Q1W376 (PMM_SOYBN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Phosphomannomutase EC=5.4.2.8 Alternative name(s): GmPMM
Organism	Glycine max (Soybean) (Glycine hispida) [Reference proteome]
Taxonomic identifier	3847 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Fabales › Fabaceae › Papilionoideae › Phaseoleae › Glycine

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in ascorbic acid biosynthesis and in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.
Catalytic activity	Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the eukaryotic PMM family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	GDP-mannose biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway mannose biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphomannomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 247	247	Phosphomannomutase		PRO_0000326495
Sites
	Active site	13	1	Nucleophile By similarity
	Active site	15	1	By similarity
	Active site	48	1	By similarity
	Active site	190	1	By similarity
	Binding site	22	1	Substrate By similarity
	Binding site	124	1	Substrate By similarity
	Binding site	135	1	Substrate By similarity
	Binding site	142	1	Substrate By similarity
	Binding site	180	1	Substrate By similarity
	Binding site	182	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1W376 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 7FF516DFA51220A1	FASTA	247	28,019
	10 20 30 40 50 60 MAARRPGLIA LFDVDGTLTA PRKVVTPEML TFMQELRKVV TVGVVGGSDL IKISEQLGST 70 80 90 100 110 120 VTNDYDYVFS ENGLVAHKEG KLIGTQSLKS FLGEEKLKEF INFTLHYIAD LDIPIKRGTF 130 140 150 160 170 180 IEFRSGMLNV SPIGRNCSQE ERDEFEKYDK VHNIRPKMVS VLREKFAHLN LTFSIGGQIS 190 200 210 220 230 240 FDVFPQGWDK TYCLRYLDGF NEIHFFGDKT YKGGNDHEIY ESERTVGHTV TSPDDTVKQC KSLFLEN

References

[1]

"Molecular and functional analysis of phosphomannomutase (PMM) from higher plants and genetic evidence for the involvement of PMM in ascorbic acid biosynthesis in Arabidopsis and Nicotiana benthamiana." Qian W., Yu C., Qin H., Liu X., Zhang A., Johansen I.E., Wang D. Plant J. 49:399-413(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ442994 mRNA. Translation: ABD97873.1.
RefSeq	NP_001237668.1. NM_001250739.1.
UniGene	Gma.3992.
3D structure databases
ProteinModelPortal	Q1W376.
SMR	Q1W376. Positions 6-244.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	GLYMA18G46390.1; GLYMA18G46390.1; GLYMA18G46390.
GeneID	732605.
KEGG	gmx:732605.
Phylogenomic databases
KO	K01840.
Enzyme and pathway databases
UniPathway	UPA00126; UER00424.
Gene expression databases
Genevestigator	Q1W376.
Family and domain databases
Gene3D	3.40.50.1000. 2 hits.
InterPro	IPR023214. HAD-like_dom. IPR006379. HAD-SF_hydro_IIB. IPR005002. PMM. [Graphical view]
PANTHER	PTHR10466. PTHR10466. 1 hit.
Pfam	PF03332. PMM. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01484. HAD-SF-IIB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PMM_SOYBN

Accession

Primary (citable) accession number: Q1W376

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 2, 2006
Last modified:	March 6, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program