Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase RIO3

Gene

RIOK3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 within the C-terminal region interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei290ATPBy similarity1
Active sitei406Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi257 – 265ATPBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processAntiviral defense, Immunity, Innate immunity, Ribosome biogenesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase RIO3 (EC:2.7.11.1)
Alternative name(s):
RIO kinase 3
Gene namesi
Name:RIOK3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 24

Organism-specific databases

VGNCiVGNC:49977 RIOK3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002478071 – 519Serine/threonine-protein kinase RIO3Add BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1
Modified residuei112PhosphoserineBy similarity1
Modified residuei122PhosphotyrosineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei127PhosphoserineBy similarity1
Modified residuei128PhosphoserineBy similarity1

Post-translational modificationi

Autophosphorylated (in vitro).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ1RMT7
PRIDEiQ1RMT7

Expressioni

Gene expression databases

BgeeiENSBTAG00000010042

Interactioni

Subunit structurei

Interacts with CASP10. Interacts with IRF3; RIOK3 probybly mediates the interaction of TBK1 with IRF3. Associated with 40S pre-ribosomal particles.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013242

Structurei

3D structure databases

ProteinModelPortaliQ1RMT7
SMRiQ1RMT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini251 – 519Protein kinaseAdd BLAST269

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2269 Eukaryota
COG1718 LUCA
GeneTreeiENSGT00390000004370
HOGENOMiHOG000007623
HOVERGENiHBG057475
InParanoidiQ1RMT7
KOiK08872
OMAiKMNEDHV
OrthoDBiEOG091G064C
TreeFamiTF105831

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000687 RIO_kinase
IPR018935 RIO_kinase_CS
IPR017406 Ser/Thr_kinase_Rio3
PIRSFiPIRSF038146 Ser/Thr_PK_RIO3, 1 hit
SMARTiView protein in SMART
SM00090 RIO, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01245 RIO1, 1 hit

Sequencei

Sequence statusi: Complete.

Q1RMT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVRVASPE PGPAAAWGPN KCPWATPQNT ISCSLSDVMS EQLAKELQLE
60 70 80 90 100
EEAAAFPEVT VAEGPFITGE NIDTSSDLML AQMLQMEFDR EYDAQLRREE
110 120 130 140 150
KKFNGDSKVC ISFENYRKVH PYEDSDSSED EVDWQDTRDD PYRPAKPIPT
160 170 180 190 200
PKKGFIGKGK DITTKHDEVV CGRKNTARME NFAPGFQVGD GIGMDLKLSN
210 220 230 240 250
HVFNALKQHA YSEERRSARL HEKKEHSTAE KAVDPKTRLL MYKMVNSGML
260 270 280 290 300
ETITGCISTG KESVVFHAYG GSMEDGKEDS KVIPTECAIK VFKTTLNEFK
310 320 330 340 350
NRDKYIKDDF RFKDRFSKLN PRKIIRMWAE KEMHNLTRMQ RAGIPCPTVV
360 370 380 390 400
LLKKHILVMS FIGHDQVPAP KLKEVKLSSE EMKDAYYQTL HLMQQLYDEC
410 420 430 440 450
TLVHADLSEY NMLWHAGKVW LIDVSQSVEP THPHGLEFLF RDCRNVSQFF
460 470 480 490 500
QKGGVKEALG ERELFNAVSG LNISADNEAD FLAEIEALEK MNEDHVQKNG
510
RKAASFLKDD GGPPILYDE
Length:519
Mass (Da):58,928
Last modified:May 16, 2006 - v1
Checksum:i8DB7217FD5FE4740
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114721 mRNA Translation: AAI14722.1
RefSeqiNP_001069304.1, NM_001075836.1
UniGeneiBt.52758

Genome annotation databases

EnsembliENSBTAT00000013242; ENSBTAP00000013242; ENSBTAG00000010042
GeneIDi522917
KEGGibta:522917

Similar proteinsi

Entry informationi

Entry nameiRIOK3_BOVIN
AccessioniPrimary (citable) accession number: Q1RMT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 16, 2006
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health