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Q1RLU9

- CDK15_DANRE

UniProt

Q1RLU9 - CDK15_DANRE

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Protein

Cyclin-dependent kinase 15

Gene

cdk15

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei113 – 1131ATPPROSITE-ProRule annotation
Active sitei205 – 2051Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi90 – 989ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 15 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 15
Gene namesi
Name:cdk15
Synonyms:pftk2
ORF Names:zgc:136819
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-060421-7193. cdk15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Cyclin-dependent kinase 15PRO_0000391902Add
BLAST

Proteomic databases

PRIDEiQ1RLU9.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000075572.

Structurei

3D structure databases

ProteinModelPortaliQ1RLU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 369286Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00600000083998.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ1RLU9.
KOiK15594.
OMAiRQGIPFG.
OrthoDBiEOG7966H8.
PhylomeDBiQ1RLU9.
TreeFamiTF106508.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RLU9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQNLRHAASE AFQRLGLKQR HLGYEELGEL DGVEKPQPHW FHTLQVRRLR
60 70 80 90 100
VQRGRSNSDP MGGKSFQQEF QWKTGLQFGN ATSYLNLEKL GEGTYATVYK
110 120 130 140 150
GISRINGHLV ALKVIHMKTE EGIPFTAIRE ASLLKGLKHA NIVLLHDIIH
160 170 180 190 200
TRESLTFVFE YVQTDLAQYM IQHPGGLHSY NIRLFMFQLL RGLSYIHGRR
210 220 230 240 250
ILHRDLKPQN LLISYLGELK LADFGLARSK SIPCQTYSAE VVTLWYRPPD
260 270 280 290 300
VLMGSTDYST ALDIWGAGCI FIEMLQGSPA FPGVADVFEQ LLKIWTVIGV
310 320 330 340 350
PTEEIWPGVS DLPNYKPEWF LPCKPQQFRD VWKRLSQLPY KTEDLAQQML
360 370 380 390 400
MMNPKDRISA QDALLHPYFN TLPPPLMHLR DTVSIFKVPG VRLESEARDI
410
FSPSRRTKTP LAPLAKCW
Length:418
Mass (Da):47,907
Last modified:May 16, 2006 - v1
Checksum:i2C0E4D7011739325
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC115279 mRNA. Translation: AAI15280.1.
RefSeqiNP_001035398.1. NM_001040308.1.
XP_005165793.1. XM_005165736.2.
UniGeneiDr.5454.

Genome annotation databases

EnsembliENSDART00000081129; ENSDARP00000075572; ENSDARG00000006093.
GeneIDi791619.
KEGGidre:791619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC115279 mRNA. Translation: AAI15280.1 .
RefSeqi NP_001035398.1. NM_001040308.1.
XP_005165793.1. XM_005165736.2.
UniGenei Dr.5454.

3D structure databases

ProteinModelPortali Q1RLU9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000075572.

Proteomic databases

PRIDEi Q1RLU9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000081129 ; ENSDARP00000075572 ; ENSDARG00000006093 .
GeneIDi 791619.
KEGGi dre:791619.

Organism-specific databases

CTDi 65061.
ZFINi ZDB-GENE-060421-7193. cdk15.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00600000083998.
HOGENOMi HOG000233024.
HOVERGENi HBG014652.
InParanoidi Q1RLU9.
KOi K15594.
OMAi RQGIPFG.
OrthoDBi EOG7966H8.
PhylomeDBi Q1RLU9.
TreeFami TF106508.

Miscellaneous databases

NextBioi 20930704.
PROi Q1RLU9.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCDK15_DANRE
AccessioniPrimary (citable) accession number: Q1RLU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: May 16, 2006
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3