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Q1RLU9

- CDK15_DANRE

UniProt

Q1RLU9 - CDK15_DANRE

Protein

Cyclin-dependent kinase 15

Gene

cdk15

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei113 – 1131ATPPROSITE-ProRule annotation
    Active sitei205 – 2051Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi90 – 989ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 15 (EC:2.7.11.22)
    Alternative name(s):
    Cell division protein kinase 15
    Gene namesi
    Name:cdk15
    Synonyms:pftk2
    ORF Names:zgc:136819
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 6

    Organism-specific databases

    ZFINiZDB-GENE-060421-7193. cdk15.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 418418Cyclin-dependent kinase 15PRO_0000391902Add
    BLAST

    Proteomic databases

    PRIDEiQ1RLU9.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000075572.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RLU9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini84 – 369286Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00600000083998.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiQ1RLU9.
    KOiK15594.
    OMAiRQGIPFG.
    OrthoDBiEOG7966H8.
    PhylomeDBiQ1RLU9.
    TreeFamiTF106508.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1RLU9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQNLRHAASE AFQRLGLKQR HLGYEELGEL DGVEKPQPHW FHTLQVRRLR    50
    VQRGRSNSDP MGGKSFQQEF QWKTGLQFGN ATSYLNLEKL GEGTYATVYK 100
    GISRINGHLV ALKVIHMKTE EGIPFTAIRE ASLLKGLKHA NIVLLHDIIH 150
    TRESLTFVFE YVQTDLAQYM IQHPGGLHSY NIRLFMFQLL RGLSYIHGRR 200
    ILHRDLKPQN LLISYLGELK LADFGLARSK SIPCQTYSAE VVTLWYRPPD 250
    VLMGSTDYST ALDIWGAGCI FIEMLQGSPA FPGVADVFEQ LLKIWTVIGV 300
    PTEEIWPGVS DLPNYKPEWF LPCKPQQFRD VWKRLSQLPY KTEDLAQQML 350
    MMNPKDRISA QDALLHPYFN TLPPPLMHLR DTVSIFKVPG VRLESEARDI 400
    FSPSRRTKTP LAPLAKCW 418
    Length:418
    Mass (Da):47,907
    Last modified:May 16, 2006 - v1
    Checksum:i2C0E4D7011739325
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC115279 mRNA. Translation: AAI15280.1.
    RefSeqiNP_001035398.1. NM_001040308.1.
    XP_005165793.1. XM_005165736.1.
    UniGeneiDr.5454.

    Genome annotation databases

    EnsembliENSDART00000081129; ENSDARP00000075572; ENSDARG00000006093.
    GeneIDi791619.
    KEGGidre:791619.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC115279 mRNA. Translation: AAI15280.1 .
    RefSeqi NP_001035398.1. NM_001040308.1.
    XP_005165793.1. XM_005165736.1.
    UniGenei Dr.5454.

    3D structure databases

    ProteinModelPortali Q1RLU9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000075572.

    Proteomic databases

    PRIDEi Q1RLU9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000081129 ; ENSDARP00000075572 ; ENSDARG00000006093 .
    GeneIDi 791619.
    KEGGi dre:791619.

    Organism-specific databases

    CTDi 65061.
    ZFINi ZDB-GENE-060421-7193. cdk15.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00600000083998.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi Q1RLU9.
    KOi K15594.
    OMAi RQGIPFG.
    OrthoDBi EOG7966H8.
    PhylomeDBi Q1RLU9.
    TreeFami TF106508.

    Miscellaneous databases

    NextBioi 20930704.
    PROi Q1RLU9.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCDK15_DANRE
    AccessioniPrimary (citable) accession number: Q1RLU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 2, 2010
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3