Q1RMX3 (B2CL2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bcl-2-like protein 2
Short name=Bcl2-L-2

Alternative name(s):
Apoptosis regulator Bcl-W

Gene names

Name:

BCL2L2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX By similarity.
Subcellular location	Mitochondrion membrane; Peripheral membrane protein By similarity. Note: Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane By similarity.
Domain	The BH4 motif seems to be involved in the anti-apoptotic function By similarity. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2 By similarity.
Sequence similarities	Belongs to the Bcl-2 family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Membrane Mitochondrion
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of apoptotic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Bcl-2-like protein 2		PRO_0000247324
Regions
	Motif	9 – 29	21	BH4
	Motif	85 – 104	20	BH1
	Motif	136 – 151	16	BH2
Amino acid modifications
	Modified residue	192	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1RMX3 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 3792243A50281761	FASTA	193	20,774
	10 20 30 40 50 60 MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG DEFETRFRRT 70 80 90 100 110 120 FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF VFGAALCAES VNKEMEPLVG 130 140 150 160 170 180 QVQEWMVAYL ETRLADWIHS SGGWAEFTAL YGDGALEEAR RLREGNWASV RTVLTGAVAL 190 GALVTVGAFF ASK

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Uterus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC114652 mRNA. Translation: AAI14653.1.
IPI	IPI00688324.
RefSeq	NP_001070001.1. NM_001076533.1.
UniGene	Bt.53488.
3D structure databases
ProteinModelPortal	Q1RMX3.
SMR	Q1RMX3. Positions 1-183.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RMX3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000026248; ENSBTAP00000026248; ENSBTAG00000019692.
GeneID	767601.
KEGG	bta:767601.
Organism-specific databases
CTD	599.
Phylogenomic databases
InParanoid	Q1RMX3.
OMA	RMATPAS.
OrthoDB	EOG4RBQKR.
Family and domain databases
InterPro	IPR013280. Apop_reg_BclW. IPR002475. Bcl2-like_apoptosis. IPR000712. Bcl2_BH. IPR020717. Bcl2_BH1_motif_CS. IPR020726. Bcl2_BH2_motif_CS. IPR003093. Bcl2_BH4. IPR020731. Bcl2_BH4_motif_CS. [Graphical view]
KO	K02163.
Pfam	PF00452. Bcl-2. 1 hit. PF02180. BH4. 1 hit. [Graphical view]
PRINTS	PR01865. APOPREGBCLW. PR01862. BCL2FAMILY.
SMART	SM00337. BCL. 1 hit. SM00265. BH4. 1 hit. [Graphical view]
PROSITE	PS50062. BCL2_FAMILY. 1 hit. PS01080. BH1. 1 hit. PS01258. BH2. 1 hit. PS01260. BH4_1. 1 hit. PS50063. BH4_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B2CL2_BOVIN

Accession

Primary (citable) accession number: Q1RMX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	May 16, 2006
Last modified:	November 16, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program