeneiGma.3992.

3D structure databases

ProteinModelPortaliQ1W376.
SMRiQ1W376. Positions 6-244.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ1W376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiGLYMA18G46390.1; GLYMA18G46390.1; GLYMA18G46390.
GeneIDi732605.
KEGGigmx:732605.

Phylogenomic databases

InParanoidiQ1W376.
KOiK17497.
OMAiQEERLEF.

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.

Gene expression databases

GenevestigatoriQ1W376.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular and functional analysis of phosphomannomutase (PMM) from higher plants and genetic evidence for the involvement of PMM in ascorbic acid biosynthesis in Arabidopsis and Nicotiana benthamiana."
    Qian W., Yu C., Qin H., Liu X., Zhang A., Johansen I.E., Wang D.
    Plant J. 49:399-413(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPMM_SOYBN
AccessioniPrimary (citable) accession number: Q1W376
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: January 7, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.