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Q1RLU9 (CDK15_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 15

EC=2.7.11.22
Alternative name(s):
Cell division protein kinase 15
Gene names
Name:cdk15
Synonyms:pftk2
ORF Names:zgc:136819
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 418418Cyclin-dependent kinase 15
PRO_0000391902

Regions

Domain84 – 369286Protein kinase
Nucleotide binding90 – 989ATP By similarity

Sites

Active site2051Proton acceptor By similarity
Binding site1131ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RLU9 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 2C0E4D7011739325

FASTA41847,907
        10         20         30         40         50         60 
MQNLRHAASE AFQRLGLKQR HLGYEELGEL DGVEKPQPHW FHTLQVRRLR VQRGRSNSDP 

        70         80         90        100        110        120 
MGGKSFQQEF QWKTGLQFGN ATSYLNLEKL GEGTYATVYK GISRINGHLV ALKVIHMKTE 

       130        140        150        160        170        180 
EGIPFTAIRE ASLLKGLKHA NIVLLHDIIH TRESLTFVFE YVQTDLAQYM IQHPGGLHSY 

       190        200        210        220        230        240 
NIRLFMFQLL RGLSYIHGRR ILHRDLKPQN LLISYLGELK LADFGLARSK SIPCQTYSAE 

       250        260        270        280        290        300 
VVTLWYRPPD VLMGSTDYST ALDIWGAGCI FIEMLQGSPA FPGVADVFEQ LLKIWTVIGV 

       310        320        330        340        350        360 
PTEEIWPGVS DLPNYKPEWF LPCKPQQFRD VWKRLSQLPY KTEDLAQQML MMNPKDRISA 

       370        380        390        400        410 
QDALLHPYFN TLPPPLMHLR DTVSIFKVPG VRLESEARDI FSPSRRTKTP LAPLAKCW 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC115279 mRNA. Translation: AAI15280.1.
RefSeqNP_001035398.1. NM_001040308.1.
XP_005165793.1. XM_005165736.1.
UniGeneDr.5454.

3D structure databases

ProteinModelPortalQ1RLU9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000075572.

Proteomic databases

PRIDEQ1RLU9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000081129; ENSDARP00000075572; ENSDARG00000006093.
GeneID791619.
KEGGdre:791619.

Organism-specific databases

CTD65061.
ZFINZDB-GENE-060421-7193. cdk15.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00600000083998.
HOGENOMHOG000233024.
HOVERGENHBG014652.
InParanoidQ1RLU9.
KOK15594.
OMAHLKHANI.
OrthoDBEOG7966H8.
PhylomeDBQ1RLU9.
TreeFamTF106508.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20930704.
PROQ1RLU9.

Entry information

Entry nameCDK15_DANRE
AccessionPrimary (citable) accession number: Q1RLU9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: May 16, 2006
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families