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Protein

Embryonic stem cell-related gene protein

Gene

ESRG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Embryonic stem cell-related gene protein
Short name:
hES cell-related gene protein
Gene namesi
Name:ESRG
Synonyms:HESRG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:39079. ESRG.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Embryonic stem cell-related gene proteinPRO_0000323559Add
BLAST

Proteomic databases

PRIDEiQ1W209.

Expressioni

Tissue specificityi

Expressed only in fetal ovary and in undifferentiated ES cells.2 Publications

Inductioni

Down-regulated during differentiation of ES cells.1 Publication

Family & Domainsi

Phylogenomic databases

InParanoidiQ1W209.

Sequencei

Sequence statusi: Complete.

Q1W209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLFSDSARL HPGEINSLVA HTKPVWWSLH TDAHEIWCRD SDRGTSLGRS
60 70 80 90 100
IPCPPALCSV RKIHLRPQVL RPTSPRNISP ISNPVSGLFL LCSPTSLTIP
110 120 130 140 150
QPLSPFNLGA TLQSLPSLNF NSFHSLVETK ETCFIREPKT PAPVTDWEGS
160 170 180 190 200
LPLVFNHCRD ASLISRFRPR RDACLGPSPL AASPAFLGQG QVPLNPFSFT
210 220
LSGKSRFSGA GASTPQPLLL HP
Length:222
Mass (Da):24,186
Last modified:July 24, 2013 - v2
Checksum:iC4F240F177FBA93F
GO

Sequence cautioni

The sequence ABD92927.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701L → P in ABD92927 (PubMed:17803967).Curated
Sequence conflicti125 – 1251S → F no nucleotide entry (PubMed:23628413).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ445779 mRNA. Translation: ABD92927.1. Sequence problems.
AC092057 Genomic DNA. No translation available.
UniGeneiHs.720658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ445779 mRNA. Translation: ABD92927.1. Sequence problems.
AC092057 Genomic DNA. No translation available.
UniGeneiHs.720658.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ1W209.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiESRG.
H-InvDBHIX0031228.
HGNCiHGNC:39079. ESRG.
MIMi611473. gene.
neXtProtiNX_Q1W209.
GenAtlasiSearch...

Phylogenomic databases

InParanoidiQ1W209.

Miscellaneous databases

PROiQ1W209.
SOURCEiSearch...

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Transcriptional profiling of human embryonic stem cells and embryoid bodies identifies HESRG, a novel stem cell gene."
    Zhao M., Ren C., Yang H., Feng X., Jiang X., Zhu B., Zhou W., Wang L., Zeng Y., Yao K.
    Biochem. Biophys. Res. Commun. 362:916-922(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY.
    Tissue: Embryonic stem cell.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], NON-AUG INITIATOR START CODON, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiESRG_HUMAN
AccessioniPrimary (citable) accession number: Q1W209
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 24, 2013
Last modified: October 14, 2015
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The initiator methionine is coded by a non-canonical CTG leucine codon.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.