Reviewed,
UniProtKB/Swiss-Prot Q1RMU3 (P4HA1_BOVIN)
Last modified
February 9, 2010.
Version 35.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Prolyl 4-hydroxylase subunit alpha-1 Short name=4-PH alpha-1 EC=1.14.11.2 Alternative name(s): Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1 | ||
| Gene names |
| ||
| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 534 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins By similarity. |
| Catalytic activity | L-proline-[procollagen] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-proline-[procollagen] + succinate + CO2. |
| Cofactor | Binds 1 Fe2+ ion per subunit By similarity. Ascorbate By similarity. |
| Subunit structure | Heterotetramer of two alpha-1 chains and two beta chains (the beta chain is the multi-functional PDI) By similarity. |
| Subcellular location | Endoplasmic reticulum lumen By similarity. |
| Sequence similarities | Belongs to the P4HA family. Contains 1 Fe2OG dioxygenase domain. Contains 1 TPR repeat. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum |
| Domain | Signal TPR repeat |
| Ligand | Iron Metal-binding Vitamin C |
| Molecular function | Dioxygenase Oxidoreductase |
| PTM | Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | L-ascorbic acid binding Inferred from electronic annotation. Source: UniProtKB-KW iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenInferred from electronic annotation. Source: UniProtKB-KW procollagen-proline 4-dioxygenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 17 | 17 | By similarity | ||||||
| Chain | 18 – 534 | 517 | Prolyl 4-hydroxylase subunit alpha-1 | PRO_0000288111 | |||||
Regions | |||||||||
| Repeat | 205 – 238 | 34 | TPR | ||||||
| Domain | 411 – 519 | 109 | Fe2OG dioxygenase | ||||||
Sites | |||||||||
| Metal binding | 429 | 1 | Iron By similarity | ||||||
| Metal binding | 431 | 1 | Iron By similarity | ||||||
| Metal binding | 500 | 1 | Iron By similarity | ||||||
| Binding site | 510 | 1 | 2-oxoglutarate Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 113 | 1 | N-linked (GlcNAc...) | ||||||
| Glycosylation | 259 | 1 | N-linked (GlcNAc...) | ||||||
Sequences
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References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Uterus. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC114708 mRNA. Translation: AAI14709.1. |
| IPI | IPI00700678. |
| RefSeq | NP_001069238.1. |
| UniGene | Bt.41027 |
3D structure databases | |
| SMR | Q1RMU3. Positions 161-254, 334-521. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 518288. |
| KEGG | bta:518288. |
Organism-specific databases | |
| CTD | 518288. |
Phylogenomic databases | |
| HOVERGEN | Q1RMU3. |
Enzyme and pathway databases | |
| BRENDA | 1.14.11.2. 251. |
Family and domain databases | |
| InterPro | IPR005123. Oxoglutarate/Fe-dep_oxygenase. IPR006620. Pro_4_hyd_alph. IPR013547. Pro_4_hyd_alph_N. IPR013026. TPR-contain. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view] |
| Gene3D | G3DSA:1.25.40.10. TPR-like_helical. 1 hit. |
| Pfam | PF03171. 2OG-FeII_Oxy. 1 hit. PF08336. P4Ha_N. 1 hit. [Graphical view] |
| SMART | SM00702. P4Hc. 1 hit. [Graphical view] |
| PROSITE | PS51471. FE2OG_OXY. 1 hit. PS50005. TPR. 1 hit. PS50293. TPR_REGION. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | P4HA1_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q1RMU3 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


