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Q1RMV9

- CNEP1_BOVIN

UniProt

Q1RMV9 - CNEP1_BOVIN

Protein

CTD nuclear envelope phosphatase 1

Gene

CTDNEP1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. protein serine/threonine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. nuclear envelope organization Source: UniProtKB
    2. positive regulation of triglyceride biosynthetic process Source: UniProtKB
    3. protein dephosphorylation Source: UniProtKB
    4. protein localization to nucleus Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    ReactomeiREACT_221009. Depolymerisation of the Nuclear Lamina.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CTD nuclear envelope phosphatase 1 (EC:3.1.3.16)
    Alternative name(s):
    Serine/threonine-protein phosphatase dullard
    Gene namesi
    Name:CTDNEP1
    Synonyms:DULLARD
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 19

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. endoplasmic reticulum membrane Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW
    4. Nem1-Spo7 phosphatase complex Source: UniProtKB
    5. nuclear envelope Source: UniProtKB
    6. nuclear membrane Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 244244CTD nuclear envelope phosphatase 1PRO_0000297966Add
    BLAST

    Proteomic databases

    PRIDEiQ1RMV9.

    Interactioni

    Subunit structurei

    Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000025896.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RMV9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2923HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini57 – 224168FCP1 homologyPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the dullard family.Curated
    Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5190.
    GeneTreeiENSGT00550000075053.
    HOVERGENiHBG098153.
    InParanoidiQ1RMV9.
    KOiK17617.
    OMAiLLGIRTF.
    OrthoDBiEOG7MKW6W.
    TreeFamiTF313962.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR011948. Dullard_phosphatase.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view]
    PfamiPF03031. NIF. 1 hit.
    [Graphical view]
    SMARTiSM00577. CPDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
    PROSITEiPS50969. FCP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1RMV9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMRTQCLLGL RTFVAFAAKL WSFFIYLLRR QIRTVIQYQT VRYDILPLSP    50
    VSRNRLSQVK RKILVLDLDE TLIHSHHDGV LRPTVRPGTP PDFILKVVID 100
    KHPVRFFVHK RPHVDFFLEV VSQWYELVVF TASMEIYGSA VADKLDNSRS 150
    ILKRRYYRQH CTLELGSYIK DLSVVHSDLS SIVILDNSPG AYRSHPDNAI 200
    PIKSWFSDPS DTALLNLLPM LDALRFTADV RSVLSRNLHQ HRLW 244
    Length:244
    Mass (Da):28,393
    Last modified:May 16, 2006 - v1
    Checksum:i44494AC37D7E2F30
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC114677 mRNA. Translation: AAI14678.1.
    RefSeqiNP_001039491.1. NM_001046026.1.
    UniGeneiBt.27121.

    Genome annotation databases

    EnsembliENSBTAT00000025896; ENSBTAP00000025896; ENSBTAG00000019443.
    GeneIDi509192.
    KEGGibta:509192.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC114677 mRNA. Translation: AAI14678.1 .
    RefSeqi NP_001039491.1. NM_001046026.1.
    UniGenei Bt.27121.

    3D structure databases

    ProteinModelPortali Q1RMV9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000025896.

    Proteomic databases

    PRIDEi Q1RMV9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000025896 ; ENSBTAP00000025896 ; ENSBTAG00000019443 .
    GeneIDi 509192.
    KEGGi bta:509192.

    Organism-specific databases

    CTDi 23399.

    Phylogenomic databases

    eggNOGi COG5190.
    GeneTreei ENSGT00550000075053.
    HOVERGENi HBG098153.
    InParanoidi Q1RMV9.
    KOi K17617.
    OMAi LLGIRTF.
    OrthoDBi EOG7MKW6W.
    TreeFami TF313962.

    Enzyme and pathway databases

    Reactomei REACT_221009. Depolymerisation of the Nuclear Lamina.

    Miscellaneous databases

    NextBioi 20868866.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR011948. Dullard_phosphatase.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view ]
    Pfami PF03031. NIF. 1 hit.
    [Graphical view ]
    SMARTi SM00577. CPDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR02251. HIF-SF_euk. 1 hit.
    PROSITEi PS50969. FCP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Uterus.

    Entry informationi

    Entry nameiCNEP1_BOVIN
    AccessioniPrimary (citable) accession number: Q1RMV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3