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Protein
Submitted name:

ROBO1 protein

Gene

ROBO1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ROBO1 proteinImported
Gene namesi
Name:ROBO1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34620.

PTM / Processingi

Proteomic databases

PaxDbiQ1RMC8.
PeptideAtlasiQ1RMC8.
PRIDEiQ1RMC8.

Expressioni

Gene expression databases

GenevisibleiQ1RMC8. HS.

Interactioni

Protein-protein interaction databases

IntActiQ1RMC8. 1 interactor.
STRINGi9606.ENSP00000420321.

Structurei

3D structure databases

ProteinModelPortaliQ1RMC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 125Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST97
Domaini131 – 218Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST88
Domaini223 – 307Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST85
Domaini315 – 410Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST96
Domaini419 – 505Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST87
Domaini527 – 621Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini640 – 737Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini742 – 838Fibronectin type-IIIInterPro annotationAdd BLAST97

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG4222. Eukaryota.
ENOG410XPQS. LUCA.
HOVERGENiHBG073476.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 9 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR032986. Robo1.
[Graphical view]
PANTHERiPTHR10489:SF107. PTHR10489:SF107. 3 hits.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RMC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAEPAHFYL FGLICLCSGS RLRQEDFPPR IVEHPSDLIV SKGEPATLNC
60 70 80 90 100
KAEGRPTPTI EWYKGGERVE TDKDDPRSHR MLLPSGSLFF LRIVHGRKSR
110 120 130 140 150
PDEGVYVCVA RNYLGEAVSH NASLEVAILR DDFRQNPSDV MVAVGEPAVM
160 170 180 190 200
ECQPPRGHPE PTISWKKDGS PLDDKDERIT IRGGKLMITY TRKSDAGKYV
210 220 230 240 250
CVGTNMVGER ESEVAELTVL ERPSFVKRPS NLAVTVDDSA EFKCEARGDP
260 270 280 290 300
VPTVRWRKDD GELPKSRYEI RDDHTLKIRK VTAGDMGSYT CVAENMVGKA
310 320 330 340 350
EASATLTVQV GSEPPHFVVK PRDQVVALGR TVTFQCEATG NPQPAIFWRR
360 370 380 390 400
EGSQNLLFSY QPPQSSSRFS VSQTGDLTIT NVQRSDVGYY ICQTLNVAGS
410 420 430 440 450
IITKAYLEVT DVIADRPPPV IRQGPVNQTV AVDGTFVLSC VATGSPVPTI
460 470 480 490 500
LWRKDGVLVS TQDSRIKQLE NGVLQIRYAK LGDTGRYTCI ASTPSGEATW
510 520 530 540 550
SAYIEVQEFG VPVQPPRPTD PNLIPSAPSK PEVTDVSRNT VTLSWQPNLN
560 570 580 590 600
SGATPTSYII EAFSHASGSS WQTVAENVKT ETSAIKGLKP NAIYLFLVRA
610 620 630 640 650
ANAYGISDPS QISDPVKTQD VLPTSQGVDH KQVQRELGNA VLHLHNPTVL
660 670 680 690 700
SPSSIEVHWT VDQQSQYIQG YKILYRPSGA NHGESDWLVF EVRTPAKNSV
710 720 730 740 750
VIPDLRKGVN YEIKARPFFN EFQGADSEIK FAKTLEEAPS APPQGVTVSK
760 770 780 790 800
NDGNGTAILV SWQPPPEDTQ NGMVQEYKVW CLGNETRYHI NKTVDGSTFS
810 820 830 840 850
VVIPFLVPGI RYSVEVAAST GAGSGVKSEP QFIQLDAHGN PVSPEDQVSL
860 870 880 890 900
AQQISDVVKQ PAFIAGIGAA CWIILMVFSI WLYRHRKKRN GLTSTYAGIR
910 920 930 940 950
KVTYQRGGEA VSSGGRPGLL NISEPAAQPW LADTWPNTGN NHNDCSISCC
960 970 980 990 1000
TAGNGNSDSN LTTYSRPADC IANYNNQLDN KQTNLMLPES TVYGDVDLSN
1010 1020 1030 1040 1050
KINEMKTFNS PNLKDGRFVN PSGQPTPYAT TQLIQSNLSN NMNNGSGDSG
1060 1070 1080 1090 1100
EKHWKPLGQQ KQEVAPVQYN IVEQNKLNKD YRANDTVPPT IPYNQSYDQN
1110 1120 1130 1140 1150
TGGSYNSSDR GSSTSGSQGH KKGARTPKVP KQGGMNWADP LPPPPAHPPP
1160 1170 1180 1190 1200
HSNSEEYNIS VDESYDQEMP CPVPPARMYL QQDELEEEED ERGPTPPVRG
1210 1220 1230 1240 1250
AASSPAAVSY SHQSTATLTP SPQEELQPML QDCPEETGHM QHQPDRRRQP
1260 1270 1280 1290 1300
VSPPPPPRPI SPPHTYGYIS GPLVSDMDTD APEEEEDEAD MEVAKMQTRR
1310 1320 1330 1340 1350
LLLRGLEQTP ASSVGDLESS VTGSMINGWG SASEEDNISS GRSSVSSSDG
1360 1370 1380 1390 1400
SFFTDADFAQ AVAAAAEYAG LKVARRQMQD AAGRRHFHAS QCPRPTSPVS
1410 1420 1430 1440 1450
TDSNMSAAVM QKTRPAKKLK HQPGHLRRET YTDDLPPPPV PPPAIKSPTA
1460 1470 1480 1490 1500
QSKTQLEVRP VVVPKLPSMD ARTDRSSDRK GSSYKGREVL DGRQVVDMRT
1510 1520 1530 1540 1550
NPGDPREAQE QQNDGKGRGN KAAKRDLPPA KTHLIQEDIL PYCRPTFPTS
1560 1570 1580 1590 1600
NNPRDPSSSS SMSSRGSGSR QREQANVGRR NIAEMQVLGG YERGEDNNEE

LEETES
Length:1,606
Mass (Da):175,830
Last modified:May 16, 2006 - v1
Checksum:i1A4D020697BA9AD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC115020 mRNA. Translation: AAI15021.1.
RefSeqiNP_598334.2. NM_133631.3.
UniGeneiHs.744218.

Genome annotation databases

GeneIDi6091.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC115020 mRNA. Translation: AAI15021.1.
RefSeqiNP_598334.2. NM_133631.3.
UniGeneiHs.744218.

3D structure databases

ProteinModelPortaliQ1RMC8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ1RMC8. 1 interactor.
STRINGi9606.ENSP00000420321.

Proteomic databases

PaxDbiQ1RMC8.
PeptideAtlasiQ1RMC8.
PRIDEiQ1RMC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6091.

Organism-specific databases

CTDi6091.
PharmGKBiPA34620.

Phylogenomic databases

eggNOGiKOG4222. Eukaryota.
ENOG410XPQS. LUCA.
HOVERGENiHBG073476.

Miscellaneous databases

ChiTaRSiROBO1. human.
GenomeRNAii6091.

Gene expression databases

GenevisibleiQ1RMC8. HS.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 9 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR032986. Robo1.
[Graphical view]
PANTHERiPTHR10489:SF107. PTHR10489:SF107. 3 hits.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ1RMC8_HUMAN
AccessioniPrimary (citable) accession number: Q1RMC8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: November 30, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.