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Protein

Serine/threonine-protein kinase RIO3

Gene

RIOK3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei290 – 2901ATPBy similarity
Active sitei406 – 4061Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi257 – 2659ATPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase RIO3 (EC:2.7.11.1)
Alternative name(s):
RIO kinase 3
Gene namesi
Name:RIOK3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 24

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Serine/threonine-protein kinase RIO3PRO_0000247807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei122 – 1221PhosphotyrosineBy similarity
Modified residuei125 – 1251PhosphoserineBy similarity
Modified residuei127 – 1271PhosphoserineBy similarity
Modified residuei128 – 1281PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ1RMT7.
PRIDEiQ1RMT7.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013242.

Structurei

3D structure databases

ProteinModelPortaliQ1RMT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini251 – 519269Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Phylogenomic databases

eggNOGiKOG2269. Eukaryota.
COG1718. LUCA.
GeneTreeiENSGT00390000004370.
HOGENOMiHOG000007623.
HOVERGENiHBG057475.
InParanoidiQ1RMT7.
KOiK08872.
OMAiLPKECAI.
OrthoDBiEOG7JT6W1.
TreeFamiTF105831.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR017406. Ser/Thr_kinase_Rio3.
[Graphical view]
PANTHERiPTHR10593:SF22. PTHR10593:SF22. 1 hit.
PIRSFiPIRSF038146. Ser/Thr_PK_RIO3. 1 hit.
SMARTiSM00090. RIO. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01245. RIO1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RMT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVRVASPE PGPAAAWGPN KCPWATPQNT ISCSLSDVMS EQLAKELQLE
60 70 80 90 100
EEAAAFPEVT VAEGPFITGE NIDTSSDLML AQMLQMEFDR EYDAQLRREE
110 120 130 140 150
KKFNGDSKVC ISFENYRKVH PYEDSDSSED EVDWQDTRDD PYRPAKPIPT
160 170 180 190 200
PKKGFIGKGK DITTKHDEVV CGRKNTARME NFAPGFQVGD GIGMDLKLSN
210 220 230 240 250
HVFNALKQHA YSEERRSARL HEKKEHSTAE KAVDPKTRLL MYKMVNSGML
260 270 280 290 300
ETITGCISTG KESVVFHAYG GSMEDGKEDS KVIPTECAIK VFKTTLNEFK
310 320 330 340 350
NRDKYIKDDF RFKDRFSKLN PRKIIRMWAE KEMHNLTRMQ RAGIPCPTVV
360 370 380 390 400
LLKKHILVMS FIGHDQVPAP KLKEVKLSSE EMKDAYYQTL HLMQQLYDEC
410 420 430 440 450
TLVHADLSEY NMLWHAGKVW LIDVSQSVEP THPHGLEFLF RDCRNVSQFF
460 470 480 490 500
QKGGVKEALG ERELFNAVSG LNISADNEAD FLAEIEALEK MNEDHVQKNG
510
RKAASFLKDD GGPPILYDE
Length:519
Mass (Da):58,928
Last modified:May 16, 2006 - v1
Checksum:i8DB7217FD5FE4740
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114721 mRNA. Translation: AAI14722.1.
RefSeqiNP_001069304.1. NM_001075836.1.
UniGeneiBt.52758.

Genome annotation databases

EnsembliENSBTAT00000013242; ENSBTAP00000013242; ENSBTAG00000010042.
GeneIDi522917.
KEGGibta:522917.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114721 mRNA. Translation: AAI14722.1.
RefSeqiNP_001069304.1. NM_001075836.1.
UniGeneiBt.52758.

3D structure databases

ProteinModelPortaliQ1RMT7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013242.

Proteomic databases

PaxDbiQ1RMT7.
PRIDEiQ1RMT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013242; ENSBTAP00000013242; ENSBTAG00000010042.
GeneIDi522917.
KEGGibta:522917.

Organism-specific databases

CTDi8780.

Phylogenomic databases

eggNOGiKOG2269. Eukaryota.
COG1718. LUCA.
GeneTreeiENSGT00390000004370.
HOGENOMiHOG000007623.
HOVERGENiHBG057475.
InParanoidiQ1RMT7.
KOiK08872.
OMAiLPKECAI.
OrthoDBiEOG7JT6W1.
TreeFamiTF105831.

Enzyme and pathway databases

ReactomeiR-BTA-6791226. Major pathway of rRNA processing in the nucleolus.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR017406. Ser/Thr_kinase_Rio3.
[Graphical view]
PANTHERiPTHR10593:SF22. PTHR10593:SF22. 1 hit.
PIRSFiPIRSF038146. Ser/Thr_PK_RIO3. 1 hit.
SMARTiSM00090. RIO. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01245. RIO1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiRIOK3_BOVIN
AccessioniPrimary (citable) accession number: Q1RMT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 16, 2006
Last modified: June 8, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.