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Protein

Phosphomannomutase

Gene
N/A
Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in ascorbic acid biosynthesis and in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphomannomutase, Phosphomannomutase, Phosphomannomutase, Phosphomannomutase, Phosphomannomutase (PMM-A1), Phosphomannomutase, Phosphomannomutase (PMM-B2), Phosphomannomutase, Phosphomannomutase (PMM-B1), Phosphomannomutase (PMM-D1), Phosphomannomutase, Phosphomannomutase, Phosphomannomutase, Phosphomannomutase (PMM-D2), Phosphomannomutase
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei15NucleophileBy similarity1
Active sitei17Proton donor/acceptorSequence analysis1
Binding sitei24SubstrateBy similarity1
Binding sitei126SubstrateBy similarity1
Binding sitei137SubstrateBy similarity1
Binding sitei144SubstrateBy similarity1
Binding sitei182SubstrateBy similarity1
Binding sitei184SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Alternative name(s):
TaPMM
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeTriticinaeTriticum
Proteomesi
  • UP000019116 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003264971 – 249PhosphomannomutaseAdd BLAST249

Proteomic databases

PRIDEiQ1W374.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ1W374.
SMRiQ1W374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiView protein in InterPro
IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiView protein in Pfam
PF03332. PMM. 1 hit.
SFLDiSFLDG01143. C2.B.3:_Phosphomannomutase_Lik. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1W374-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAARKDAGV LALFDVDGTL TAPRKEVTPE MLEFMKRLRE NVTVGVVGGS
60 70 80 90 100
DLVKISEQLG KSVITDYDYV FSENGLVAHK DGKLIGTQSL KTYLGDDQLK
110 120 130 140 150
EFINFTLHYI ADLDIPIKRG TFIEFRSGMI NVSPIGRNCS QEERDDFEKY
160 170 180 190 200
DKVHNVRPKM VSVLREKFAH LNLTFSIGGQ ISFDVFPQGW DKTYCLRYLE
210 220 230 240
EFKEIHFFGD KTYKGGNDHE IFESDRTVGH TVTSPNDTVQ QCKSIFLSE
Length:249
Mass (Da):28,252
Last modified:May 2, 2006 - v1
Checksum:iAB85F0AB97DCD566
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ442996 mRNA. Translation: ABD97875.1.
UniGeneiTa.3539.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ442996 mRNA. Translation: ABD97875.1.
UniGeneiTa.3539.

3D structure databases

ProteinModelPortaliQ1W374.
SMRiQ1W374.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ1W374.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiView protein in InterPro
IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiView protein in Pfam
PF03332. PMM. 1 hit.
SFLDiSFLDG01143. C2.B.3:_Phosphomannomutase_Lik. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPMM_WHEAT
AccessioniPrimary (citable) accession number: Q1W374
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: May 10, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.