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Protein

Putative pyruvate, phosphate dikinase regulatory protein

Gene

RBE_0001

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.UniRule annotation

Catalytic activityi

ADP + [pyruvate, phosphate dikinase] = AMP + [pyruvate, phosphate dikinase] phosphate.UniRule annotation
[Pyruvate, phosphate dikinase] phosphate + phosphate = [pyruvate, phosphate dikinase] + diphosphate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi149 – 1568ADPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

Nucleotide-binding

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-1-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pyruvate, phosphate dikinase regulatory proteinUniRule annotation (EC:2.7.11.32UniRule annotation, EC:2.7.4.27UniRule annotation)
Short name:
PPDK regulatory proteinUniRule annotation
Gene namesi
Ordered Locus Names:RBE_0001
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Putative pyruvate, phosphate dikinase regulatory proteinPRO_0000277932Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi336407.RBE_0001.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1806.
HOGENOMiHOG000218052.
KOiK09773.
OMAiTSKTPTC.
OrthoDBiEOG6KHG2N.

Family and domain databases

HAMAPiMF_00921. PDRP.
InterProiIPR005177. Kinase-pyrophosphorylase.
IPR026565. PPDK_reg.
[Graphical view]
PfamiPF03618. Kinase-PPPase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RKN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKLIIHLVS DSSVQTAKSA AHSALAQFTS LKPKLYHWPM IRNSELLKEV
60 70 80 90 100
LSKIESKHGI VLYTIADQEL RKTLTKFCYE LKIPCISVIS KIIKEMSVFS
110 120 130 140 150
GIEIEKEQNY NYKFDKTYFD TLNAIDYAIR HDDGQLLNEL QFADIILIGP
160 170 180 190 200
SRTSKTPTSV FLAYNGLKTA NIPYVYNCPF PDFIEKDIDQ LVVGLVINPN
210 220 230 240 250
RLIEIRETRL NLLQINENRN YTDFNIVQKE CLEVKKICEL RNWPVIDVST
260 270
KSIEETAALI MRIYYNKKNK YKK
Length:273
Mass (Da):31,638
Last modified:May 16, 2006 - v1
Checksum:iAC8401E0FF49DB15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04082.1.
RefSeqiWP_011476697.1. NC_007940.1.
YP_537171.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04082; ABE04082; RBE_0001.
KEGGirbe:RBE_0001.
PATRICi17881231. VBIRicBel102610_0001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04082.1.
RefSeqiWP_011476697.1. NC_007940.1.
YP_537171.1. NC_007940.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi336407.RBE_0001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE04082; ABE04082; RBE_0001.
KEGGirbe:RBE_0001.
PATRICi17881231. VBIRicBel102610_0001.

Phylogenomic databases

eggNOGiCOG1806.
HOGENOMiHOG000218052.
KOiK09773.
OMAiTSKTPTC.
OrthoDBiEOG6KHG2N.

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-1-MONOMER.

Family and domain databases

HAMAPiMF_00921. PDRP.
InterProiIPR005177. Kinase-pyrophosphorylase.
IPR026565. PPDK_reg.
[Graphical view]
PfamiPF03618. Kinase-PPPase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiPDRP_RICBR
AccessioniPrimary (citable) accession number: Q1RKN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 16, 2006
Last modified: April 1, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.