Q1RLT1 (Q1RLT1_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GMP reductase RuleBase RU003929
EC=1.7.1.7 RuleBase RU003929

Gene names

Name:	gmpr2 Ensembl ENSDARP00000081732
ORF Names:	zgc:136869 ZFIN ZDB-GENE-060421-6836

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL AAI15300.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. RuleBase RU003929
Catalytic activity	Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. RuleBase RU003929
Sequence similarities	Belongs to the IMPDH/GMPR family. RuleBase RU003927

Ontologies

Keywords
Ligand	Metal-binding RuleBase RU003929 NADP RuleBase RU003929 Potassium RuleBase RU003929
Molecular function	Oxidoreductase RuleBase RU003927
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	GMP reductase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q1RLT1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: FA7DE01AE2C34AB2	FASTA	348	37,496
	10 20 30 40 50 60 MPRIENDIKL DFKDVLLRPK RSTLKSRSEV DLMRSFTFRN SKGSYRGIPI VAANMDTVGT 70 80 90 100 110 120 FEMALALHQF SLFTAMQKHY GVDDWKEFAA KHPECLESVA VSTGTSEGDF EKLGAIVAAV 130 140 150 160 170 180 PQIRYICVDV ANGYSEHFVN FVKDVRQKFP THTIMAGNVV TGEMVEELIL AGADIIKVGI 190 200 210 220 230 240 GPGSVCTTRK KTGVGYPQLS AVIECADAAH GLGGHIISDG GCTCPGDVSK AFGAGADFVM 250 260 270 280 290 300 LGGMLAGHCE SGGEVIEKNG KKYKLFYGMS SDTAMKKHAG GVAEYRASEG KTVEVPYKGP 310 320 330 340 VDVTLRDVLG GVRSTCTYVG AAKLKELSRR TTFIRVTQQL NTVFGNDN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genomic sequence of Danio rerio." The Danio rerio Sequencing Project at the Sanger Institute Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen Ensembl ENSDARP00000081732.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Tuebingen Ensembl ENSDARP00000081732.
[3]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Whole EMBL AAI15300.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR318603 Genomic DNA. No translation available. BC115299 mRNA. Translation: AAI15300.1.
IPI	IPI00758797.
RefSeq	NP_001035394.1. NM_001040304.1.
UniGene	Dr.36011. Dr.49103.
3D structure databases
ProteinModelPortal	Q1RLT1.
SMR	Q1RLT1. Positions 1-338.
ModBase	Search...
Proteomic databases
PRIDE	Q1RLT1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000087298; ENSDARP00000081732; ENSDARG00000061301.
GeneID	678545.
KEGG	dre:678545.
Organism-specific databases
CTD	51292.
ZFIN	ZDB-GENE-030131-1238. gmpr2. ZDB-GENE-060421-6836. zgc:136869.
Phylogenomic databases
eggNOG	fiNOG11659.
GeneTree	ENSGT00530000062923.
HOGENOM	HBG298985.
HOVERGEN	HBG051744.
InParanoid	Q1RLT1.
OMA	FRNSKQM.
OrthoDB	EOG4FXR7V.
PhylomeDB	Q1RLT1.
Gene expression databases
Bgee	Q1RLT1.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR005993. GMP_reduct1. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00364.
Pfam	PF00478. IMPDH. 1 hit. [Graphical view]
PIRSF	PIRSF000235. GMP_reductase. 1 hit.
TIGRFAMs	TIGR01305. GMP_reduct_1. 1 hit.
PROSITE	PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q1RLT1_DANRE

Accession

Primary (citable) accession number: Q1RLT1

Entry history

Integrated into UniProtKB/TrEMBL:	May 16, 2006
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)