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Protein

Erlin-2

Gene

ERLIN2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Erlin-2
Alternative name(s):
Endoplasmic reticulum lipid raft-associated protein 2
Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
Short name:
SPFH domain-containing protein 2
Gene namesi
Name:ERLIN2
Synonyms:SPFH2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 27

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33CytoplasmicSequence analysis
Transmembranei4 – 2421HelicalSequence analysisAdd
BLAST
Topological domaini25 – 338314LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Erlin-2PRO_0000288559Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ1RMU4.
PRIDEiQ1RMU4.

Interactioni

Subunit structurei

Forms a heteromeric complex with ERLIN1. In complex with ERLIN1, interacts with RNF170. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination. Interacts with SCAP, INSIG1, SREBF1 and SREBF2 under cholesterol sufficiency conditions; indicative for an association with the SCAP-SREBP-INSIG complex. Probably part of an AMFR/gp78 and INSIG1-containing ubiquitin ligase complex involved in ERAD of HMGCR. Interacts with TMUB1; TMUB1 bridges the association with AMFR. Interacts with SYVN1 and RNF139. Interacts with TMEM259 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039591.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni177 – 309133Interaction with ERLIN1By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the band 7/mec-2 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2962. Eukaryota.
ENOG410XQSH. LUCA.
GeneTreeiENSGT00390000014666.
HOGENOMiHOG000251613.
HOVERGENiHBG050934.
InParanoidiQ1RMU4.
OMAiNMFVDSA.
OrthoDBiEOG7Z69D1.
TreeFamiTF313059.

Family and domain databases

InterProiIPR001107. Band_7.
IPR033294. Erlin1/2.
[Graphical view]
PANTHERiPTHR15351. PTHR15351. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
SMARTiSM00244. PHB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RMU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLGAVVAV AASFFCASLF SAVHKIEEGH IGVYYRGGAL LTSTSGPGFH
60 70 80 90 100
LMLPFITSYK SVQTTLQTDE VKNVPCGTSG GVMIYFDRIE VVNFLVPHAV
110 120 130 140 150
YDIVKNYTAD YDKALIFNKI HHELNQFCSV HTLQEVYIEL FDQIDENLKL
160 170 180 190 200
ALQQDLTSMA PGLVIQAVRV TKPNIPEAIR RNYELMESEK TKLLIAAQKQ
210 220 230 240 250
KVVEKEAETE RKKALIEAEK VAQVAEITFG QKVMEKETEK RISEIEDAAF
260 270 280 290 300
LAREKAKADA ECYTAMKIAE ANKLKLTPEY LQLMKYKAIA SNSKIYFGKD
310 320 330
IPNMFMDSAG GVGKQFEGLA DKLSFVLEDE PMEADSEN
Length:338
Mass (Da):37,730
Last modified:May 16, 2006 - v1
Checksum:iE0116C0D47221EE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114707 mRNA. Translation: AAI14708.1.
RefSeqiNP_001040041.1. NM_001046576.1.
XP_005226183.1. XM_005226126.3.
UniGeneiBt.1734.

Genome annotation databases

EnsembliENSBTAT00000039803; ENSBTAP00000039591; ENSBTAG00000017831.
GeneIDi616278.
KEGGibta:616278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114707 mRNA. Translation: AAI14708.1.
RefSeqiNP_001040041.1. NM_001046576.1.
XP_005226183.1. XM_005226126.3.
UniGeneiBt.1734.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039591.

Proteomic databases

PaxDbiQ1RMU4.
PRIDEiQ1RMU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000039803; ENSBTAP00000039591; ENSBTAG00000017831.
GeneIDi616278.
KEGGibta:616278.

Organism-specific databases

CTDi11160.

Phylogenomic databases

eggNOGiKOG2962. Eukaryota.
ENOG410XQSH. LUCA.
GeneTreeiENSGT00390000014666.
HOGENOMiHOG000251613.
HOVERGENiHBG050934.
InParanoidiQ1RMU4.
OMAiNMFVDSA.
OrthoDBiEOG7Z69D1.
TreeFamiTF313059.

Family and domain databases

InterProiIPR001107. Band_7.
IPR033294. Erlin1/2.
[Graphical view]
PANTHERiPTHR15351. PTHR15351. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiERLN2_BOVIN
AccessioniPrimary (citable) accession number: Q1RMU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 16, 2006
Last modified: June 8, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.