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Protein

Angiopoietin-related protein 1

Gene

ANGPTL1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 1
Alternative name(s):
Angiopoietin-like protein 1
Gene namesi
Name:ANGPTL1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 491468Angiopoietin-related protein 1PRO_0000278837Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence analysis
Disulfide bondi280 ↔ 309PROSITE-ProRule annotation
Disulfide bondi432 ↔ 445PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ1RMR1.
PRIDEiQ1RMR1.

Expressioni

Gene expression databases

BgeeiENSBTAG00000010719.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014193.

Structurei

3D structure databases

ProteinModelPortaliQ1RMR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini271 – 491221Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili80 – 16889Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037129.
HOVERGENiHBG103336.
InParanoidiQ1RMR1.
OMAiNEGPFKD.
OrthoDBiEOG091G03M1.
TreeFamiTF336658.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1RMR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAFIWTLSV LFFLLMGIGH GRGRQFKIKK ITQRRYPRAT DGKEDAKKCS
60 70 80 90 100
YTFLVPEQKI TGPICVNTKG QDAGTIKDMI TRMDLENLKD VLSKQKREID
110 120 130 140 150
VLQLVVDVDG NIVNEVKLLR KESRNMNSRV TQLYMQLLHE IIRKRDNSLE
160 170 180 190 200
LSQLENKILN VTTEMLKMAT RYRELEVKYA SLTDLVNNQS VMITLLEEQC
210 220 230 240 250
LRIFSRQDPH VSPPLVQVVP QHIPNSHQYT PGLLGGNEIQ RDPGYPRDLM
260 270 280 290 300
PPPDLVTSPT KSPLKIPPVT FINEGPYKDC QHAKDAGHSV SGIYMIKPEN
310 320 330 340 350
SNGPMQLWCE NSLDPGGWTV IQKRTDGSVN FFRNWENYKK GFGNIDGEYW
360 370 380 390 400
LGLENIYLLS NQDNYKLLIE LEDWSDKKVY AEYSSFRLEP ESEFYRLRLG
410 420 430 440 450
TYQGNAGDSM MWHNGKQFTT LDRDKDMYAG NCAHFHKGGW WYNACAHSNL
460 470 480 490
NGVWYRGGHY RSKYQDGIFW AEYRGGSYSL RAVQMLIKPI D
Length:491
Mass (Da):56,674
Last modified:May 16, 2006 - v1
Checksum:i5275247C15D3FB2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU599224 mRNA. Translation: ACD50900.1.
EU599231 Genomic DNA. Translation: ACD50907.1.
BC114763 mRNA. Translation: AAI14764.1.
RefSeqiNP_001068894.1. NM_001075426.1.
XP_015330623.1. XM_015475137.1.
UniGeneiBt.16731.

Genome annotation databases

EnsembliENSBTAT00000014193; ENSBTAP00000014193; ENSBTAG00000010719.
GeneIDi509971.
KEGGibta:509971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU599224 mRNA. Translation: ACD50900.1.
EU599231 Genomic DNA. Translation: ACD50907.1.
BC114763 mRNA. Translation: AAI14764.1.
RefSeqiNP_001068894.1. NM_001075426.1.
XP_015330623.1. XM_015475137.1.
UniGeneiBt.16731.

3D structure databases

ProteinModelPortaliQ1RMR1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014193.

Proteomic databases

PaxDbiQ1RMR1.
PRIDEiQ1RMR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014193; ENSBTAP00000014193; ENSBTAG00000010719.
GeneIDi509971.
KEGGibta:509971.

Organism-specific databases

CTDi9068.

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037129.
HOVERGENiHBG103336.
InParanoidiQ1RMR1.
OMAiNEGPFKD.
OrthoDBiEOG091G03M1.
TreeFamiTF336658.

Gene expression databases

BgeeiENSBTAG00000010719.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANGL1_BOVIN
AccessioniPrimary (citable) accession number: Q1RMR1
Secondary accession number(s): B2Z4A9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: May 16, 2006
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.