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Protein

S-adenosylmethionine sensor upstream of mTORC1

Gene

BMT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential).UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei172S-adenosyl-L-methionine1 Publication1
Binding sitei190S-adenosyl-L-methionine1 Publication1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine sensor upstream of mTORC11 Publication
Alternative name(s):
Probable methyltransferase BMT2 homologUniRule annotation (EC:2.1.1.-UniRule annotation)
Gene namesi
Name:BMT2Imported
Synonyms:C7orf60Imported, SAMTOR1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000164603.11.
HGNCiHGNC:26475. BMT2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164603.
PharmGKBiPA162380700.

Polymorphism and mutation databases

BioMutaiC7orf60.
DMDMi121947576.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003215391 – 405S-adenosylmethionine sensor upstream of mTORC1Add BLAST405

Proteomic databases

PaxDbiQ1RMZ1.
PeptideAtlasiQ1RMZ1.
PRIDEiQ1RMZ1.
TopDownProteomicsiQ1RMZ1.

PTM databases

iPTMnetiQ1RMZ1.
PhosphoSitePlusiQ1RMZ1.

Expressioni

Gene expression databases

BgeeiENSG00000164603.
CleanExiHS_C7orf60.
ExpressionAtlasiQ1RMZ1. baseline and differential.
GenevisibleiQ1RMZ1. HS.

Organism-specific databases

HPAiHPA044405.
HPA050733.

Interactioni

Subunit structurei

Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine (PubMed:29123071). Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine (PubMed:29123071).1 Publication

Protein-protein interaction databases

BioGridi127552. 20 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ1RMZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BMT2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IH2N. Eukaryota.
ENOG410XT5Y. LUCA.
GeneTreeiENSGT00390000010382.
HOGENOMiHOG000007096.
HOVERGENiHBG054033.
InParanoidiQ1RMZ1.
OMAiMAFRKTS.
OrthoDBiEOG091G08HR.
PhylomeDBiQ1RMZ1.
TreeFamiTF324724.

Family and domain databases

HAMAPiMF_03044. BMT2. 1 hit.
InterProiView protein in InterPro
IPR021867. Bmt2.
IPR029063. SAM-dependent_MTases.
PANTHERiPTHR21008. PTHR21008. 1 hit.
PfamiView protein in Pfam
PF11968. Bmt2. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RMZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGAGGRNT ARAQRAGSPN TPPPREQERK LEQEKLSGVV KSVHRRLRKK
60 70 80 90 100
YREVGDFDKI WREHCEDEET LCEYAVAMKN LADNHWAKTC EGEGRIEWCC
110 120 130 140 150
SVCREYFQNG GKRKALEKDE KRAVLATKTT PALNMHESSQ LEGHLTNLSF
160 170 180 190 200
TNPEFITELL QASGKIRLLD VGSCFNPFLK FEEFLTVGID IVPAVESVYK
210 220 230 240 250
CDFLNLQLQQ PLQLAQDAID AFLKQLKNPI DSLPGELFHV VVFSLLLSYF
260 270 280 290 300
PSPYQRWICC KKAHELLVLN GLLLIITPDS SHQNRHAMMM KSWKIAIESL
310 320 330 340 350
GFKRFKYSKF SHMHLMAFRK ISLKTTSDLV SRNYPGMLYI PQDFNSIEDE
360 370 380 390 400
EYSNPSCYVR SDIEDEQLAY GFTELPDAPY DSDSGESQAS SIPFYELEDP

ILLLS
Length:405
Mass (Da):46,324
Last modified:May 16, 2006 - v1
Checksum:i5C19614953ABD670
GO

Sequence cautioni

The sequence BAB71169 differs from that shown. Reason: Frameshift at position 259.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219I → T in BAB71169 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056380 mRNA. Translation: BAB71169.1. Frameshift.
CH471070 Genomic DNA. Translation: EAW83474.1.
BC114615 mRNA. Translation: AAI14616.1.
AL834437 mRNA. Translation: CAD39097.1.
CCDSiCCDS43634.1.
RefSeqiNP_689769.2. NM_152556.2.
UniGeneiHs.489734.

Genome annotation databases

EnsembliENST00000297145; ENSP00000297145; ENSG00000164603.
GeneIDi154743.
KEGGihsa:154743.
UCSCiuc003vgo.2. human.

Similar proteinsi

Entry informationi

Entry nameiSAMTR_HUMAN
AccessioniPrimary (citable) accession number: Q1RMZ1
Secondary accession number(s): Q8N3D0, Q96MV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 16, 2006
Last modified: January 31, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families