Q1RKM3 (PGSA_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
EC=2.7.8.5

Alternative name(s):
Phosphatidylglycerophosphate synthase
Short name=PGP synthase

Gene names

Name:	pgsA
Ordered Locus Names:	RBE_0010

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity.
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase		PRO_0000281053
Regions
	Transmembrane	8 – 28	21	Helical; Potential
	Transmembrane	35 – 55	21	Helical; Potential
	Transmembrane	64 – 84	21	Helical; Potential
	Transmembrane	148 – 168	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1RKM3 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 56CE206445AF689D	FASTA	181	20,156
	10 20 30 40 50 60 MKIDENLPNY LTIARIAAIP VIILTFYINS PLARMLGALL FVLASITDFF DGYIARKYNL 70 80 90 100 110 120 VTSFGKMLDP IADKLLVGCV IIMLLKKSDV DEIPCLLILA REFLVSGLRE FLALVKVSVP 130 140 150 160 170 180 VSTLAKTKTF LQMFALSILV LGSKGSNIIY LDLVGEIILW IAAFLTIITG YSYFKACKKY F

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04091.1.
RefSeq	YP_537180.1. NC_007940.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RKM3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3996113.
GenomeReviews	Gene locus RBE_0010 in contig CP000087_GR.
KEGG	rbe:RBE_0010.
PATRIC	17881249. VBIRicBel102610_0010.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0558.
HOGENOM	HBG686655.
OMA	WSYMAAS.
ProtClustDB	CLSK870720.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0010-MONOMER.
Family and domain databases
InterPro	IPR000462. CDP-OH_P_trans. IPR004570. Phosphatidylglycerol_P_synth. [Graphical view]
KO	K00995.
Pfam	PF01066. CDP-OH_P_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMs	TIGR00560. PgsA. 1 hit.
PROSITE	PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGSA_RICBR

Accession

Primary (citable) accession number: Q1RKM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program