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Q1RMJ6

- RHOC_BOVIN

UniProt

Q1RMJ6 - RHOC_BOVIN

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Protein

Rho-related GTP-binding protein RhoC

Gene

RHOC

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 198GTPBy similarity
Nucleotide bindingi59 – 635GTPBy similarity
Nucleotide bindingi117 – 1204GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. signal transducer activity Source: Ensembl

GO - Biological processi

  1. apical junction assembly Source: UniProtKB
  2. cytokinesis Source: UniProtKB
  3. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  4. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_205384. G alpha (12/13) signalling events.
REACT_211150. Rho GTPase cycle.
REACT_218808. Sema4D induced cell migration and growth-cone collapse.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoC
Gene namesi
Name:RHOC
Synonyms:ARHC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 3

Subcellular locationi

Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Cleavage furrow By similarity
Note: Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.By similarity

GO - Cellular componenti

  1. cleavage furrow Source: UniProtKB
  2. extracellular vesicular exosome Source: Ensembl
  3. nucleus Source: Ensembl
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Rho-related GTP-binding protein RhoCPRO_0000265728Add
BLAST
Propeptidei191 – 1933Removed in mature formBy similarityPRO_0000265729

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei190 – 1901Cysteine methyl esterBy similarity
Lipidationi190 – 1901S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ1RMJ6.
PRIDEiQ1RMJ6.

Interactioni

Subunit structurei

Interacts with AKAP13, DIAPH1, RTKN, PKN2, ROCK1 and ROCK2. Interacts with RTKN. Interacts with ARHGDIA.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018998.

Structurei

3D structure databases

ProteinModelPortaliQ1RMJ6.
SMRiQ1RMJ6. Positions 3-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi34 – 429Effector regionSequence Analysis

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiQ1RMJ6.
KOiK07857.
OMAiGKKHHCV.
OrthoDBiEOG73FQPD.
TreeFamiTF300837.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1RMJ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG
60 70 80 90 100
KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT
110 120 130 140 150
PEVKHFCPNV PIILVGNKKD LRQDEHTRRE LAKMKQEPVR SEEGRDMANR
160 170 180 190
ISAFGYLECS AKTKEGVREV FEMATRAGLQ VRKNKRRRGC PIL
Length:193
Mass (Da):22,006
Last modified:May 16, 2006 - v1
Checksum:iA193DA581560F131
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114859 mRNA. Translation: AAI14860.1.
RefSeqiNP_001039603.1. NM_001046138.2.
XP_005204165.1. XM_005204108.1.
XP_005204166.1. XM_005204109.1.
UniGeneiBt.22455.

Genome annotation databases

EnsembliENSBTAT00000018998; ENSBTAP00000018998; ENSBTAG00000014299.
GeneIDi513152.
KEGGibta:513152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114859 mRNA. Translation: AAI14860.1 .
RefSeqi NP_001039603.1. NM_001046138.2.
XP_005204165.1. XM_005204108.1.
XP_005204166.1. XM_005204109.1.
UniGenei Bt.22455.

3D structure databases

ProteinModelPortali Q1RMJ6.
SMRi Q1RMJ6. Positions 3-179.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000018998.

Proteomic databases

PaxDbi Q1RMJ6.
PRIDEi Q1RMJ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000018998 ; ENSBTAP00000018998 ; ENSBTAG00000014299 .
GeneIDi 513152.
KEGGi bta:513152.

Organism-specific databases

CTDi 389.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000119020.
HOGENOMi HOG000233974.
HOVERGENi HBG009351.
InParanoidi Q1RMJ6.
KOi K07857.
OMAi GKKHHCV.
OrthoDBi EOG73FQPD.
TreeFami TF300837.

Enzyme and pathway databases

Reactomei REACT_205384. G alpha (12/13) signalling events.
REACT_211150. Rho GTPase cycle.
REACT_218808. Sema4D induced cell migration and growth-cone collapse.

Miscellaneous databases

NextBioi 20870726.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00174. RHO. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51420. RHO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.

Entry informationi

Entry nameiRHOC_BOVIN
AccessioniPrimary (citable) accession number: Q1RMJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 16, 2006
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3