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Protein

Neuropeptide Y receptor type 1

Gene

NPY1R

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 1
Short name:
NPY1-R
Gene namesi
Name:NPY1R
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 65Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini66 – 76CytoplasmicSequence analysisAdd BLAST11
Transmembranei77 – 97Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini98 – 116ExtracellularSequence analysisAdd BLAST19
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 154CytoplasmicSequence analysisAdd BLAST17
Transmembranei155 – 175Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini176 – 211ExtracellularSequence analysisAdd BLAST36
Transmembranei212 – 232Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini233 – 260CytoplasmicSequence analysisAdd BLAST28
Transmembranei261 – 281Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini282 – 299ExtracellularSequence analysisAdd BLAST18
Transmembranei300 – 320Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini321 – 383CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002828251 – 383Neuropeptide Y receptor type 1Add BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi113 ↔ 198PROSITE-ProRule annotation
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi338S-palmitoyl cysteineSequence analysis1
Modified residuei368PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ1RMU8.

Expressioni

Gene expression databases

BgeeiENSBTAG00000047586.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055219.

Structurei

3D structure databases

ProteinModelPortaliQ1RMU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00900000140797.
HOVERGENiHBG105676.
InParanoidiQ1RMU8.
KOiK04204.
OMAiQVENHSI.
OrthoDBiEOG091G0A5E.
TreeFamiTF315303.

Family and domain databases

CDDicd15395. 7tmA_NPY1R. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
PANTHERiPTHR43916:SF5. PTHR43916:SF5. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RMU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTSFSQVE NHSIYYNFSE KNSRFLAFEN DDCHLPLAMI FTLALAYGAV
60 70 80 90 100
IILGVSGNLA LIIIILKQKE MRNVTNILIV NLSFSDLLVA IMCLPFTFVY
110 120 130 140 150
TLMDHWVFGE AMCKLNPFVQ CVSITVSIFS LVLIAVERHQ LIINPRGWRP
160 170 180 190 200
NNRHAYVGIA VIWVLAVASS LPFLIYQVLT DEPFQNVTLD AFKDKYVCFD
210 220 230 240 250
KFPSDSHRLS YTTLLLVLQY FGPLCFIFIC YFKIYVRLKR RNSMMDKMRD
260 270 280 290 300
NKYRSSEAKR INIMLLSIVV AFAVCWLPLT IFNTVFDWDH QIIATCNHNL
310 320 330 340 350
LFLLCHLTAM ISTCVNPIFY GFLNKNFQRD LQFFFSFCDF RSRDDDYETI
360 370 380
AMSTMHTDVS KTSLKQASPV ALKKIHTDDN EKI
Length:383
Mass (Da):44,291
Last modified:May 16, 2006 - v1
Checksum:i1CCF6F147DBCCA14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114695 mRNA. Translation: AAI14696.1.
RefSeqiNP_001039363.1. NM_001045898.1.
XP_005207617.1. XM_005207560.3.
UniGeneiBt.33181.

Genome annotation databases

EnsembliENSBTAT00000066076; ENSBTAP00000055219; ENSBTAG00000047586.
GeneIDi504813.
KEGGibta:504813.

Similar proteinsi

Entry informationi

Entry nameiNPY1R_BOVIN
AccessioniPrimary (citable) accession number: Q1RMU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 16, 2006
Last modified: November 22, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families