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Q1W375

- PMM_TOBAC

UniProt

Q1W375 - PMM_TOBAC

Protein

Phosphomannomutase

Gene
N/A
Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (02 May 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in ascorbic acid biosynthesis and in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

    Catalytic activityi

    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei13 – 131NucleophileBy similarity
    Active sitei15 – 151Proton donor/acceptorSequence Analysis
    Binding sitei22 – 221SubstrateBy similarity
    Binding sitei124 – 1241SubstrateBy similarity
    Binding sitei135 – 1351SubstrateBy similarity
    Binding sitei142 – 1421SubstrateBy similarity
    Binding sitei180 – 1801SubstrateBy similarity
    Binding sitei182 – 1821SubstrateBy similarity

    GO - Molecular functioni

    1. phosphomannomutase activity Source: UniProtKB-EC

    GO - Biological processi

    1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
    2. mannose biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    UniPathwayiUPA00126; UER00424.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphomannomutase (EC:5.4.2.8)
    Alternative name(s):
    NtPMM
    OrganismiNicotiana tabacum (Common tobacco)
    Taxonomic identifieri4097 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 252252PhosphomannomutasePRO_0000326496Add
    BLAST

    Proteomic databases

    PRIDEiQ1W375.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ1W375.
    SMRiQ1W375. Positions 10-243.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic PMM family.Curated

    Family and domain databases

    Gene3Di3.40.50.1000. 2 hits.
    InterProiIPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR005002. PMM.
    [Graphical view]
    PANTHERiPTHR10466. PTHR10466. 1 hit.
    PfamiPF03332. PMM. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1W375-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAARKPGLIA LFDVDGTLTA PRKEVTPEML KFMKELRKVV TVGVVGGSDL    50
    VKISEQLGKT VTTDYDYCFS ENGLVAHKDG KLIGTQSLKS FLGDEKLKEF 100
    INFTLHYIAD LDIPIKRGTF IEFRSGMLNV SPIGRDCSQE ERDEFEKYDK 150
    VHKIRQTMVS VLREKFAHLN LTFSIGGQIS FDVFPQGWDK TYCLRYLEEF 200
    NEIHFFGDKT YKGGNDHEIY ESERTVGHTV TSPEDTVKQC SEQFLGKDNG 250
    SS 252
    Length:252
    Mass (Da):28,575
    Last modified:May 2, 2006 - v1
    Checksum:iE9820AF015B0099A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ442995 mRNA. Translation: ABD97874.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ442995 mRNA. Translation: ABD97874.1 .

    3D structure databases

    ProteinModelPortali Q1W375.
    SMRi Q1W375. Positions 10-243.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q1W375.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00424 .

    Family and domain databases

    Gene3Di 3.40.50.1000. 2 hits.
    InterProi IPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR005002. PMM.
    [Graphical view ]
    PANTHERi PTHR10466. PTHR10466. 1 hit.
    Pfami PF03332. PMM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and functional analysis of phosphomannomutase (PMM) from higher plants and genetic evidence for the involvement of PMM in ascorbic acid biosynthesis in Arabidopsis and Nicotiana benthamiana."
      Qian W., Yu C., Qin H., Liu X., Zhang A., Johansen I.E., Wang D.
      Plant J. 49:399-413(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPMM_TOBAC
    AccessioniPrimary (citable) accession number: Q1W375
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Caution

    PubMed:17217471 indicates this sequence as being of Nicotiana benthamiana origin.Curated

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3