ID   PYRG2_BOVIN             Reviewed;         586 AA.
AC   Q1RMS2; A5D9B0;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 28.
DE   RecName: Full=CTP synthase 2;
DE            EC=6.3.4.2;
DE   AltName: Full=UTP--ammonia ligase 2;
DE   AltName: Full=CTP synthetase 2;
GN   Name=CTPS2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the ATP-dependent amination of UTP to CTP with
CC       either L-glutamine or ammonia as the source of nitrogen.
CC       Constitutes the rate-limiting enzyme in the synthesis of cytosine
CC       nucleotides (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + UTP + NH(3) = ADP + phosphate + CTP.
CC   -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via de novo
CC       pathway; CTP from UDP: step 2/2.
CC   -!- SIMILARITY: Belongs to the CTP synthase family.
CC   -!- SIMILARITY: Contains 1 glutamine amidotransferase type-1 domain.
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DR   EMBL; BT030529; ABQ12969.1; -; mRNA.
DR   EMBL; BC114742; AAI14743.1; -; mRNA.
DR   IPI; IPI00687870; -.
DR   RefSeq; NP_001070434.1; -.
DR   UniGene; Bt.74451; -.
DR   Ensembl; ENSBTAG00000017017; Bos taurus.
DR   GeneID; 767849; -.
DR   KEGG; bta:767849; -.
DR   HOVERGEN; Q1RMS2; -.
DR   OMA; Q1RMS2; KVPVDGN.
DR   BRENDA; 6.3.4.2; 251.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003883; F:CTP synthase activity; IEA:EC.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR004468; CTP_synthase.
DR   InterPro; IPR017456; CTP_synthase_N.
DR   InterPro; IPR017926; GATASE_1.
DR   InterPro; IPR000991; GATase_class1_C.
DR   PANTHER; PTHR11550; PyrG_synth; 1.
DR   Pfam; PF06418; CTP_synth_N; 1.
DR   Pfam; PF00117; GATase; 1.
DR   TIGRFAMs; TIGR00337; PyrG; 1.
DR   PROSITE; PS51273; GATASE_TYPE_1; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Glutamine amidotransferase; Ligase; Nucleotide-binding;
KW   Phosphoprotein; Pyrimidine biosynthesis.
FT   CHAIN         1    586       CTP synthase 2.
FT                                /FTId=PRO_0000247032.
FT   DOMAIN      300    554       Glutamine amidotransferase type-1.
FT   ACT_SITE    399    399       For GATase activity (By similarity).
FT   ACT_SITE    526    526       For GATase activity (By similarity).
FT   ACT_SITE    528    528       For GATase activity (By similarity).
FT   MOD_RES     568    568       Phosphoserine (By similarity).
FT   MOD_RES     571    571       Phosphoserine (By similarity).
FT   MOD_RES     574    574       Phosphoserine (By similarity).
SQ   SEQUENCE   586 AA;  65481 MW;  0A6E65BF35958831 CRC64;
     MKYILVTGGV ISGIGKGIIA SSIGTILKSC GLRVTAIKID PYINIDAGTF SPYEHGEVFV
     LNDGGEVDLD LGNYERFLDI NLYKDNNITT GKIYQHVINK ERRGDYLGKT VQVVPHITDA
     VQEWVMNQAM VPVDGHKEEP QICVIELGGT IGDIEGMPFV EAFRQFQFKA KRENFCNIHV
     SLVPQPSATG EQKTKPTQNS VRALRGLGLS PDLIVCRSST PIEMAVKEKI SMFCHVNPEQ
     VICIHDVSST YRVPVLLEEQ GIIKYFKERL DLPIGDSASS LLSKWRNMAD RYERLQKTCS
     IALVGKYTKL RDCYASVFKA LEHSALAINH KLNLMYIDSI DLEQTTEVED PVKFHEAWQK
     LCKADGVLVP GGFGIRGTLG KLQAISWARS RKIPFLGVCL GMQLAVIEFA RNCLNLKDAD
     STEFEPNARV PVVIDMPEHN PGNLGGTMRL GIRRTVFKTE NSILRKLYGD VPFIEERHRH
     RYEVNPSLIS QLEQKDLSFV GQDVDGERME IIELANHPYF VGVQFHPEFS SRPMKPSPPY
     LGLLLAATGN LNAYLLQGCK LSSSDRYSDA SDDSFSEPRL AELEIS
//