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Q1RMJ6

- RHOC_BOVIN

UniProt

Q1RMJ6 - RHOC_BOVIN

Protein

Rho-related GTP-binding protein RhoC

Gene

RHOC

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 198GTPBy similarity
    Nucleotide bindingi59 – 635GTPBy similarity
    Nucleotide bindingi117 – 1204GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. signal transducer activity Source: Ensembl

    GO - Biological processi

    1. apical junction assembly Source: UniProtKB
    2. cytokinesis Source: UniProtKB
    3. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    4. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_205384. G alpha (12/13) signalling events.
    REACT_211150. Rho GTPase cycle.
    REACT_218808. Sema4D induced cell migration and growth-cone collapse.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho-related GTP-binding protein RhoC
    Gene namesi
    Name:RHOC
    Synonyms:ARHC
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 3

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Cleavage furrow By similarity
    Note: Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.By similarity

    GO - Cellular componenti

    1. cleavage furrow Source: UniProtKB
    2. nucleus Source: Ensembl
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 190190Rho-related GTP-binding protein RhoCPRO_0000265728Add
    BLAST
    Propeptidei191 – 1933Removed in mature formBy similarityPRO_0000265729

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei190 – 1901Cysteine methyl esterBy similarity
    Lipidationi190 – 1901S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiQ1RMJ6.
    PRIDEiQ1RMJ6.

    Interactioni

    Subunit structurei

    Interacts with AKAP13, DIAPH1, RTKN, PKN2, ROCK1 and ROCK2. Interacts with RTKN. Interacts with ARHGDIA.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000018998.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RMJ6.
    SMRiQ1RMJ6. Positions 3-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi34 – 429Effector regionSequence Analysis

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rho family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00700000104143.
    HOGENOMiHOG000233974.
    HOVERGENiHBG009351.
    InParanoidiQ1RMJ6.
    KOiK07857.
    OMAiGKKHHCV.
    OrthoDBiEOG73FQPD.
    TreeFamiTF300837.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00174. RHO. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51420. RHO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q1RMJ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG    50
    KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT 100
    PEVKHFCPNV PIILVGNKKD LRQDEHTRRE LAKMKQEPVR SEEGRDMANR 150
    ISAFGYLECS AKTKEGVREV FEMATRAGLQ VRKNKRRRGC PIL 193
    Length:193
    Mass (Da):22,006
    Last modified:May 16, 2006 - v1
    Checksum:iA193DA581560F131
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC114859 mRNA. Translation: AAI14860.1.
    RefSeqiNP_001039603.1. NM_001046138.2.
    XP_005204165.1. XM_005204108.1.
    XP_005204166.1. XM_005204109.1.
    UniGeneiBt.22455.

    Genome annotation databases

    EnsembliENSBTAT00000018998; ENSBTAP00000018998; ENSBTAG00000014299.
    GeneIDi513152.
    KEGGibta:513152.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC114859 mRNA. Translation: AAI14860.1 .
    RefSeqi NP_001039603.1. NM_001046138.2.
    XP_005204165.1. XM_005204108.1.
    XP_005204166.1. XM_005204109.1.
    UniGenei Bt.22455.

    3D structure databases

    ProteinModelPortali Q1RMJ6.
    SMRi Q1RMJ6. Positions 3-179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000018998.

    Proteomic databases

    PaxDbi Q1RMJ6.
    PRIDEi Q1RMJ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000018998 ; ENSBTAP00000018998 ; ENSBTAG00000014299 .
    GeneIDi 513152.
    KEGGi bta:513152.

    Organism-specific databases

    CTDi 389.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00700000104143.
    HOGENOMi HOG000233974.
    HOVERGENi HBG009351.
    InParanoidi Q1RMJ6.
    KOi K07857.
    OMAi GKKHHCV.
    OrthoDBi EOG73FQPD.
    TreeFami TF300837.

    Enzyme and pathway databases

    Reactomei REACT_205384. G alpha (12/13) signalling events.
    REACT_211150. Rho GTPase cycle.
    REACT_218808. Sema4D induced cell migration and growth-cone collapse.

    Miscellaneous databases

    NextBioi 20870726.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00174. RHO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51420. RHO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Heart ventricle.

    Entry informationi

    Entry nameiRHOC_BOVIN
    AccessioniPrimary (citable) accession number: Q1RMJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3