Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase RIO3

Gene

RIOK3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 within the C-terminal region interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei290ATPBy similarity1
Active sitei406Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi257 – 265ATPBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processAntiviral defense, Immunity, Innate immunity, Ribosome biogenesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase RIO3 (EC:2.7.11.1)
Alternative name(s):
RIO kinase 3
Gene namesi
Name:RIOK3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 24

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002478071 – 519Serine/threonine-protein kinase RIO3Add BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1
Modified residuei112PhosphoserineBy similarity1
Modified residuei122PhosphotyrosineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei127PhosphoserineBy similarity1
Modified residuei128PhosphoserineBy similarity1

Post-translational modificationi

Autophosphorylated (in vitro).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ1RMT7.
PRIDEiQ1RMT7.

Expressioni

Gene expression databases

BgeeiENSBTAG00000010042.

Interactioni

Subunit structurei

Interacts with CASP10. Interacts with IRF3; RIOK3 probybly mediates the interaction of TBK1 with IRF3. Associated with 40S pre-ribosomal particles.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013242.

Structurei

3D structure databases

ProteinModelPortaliQ1RMT7.
SMRiQ1RMT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini251 – 519Protein kinaseAdd BLAST269

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2269. Eukaryota.
COG1718. LUCA.
GeneTreeiENSGT00390000004370.
HOGENOMiHOG000007623.
HOVERGENiHBG057475.
InParanoidiQ1RMT7.
KOiK08872.
OMAiKMNEDHV.
OrthoDBiEOG091G064C.
TreeFamiTF105831.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR017406. Ser/Thr_kinase_Rio3.
PANTHERiPTHR10593:SF75. PTHR10593:SF75. 1 hit.
PIRSFiPIRSF038146. Ser/Thr_PK_RIO3. 1 hit.
SMARTiView protein in SMART
SM00090. RIO. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS01245. RIO1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RMT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVRVASPE PGPAAAWGPN KCPWATPQNT ISCSLSDVMS EQLAKELQLE
60 70 80 90 100
EEAAAFPEVT VAEGPFITGE NIDTSSDLML AQMLQMEFDR EYDAQLRREE
110 120 130 140 150
KKFNGDSKVC ISFENYRKVH PYEDSDSSED EVDWQDTRDD PYRPAKPIPT
160 170 180 190 200
PKKGFIGKGK DITTKHDEVV CGRKNTARME NFAPGFQVGD GIGMDLKLSN
210 220 230 240 250
HVFNALKQHA YSEERRSARL HEKKEHSTAE KAVDPKTRLL MYKMVNSGML
260 270 280 290 300
ETITGCISTG KESVVFHAYG GSMEDGKEDS KVIPTECAIK VFKTTLNEFK
310 320 330 340 350
NRDKYIKDDF RFKDRFSKLN PRKIIRMWAE KEMHNLTRMQ RAGIPCPTVV
360 370 380 390 400
LLKKHILVMS FIGHDQVPAP KLKEVKLSSE EMKDAYYQTL HLMQQLYDEC
410 420 430 440 450
TLVHADLSEY NMLWHAGKVW LIDVSQSVEP THPHGLEFLF RDCRNVSQFF
460 470 480 490 500
QKGGVKEALG ERELFNAVSG LNISADNEAD FLAEIEALEK MNEDHVQKNG
510
RKAASFLKDD GGPPILYDE
Length:519
Mass (Da):58,928
Last modified:May 16, 2006 - v1
Checksum:i8DB7217FD5FE4740
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114721 mRNA. Translation: AAI14722.1.
RefSeqiNP_001069304.1. NM_001075836.1.
UniGeneiBt.52758.

Genome annotation databases

EnsembliENSBTAT00000013242; ENSBTAP00000013242; ENSBTAG00000010042.
GeneIDi522917.
KEGGibta:522917.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRIOK3_BOVIN
AccessioniPrimary (citable) accession number: Q1RMT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 16, 2006
Last modified: June 7, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families