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Protein

CTD nuclear envelope phosphatase 1

Gene

CTDNEP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-BTA-4419969. Depolymerisation of the Nuclear Lamina.

Names & Taxonomyi

Protein namesi
Recommended name:
CTD nuclear envelope phosphatase 1 (EC:3.1.3.16)
Alternative name(s):
Serine/threonine-protein phosphatase dullard
Gene namesi
Name:CTDNEP1
Synonyms:DULLARD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 29HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002979661 – 244CTD nuclear envelope phosphatase 1Add BLAST244

Proteomic databases

PaxDbiQ1RMV9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000019443.

Interactioni

Subunit structurei

Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025896.

Structurei

3D structure databases

ProteinModelPortaliQ1RMV9.
SMRiQ1RMV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 224FCP1 homologyPROSITE-ProRule annotationAdd BLAST168

Sequence similaritiesi

Belongs to the dullard family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1605. Eukaryota.
COG5190. LUCA.
GeneTreeiENSGT00550000075053.
HOVERGENiHBG098153.
InParanoidiQ1RMV9.
KOiK17617.
OMAiSRIWGFI.
OrthoDBiEOG091G0GIO.
TreeFamiTF313962.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR011948. Dullard_phosphatase.
IPR004274. FCP1_dom.
IPR036412. HAD-like_sf.
IPR023214. HAD_sf.
PfamiView protein in Pfam
PF03031. NIF. 1 hit.
SMARTiView protein in SMART
SM00577. CPDc. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiView protein in PROSITE
PS50969. FCP1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RMV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRTQCLLGL RTFVAFAAKL WSFFIYLLRR QIRTVIQYQT VRYDILPLSP
60 70 80 90 100
VSRNRLSQVK RKILVLDLDE TLIHSHHDGV LRPTVRPGTP PDFILKVVID
110 120 130 140 150
KHPVRFFVHK RPHVDFFLEV VSQWYELVVF TASMEIYGSA VADKLDNSRS
160 170 180 190 200
ILKRRYYRQH CTLELGSYIK DLSVVHSDLS SIVILDNSPG AYRSHPDNAI
210 220 230 240
PIKSWFSDPS DTALLNLLPM LDALRFTADV RSVLSRNLHQ HRLW
Length:244
Mass (Da):28,393
Last modified:May 16, 2006 - v1
Checksum:i44494AC37D7E2F30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114677 mRNA. Translation: AAI14678.1.
RefSeqiNP_001039491.1. NM_001046026.1.
UniGeneiBt.27121.

Genome annotation databases

EnsembliENSBTAT00000025896; ENSBTAP00000025896; ENSBTAG00000019443.
GeneIDi509192.
KEGGibta:509192.

Similar proteinsi

Entry informationi

Entry nameiCNEP1_BOVIN
AccessioniPrimary (citable) accession number: Q1RMV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: May 16, 2006
Last modified: October 25, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families