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Q1RMJ6 (RHOC_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rho-related GTP-binding protein RhoC
Gene names
Name:RHOC
Synonyms:ARHC
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells By similarity.

Subunit structure

Interacts with AKAP13, DIAPH1, RTKN, PKN2, ROCK1 and ROCK2 By similarity. Interacts with RTKN By similarity. Interacts with ARHGDIA By similarity.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity. Cleavage furrow By similarity. Note: Translocates to the equatorial region before furrow formation in a ECT2-dependent manner By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Rho family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 190190Rho-related GTP-binding protein RhoC
PRO_0000265728
Propeptide191 – 1933Removed in mature form By similarity
PRO_0000265729

Regions

Nucleotide binding12 – 198GTP By similarity
Nucleotide binding59 – 635GTP By similarity
Nucleotide binding117 – 1204GTP By similarity
Motif34 – 429Effector region Potential

Amino acid modifications

Modified residue1901Cysteine methyl ester By similarity
Lipidation1901S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RMJ6 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: A193DA581560F131

FASTA19322,006
        10         20         30         40         50         60 
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG KQVELALWDT 

        70         80         90        100        110        120 
AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD 

       130        140        150        160        170        180 
LRQDEHTRRE LAKMKQEPVR SEEGRDMANR ISAFGYLECS AKTKEGVREV FEMATRAGLQ 

       190 
VRKNKRRRGC PIL 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Heart ventricle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC114859 mRNA. Translation: AAI14860.1.
RefSeqNP_001039603.1. NM_001046138.2.
XP_005204165.1. XM_005204108.1.
XP_005204166.1. XM_005204109.1.
UniGeneBt.22455.

3D structure databases

ProteinModelPortalQ1RMJ6.
SMRQ1RMJ6. Positions 3-179.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000018998.

Proteomic databases

PaxDbQ1RMJ6.
PRIDEQ1RMJ6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000018998; ENSBTAP00000018998; ENSBTAG00000014299.
GeneID513152.
KEGGbta:513152.

Organism-specific databases

CTD389.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00700000104143.
HOGENOMHOG000233974.
HOVERGENHBG009351.
InParanoidQ1RMJ6.
KOK07857.
OMAGKKHHCV.
OrthoDBEOG73FQPD.
TreeFamTF300837.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20870726.

Entry information

Entry nameRHOC_BOVIN
AccessionPrimary (citable) accession number: Q1RMJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families