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Protein

Bcl-2-like protein 2

Gene

BCL2L2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 2
Short name:
Bcl2-L-2
Alternative name(s):
Apoptosis regulator Bcl-W
Gene namesi
Name:BCL2L2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002473242 – 193Bcl-2-like protein 2Add BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ1RMX3.
PRIDEiQ1RMX3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000019692.

Interactioni

Subunit structurei

Interacts with HIF3A (via C-terminus domain). Interacts with BOP.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026248.

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 24Combined sources17
Beta strandi30 – 32Combined sources3
Beta strandi35 – 37Combined sources3
Helixi41 – 56Combined sources16
Beta strandi57 – 59Combined sources3
Helixi60 – 67Combined sources8
Turni72 – 74Combined sources3
Helixi75 – 86Combined sources12
Turni87 – 89Combined sources3
Helixi93 – 112Combined sources20
Helixi118 – 132Combined sources15
Helixi135 – 140Combined sources6
Helixi143 – 151Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4K5AX-ray1.50A2-171[»]
4K5BX-ray1.85C/D2-171[»]
ProteinModelPortaliQ1RMX3.
SMRiQ1RMX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 29BH4Add BLAST21
Motifi85 – 104BH1Add BLAST20
Motifi136 – 151BH2Add BLAST16

Domaini

The BH4 motif seems to be involved in the anti-apoptotic function.By similarity
The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2 (By similarity).By similarity

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGiKOG4209. Eukaryota.
ENOG4111PFV. LUCA.
GeneTreeiENSGT00530000062935.
HOGENOMiHOG000056452.
InParanoidiQ1RMX3.
KOiK02163.
OMAiVQDWMVT.
OrthoDBiEOG091G0PAK.
TreeFamiTF315834.

Family and domain databases

InterProiIPR013280. Apop_reg_BclW.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR003093. Bcl2_BH4.
IPR020731. Bcl2_BH4_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF13. PTHR11256:SF13. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
[Graphical view]
PRINTSiPR01865. APOPREGBCLW.
PR01862. BCL2FAMILY.
SMARTiSM00265. BH4. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01260. BH4_1. 1 hit.
PS50063. BH4_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1RMX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG
60 70 80 90 100
DEFETRFRRT FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF
110 120 130 140 150
VFGAALCAES VNKEMEPLVG QVQEWMVAYL ETRLADWIHS SGGWAEFTAL
160 170 180 190
YGDGALEEAR RLREGNWASV RTVLTGAVAL GALVTVGAFF ASK
Length:193
Mass (Da):20,774
Last modified:May 16, 2006 - v1
Checksum:i3792243A50281761
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114652 mRNA. Translation: AAI14653.1.
RefSeqiNP_001070001.1. NM_001076533.1.
XP_005211456.1. XM_005211399.3.
XP_015328534.1. XM_015473048.1.
UniGeneiBt.53488.

Genome annotation databases

EnsembliENSBTAT00000026248; ENSBTAP00000026248; ENSBTAG00000019692.
GeneIDi767601.
KEGGibta:767601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114652 mRNA. Translation: AAI14653.1.
RefSeqiNP_001070001.1. NM_001076533.1.
XP_005211456.1. XM_005211399.3.
XP_015328534.1. XM_015473048.1.
UniGeneiBt.53488.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4K5AX-ray1.50A2-171[»]
4K5BX-ray1.85C/D2-171[»]
ProteinModelPortaliQ1RMX3.
SMRiQ1RMX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026248.

Proteomic databases

PaxDbiQ1RMX3.
PRIDEiQ1RMX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026248; ENSBTAP00000026248; ENSBTAG00000019692.
GeneIDi767601.
KEGGibta:767601.

Organism-specific databases

CTDi599.

Phylogenomic databases

eggNOGiKOG4209. Eukaryota.
ENOG4111PFV. LUCA.
GeneTreeiENSGT00530000062935.
HOGENOMiHOG000056452.
InParanoidiQ1RMX3.
KOiK02163.
OMAiVQDWMVT.
OrthoDBiEOG091G0PAK.
TreeFamiTF315834.

Gene expression databases

BgeeiENSBTAG00000019692.

Family and domain databases

InterProiIPR013280. Apop_reg_BclW.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR003093. Bcl2_BH4.
IPR020731. Bcl2_BH4_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF13. PTHR11256:SF13. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
[Graphical view]
PRINTSiPR01865. APOPREGBCLW.
PR01862. BCL2FAMILY.
SMARTiSM00265. BH4. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01260. BH4_1. 1 hit.
PS50063. BH4_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2CL2_BOVIN
AccessioniPrimary (citable) accession number: Q1RMX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 16, 2006
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.