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Protein

Sesquipedalian-2

Gene

FAM109B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sesquipedalian-2
Short name:
Ses2
Alternative name(s):
27 kDa inositol polyphosphate phosphatase interacting protein B
Short name:
IPIP27B
Gene namesi
Name:FAM109B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Sesquipedalian-2PRO_0000254132Add
BLAST

Proteomic databases

PaxDbiQ1RMU7.
PRIDEiQ1RMU7.

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FAM109A. Interacts with OCRL and INPP5B (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ1RMU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 121105PHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili124 – 14926Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi223 – 23513F&HAdd
BLAST

Domaini

The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B.By similarity

Sequence similaritiesi

Belongs to the sesquipedalian family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IX8V. Eukaryota.
ENOG4111I0C. LUCA.
GeneTreeiENSGT00440000034671.
HOVERGENiHBG061708.
InParanoidiQ1RMU7.
OMAiLRTWGGP.
OrthoDBiEOG7966HQ.
TreeFamiTF326731.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RMU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNERSVAH YALSDSPADH TGFLRTWGGA GTPPTPSGAG RKCWFVLKGN
60 70 80 90 100
LLFSFESREG RAPLSLVVLE GCTVELAEAP VPEEFAFAIR FDAPGVRPHL
110 120 130 140 150
LAADGPAAQE AWVKALSRAS FGYMRLVVRE LESQLREARH SLDLHRRSSW
160 170 180 190 200
KAVSSRCKPQ APDRWSPGLE NGHSLSRDCS PMGLVEEGGS RPAGRGLAEW
210 220 230 240 250
ELQGPASLLL GRGQSPVSPE TSCFSTLHEW YGREIMELRR AWLQRAQENQ

PECKDQDRP
Length:259
Mass (Da):28,626
Last modified:May 16, 2006 - v1
Checksum:i8936E7AB4C01C930
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114700 mRNA. Translation: AAI14701.1.
RefSeqiNP_001039401.2. NM_001045936.2.
UniGeneiBt.5202.

Genome annotation databases

EnsembliENSBTAT00000012510; ENSBTAP00000012510; ENSBTAG00000009507.
GeneIDi506148.
KEGGibta:506148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114700 mRNA. Translation: AAI14701.1.
RefSeqiNP_001039401.2. NM_001045936.2.
UniGeneiBt.5202.

3D structure databases

ProteinModelPortaliQ1RMU7.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ1RMU7.
PRIDEiQ1RMU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000012510; ENSBTAP00000012510; ENSBTAG00000009507.
GeneIDi506148.
KEGGibta:506148.

Organism-specific databases

CTDi150368.

Phylogenomic databases

eggNOGiENOG410IX8V. Eukaryota.
ENOG4111I0C. LUCA.
GeneTreeiENSGT00440000034671.
HOVERGENiHBG061708.
InParanoidiQ1RMU7.
OMAiLRTWGGP.
OrthoDBiEOG7966HQ.
TreeFamiTF326731.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiSESQ2_BOVIN
AccessioniPrimary (citable) accession number: Q1RMU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 16, 2006
Last modified: June 8, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.