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Q1RMV9

- CNEP1_BOVIN

UniProt

Q1RMV9 - CNEP1_BOVIN

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Protein
CTD nuclear envelope phosphatase 1
Gene
CTDNEP1, DULLARD
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. protein serine/threonine phosphatase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. nuclear envelope organization Source: UniProtKB
  2. positive regulation of triglyceride biosynthetic process Source: UniProtKB
  3. protein dephosphorylation Source: UniProtKB
  4. protein localization to nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiREACT_221009. Depolymerisation of the Nuclear Lamina.

Names & Taxonomyi

Protein namesi
Recommended name:
CTD nuclear envelope phosphatase 1 (EC:3.1.3.16)
Alternative name(s):
Serine/threonine-protein phosphatase dullard
Gene namesi
Name:CTDNEP1
Synonyms:DULLARD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 19

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2923Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Nem1-Spo7 phosphatase complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. endoplasmic reticulum membrane Source: UniProtKB
  4. integral component of membrane Source: UniProtKB-KW
  5. nuclear envelope Source: UniProtKB
  6. nuclear membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244CTD nuclear envelope phosphatase 1
PRO_0000297966Add
BLAST

Proteomic databases

PRIDEiQ1RMV9.

Interactioni

Subunit structurei

Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2 By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025896.

Structurei

3D structure databases

ProteinModelPortaliQ1RMV9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 224168FCP1 homology
Add
BLAST

Sequence similaritiesi

Belongs to the dullard family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5190.
GeneTreeiENSGT00550000075053.
HOVERGENiHBG098153.
InParanoidiQ1RMV9.
KOiK17617.
OMAiLLGIRTF.
OrthoDBiEOG7MKW6W.
TreeFamiTF313962.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RMV9-1 [UniParc]FASTAAdd to Basket

« Hide

MMRTQCLLGL RTFVAFAAKL WSFFIYLLRR QIRTVIQYQT VRYDILPLSP    50
VSRNRLSQVK RKILVLDLDE TLIHSHHDGV LRPTVRPGTP PDFILKVVID 100
KHPVRFFVHK RPHVDFFLEV VSQWYELVVF TASMEIYGSA VADKLDNSRS 150
ILKRRYYRQH CTLELGSYIK DLSVVHSDLS SIVILDNSPG AYRSHPDNAI 200
PIKSWFSDPS DTALLNLLPM LDALRFTADV RSVLSRNLHQ HRLW 244
Length:244
Mass (Da):28,393
Last modified:May 16, 2006 - v1
Checksum:i44494AC37D7E2F30
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC114677 mRNA. Translation: AAI14678.1.
RefSeqiNP_001039491.1. NM_001046026.1.
UniGeneiBt.27121.

Genome annotation databases

EnsembliENSBTAT00000025896; ENSBTAP00000025896; ENSBTAG00000019443.
GeneIDi509192.
KEGGibta:509192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC114677 mRNA. Translation: AAI14678.1 .
RefSeqi NP_001039491.1. NM_001046026.1.
UniGenei Bt.27121.

3D structure databases

ProteinModelPortali Q1RMV9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000025896.

Proteomic databases

PRIDEi Q1RMV9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000025896 ; ENSBTAP00000025896 ; ENSBTAG00000019443 .
GeneIDi 509192.
KEGGi bta:509192.

Organism-specific databases

CTDi 23399.

Phylogenomic databases

eggNOGi COG5190.
GeneTreei ENSGT00550000075053.
HOVERGENi HBG098153.
InParanoidi Q1RMV9.
KOi K17617.
OMAi LLGIRTF.
OrthoDBi EOG7MKW6W.
TreeFami TF313962.

Enzyme and pathway databases

Reactomei REACT_221009. Depolymerisation of the Nuclear Lamina.

Miscellaneous databases

NextBioi 20868866.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view ]
Pfami PF03031. NIF. 1 hit.
[Graphical view ]
SMARTi SM00577. CPDc. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR02251. HIF-SF_euk. 1 hit.
PROSITEi PS50969. FCP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiCNEP1_BOVIN
AccessioniPrimary (citable) accession number: Q1RMV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: May 16, 2006
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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