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Protein

Sesquipedalian-2

Gene

FAM109B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Sesquipedalian-2
Short name:
Ses2
Alternative name(s):
27 kDa inositol polyphosphate phosphatase interacting protein B
Short name:
IPIP27B
Gene namesi
Name:FAM109B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:28715 PHETA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002541321 – 259Sesquipedalian-2Add BLAST259

Proteomic databases

PaxDbiQ1RMU7
PRIDEiQ1RMU7

Expressioni

Gene expression databases

BgeeiENSBTAG00000009507

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FAM109A. Interacts with OCRL and INPP5B (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012510

Structurei

3D structure databases

ProteinModelPortaliQ1RMU7
SMRiQ1RMU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 121PHPROSITE-ProRule annotationAdd BLAST105

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili124 – 149Sequence analysisAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi223 – 235F&HAdd BLAST13

Domaini

The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B.By similarity

Sequence similaritiesi

Belongs to the sesquipedalian family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IX8V Eukaryota
ENOG4111I0C LUCA
GeneTreeiENSGT00440000034671
HOVERGENiHBG061708
InParanoidiQ1RMU7
OMAiWGGPGTP
OrthoDBiEOG091G0IU5
TreeFamiTF326731

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q1RMU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNERSVAH YALSDSPADH TGFLRTWGGA GTPPTPSGAG RKCWFVLKGN
60 70 80 90 100
LLFSFESREG RAPLSLVVLE GCTVELAEAP VPEEFAFAIR FDAPGVRPHL
110 120 130 140 150
LAADGPAAQE AWVKALSRAS FGYMRLVVRE LESQLREARH SLDLHRRSSW
160 170 180 190 200
KAVSSRCKPQ APDRWSPGLE NGHSLSRDCS PMGLVEEGGS RPAGRGLAEW
210 220 230 240 250
ELQGPASLLL GRGQSPVSPE TSCFSTLHEW YGREIMELRR AWLQRAQENQ

PECKDQDRP
Length:259
Mass (Da):28,626
Last modified:May 16, 2006 - v1
Checksum:i8936E7AB4C01C930
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114700 mRNA Translation: AAI14701.1
RefSeqiNP_001039401.2, NM_001045936.2
UniGeneiBt.5202

Genome annotation databases

EnsembliENSBTAT00000012510; ENSBTAP00000012510; ENSBTAG00000009507
GeneIDi506148
KEGGibta:506148

Similar proteinsi

Entry informationi

Entry nameiSESQ2_BOVIN
AccessioniPrimary (citable) accession number: Q1RMU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 16, 2006
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health