Reviewed, UniProtKB/Swiss-Prot Q1RKN1 (THIO_RICBR)

Names and origin

Protein names

Recommended name:
    Thioredoxin
      Short name=Trx

Gene names

Name:	trxA
Ordered Locus Names:	RBE_0002

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	105 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions By similarity.
Sequence similarities	Belongs to the thioredoxin family. Contains 1 thioredoxin domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Domain	Redox-active center
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW glycerol ether metabolic process Inferred from electronic annotation. Source: InterPro transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 105	105	Thioredoxin		PRO_0000272626
Regions
	Domain	1 – 105	105	Thioredoxin
Amino acid modifications
	Disulfide bond	30 ↔ 33		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1RKN1-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 3855E85C86EC2E2A	FASTA	105	12,079
	10 20 30 40 50 60 MASNVTDKSF EEEVLKSDLP VLVDFWAEWC SPCRMLTPII EEISKDLESK VKVLKMNIDE 70 80 90 100 NPEIPSKYGI RSIPTVMLFK NGEQKDTKVG LHQKNSLIEW INNNI

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000087 Genomic DNA. Translation: ABE04083.1. Different initiation.
RefSeq	YP_537172.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RKN1.
Genome annotation databases
GeneID	3996154.
GenomeReviews	Gene locus RBE_0002 in contig CP000087_GR.
KEGG	rbe:RBE_0002.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1RKN1.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0002-MON.
Family and domain databases
InterPro	IPR005746. Thioredoxin. IPR017936. Thioredoxin-like. IPR012336. Thioredoxin-like_fold. IPR006662. Thioredoxin-like_subdom. IPR015467. Thioredoxin_core. IPR013766. Thioredoxin_domain. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR10438. Trx. 1 hit.
Pfam	PF00085. Thioredoxin. 1 hit. [Graphical view]
PRINTS	PR00421. THIOREDOXIN.
TIGRFAMs	TIGR01068. thioredoxin. 1 hit.
PROSITE	PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THIO_RICBR

Accession

Primary (citable) accession number: Q1RKN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	November 24, 2009
This is version 24 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)