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Protein

Probable methyltransferase BTM2 homolog

Gene

C7orf60

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable S-adenosyl-L-methionine-dependent methyltransferase.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable methyltransferase BTM2 homologUniRule annotation (EC:2.1.1.-UniRule annotation)
Gene namesi
Name:C7orf60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:26475. C7orf60.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162380700.

Polymorphism and mutation databases

BioMutaiC7orf60.
DMDMi121947576.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Probable methyltransferase BTM2 homologPRO_0000321539Add
BLAST

Proteomic databases

PaxDbiQ1RMZ1.
PeptideAtlasiQ1RMZ1.
PRIDEiQ1RMZ1.
TopDownProteomicsiQ1RMZ1.

PTM databases

iPTMnetiQ1RMZ1.
PhosphoSiteiQ1RMZ1.

Expressioni

Gene expression databases

BgeeiENSG00000164603.
CleanExiHS_C7orf60.
ExpressionAtlasiQ1RMZ1. baseline and differential.
GenevisibleiQ1RMZ1. HS.

Organism-specific databases

HPAiHPA044405.
HPA050733.

Interactioni

Protein-protein interaction databases

BioGridi127552. 19 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ1RMZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BMT2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IH2N. Eukaryota.
ENOG410XT5Y. LUCA.
GeneTreeiENSGT00390000010382.
HOGENOMiHOG000007096.
HOVERGENiHBG054033.
InParanoidiQ1RMZ1.
OMAiMAFRKTS.
OrthoDBiEOG091G08HR.
PhylomeDBiQ1RMZ1.
TreeFamiTF324724.

Family and domain databases

HAMAPiMF_03044. BMT2. 1 hit.
InterProiIPR021867. Bmt2.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF11968. DUF3321. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RMZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGAGGRNT ARAQRAGSPN TPPPREQERK LEQEKLSGVV KSVHRRLRKK
60 70 80 90 100
YREVGDFDKI WREHCEDEET LCEYAVAMKN LADNHWAKTC EGEGRIEWCC
110 120 130 140 150
SVCREYFQNG GKRKALEKDE KRAVLATKTT PALNMHESSQ LEGHLTNLSF
160 170 180 190 200
TNPEFITELL QASGKIRLLD VGSCFNPFLK FEEFLTVGID IVPAVESVYK
210 220 230 240 250
CDFLNLQLQQ PLQLAQDAID AFLKQLKNPI DSLPGELFHV VVFSLLLSYF
260 270 280 290 300
PSPYQRWICC KKAHELLVLN GLLLIITPDS SHQNRHAMMM KSWKIAIESL
310 320 330 340 350
GFKRFKYSKF SHMHLMAFRK ISLKTTSDLV SRNYPGMLYI PQDFNSIEDE
360 370 380 390 400
EYSNPSCYVR SDIEDEQLAY GFTELPDAPY DSDSGESQAS SIPFYELEDP

ILLLS
Length:405
Mass (Da):46,324
Last modified:May 16, 2006 - v1
Checksum:i5C19614953ABD670
GO

Sequence cautioni

The sequence BAB71169 differs from that shown. Reason: Frameshift at position 259. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti219 – 2191I → T in BAB71169 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056380 mRNA. Translation: BAB71169.1. Frameshift.
CH471070 Genomic DNA. Translation: EAW83474.1.
BC114615 mRNA. Translation: AAI14616.1.
AL834437 mRNA. Translation: CAD39097.1.
CCDSiCCDS43634.1.
RefSeqiNP_689769.2. NM_152556.2.
UniGeneiHs.489734.

Genome annotation databases

EnsembliENST00000297145; ENSP00000297145; ENSG00000164603.
GeneIDi154743.
KEGGihsa:154743.
UCSCiuc003vgo.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056380 mRNA. Translation: BAB71169.1. Frameshift.
CH471070 Genomic DNA. Translation: EAW83474.1.
BC114615 mRNA. Translation: AAI14616.1.
AL834437 mRNA. Translation: CAD39097.1.
CCDSiCCDS43634.1.
RefSeqiNP_689769.2. NM_152556.2.
UniGeneiHs.489734.

3D structure databases

ProteinModelPortaliQ1RMZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127552. 19 interactions.

PTM databases

iPTMnetiQ1RMZ1.
PhosphoSiteiQ1RMZ1.

Polymorphism and mutation databases

BioMutaiC7orf60.
DMDMi121947576.

Proteomic databases

PaxDbiQ1RMZ1.
PeptideAtlasiQ1RMZ1.
PRIDEiQ1RMZ1.
TopDownProteomicsiQ1RMZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297145; ENSP00000297145; ENSG00000164603.
GeneIDi154743.
KEGGihsa:154743.
UCSCiuc003vgo.2. human.

Organism-specific databases

CTDi154743.
GeneCardsiC7orf60.
H-InvDBHIX0007009.
HGNCiHGNC:26475. C7orf60.
HPAiHPA044405.
HPA050733.
neXtProtiNX_Q1RMZ1.
PharmGKBiPA162380700.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH2N. Eukaryota.
ENOG410XT5Y. LUCA.
GeneTreeiENSGT00390000010382.
HOGENOMiHOG000007096.
HOVERGENiHBG054033.
InParanoidiQ1RMZ1.
OMAiMAFRKTS.
OrthoDBiEOG091G08HR.
PhylomeDBiQ1RMZ1.
TreeFamiTF324724.

Miscellaneous databases

GenomeRNAii154743.
PROiQ1RMZ1.

Gene expression databases

BgeeiENSG00000164603.
CleanExiHS_C7orf60.
ExpressionAtlasiQ1RMZ1. baseline and differential.
GenevisibleiQ1RMZ1. HS.

Family and domain databases

HAMAPiMF_03044. BMT2. 1 hit.
InterProiIPR021867. Bmt2.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF11968. DUF3321. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBMT2_HUMAN
AccessioniPrimary (citable) accession number: Q1RMZ1
Secondary accession number(s): Q8N3D0, Q96MV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 16, 2006
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.