Q1RKM2 (YIDC_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane protein insertase YidC

Alternative name(s):
Foldase YidC
Membrane integrase YidC
Membrane protein YidC

Gene names

Name:	yidC
Ordered Locus Names:	RBE_0011

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	559 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins By similarity.
Subunit structure	Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01810.
Sequence similarities	Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein insertion into membrane Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 559	559	Membrane protein insertase YidC		PRO_0000272370
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	332 – 352	21	Helical; Potential
	Transmembrane	355 – 375	21	Helical; Potential
	Transmembrane	429 – 449	21	Helical; Potential
	Transmembrane	474 – 494	21	Helical; Potential
	Transmembrane	520 – 540	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1RKM2 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 3461BD06836255DF	FASTA	559	64,229
	10 20 30 40 50 60 MNNNIVNLVA AIVLSLGIIF GWQYFIVKPQ QQKQQQQIAL QKAKDLKKKE SAQLEATPVI 70 80 90 100 110 120 VQEASQAPRI KIDSNALSGS ISLKGLRFDD LILKKYKQDL SENSPEVVLF SPSDTKDAYF 130 140 150 160 170 180 AEIGWVSNLS SVKLPNNETI WNSDSEILTP EKPVNLFWVN EDGVKFLVAI TVDENYLFTI 190 200 210 220 230 240 EQTIVNNSNQ ELPVQSYGLI NRKYTAVEKA VNILHQGPIG CIDENLKEYS YDDIKDKKSE 250 260 270 280 290 300 KFSASKVDWI GITDKYWLTS LIPDKSSNYS SNFNYAVKQE VERYQVDFIS PVQIVKPGEN 310 320 330 340 350 360 FSIKGRLFAG AKKVDLLDKY EKQYDIKLFD RAIDFGWFYI ITKPVFYAMN FFYKYVGNFG 370 380 390 400 410 420 ISILIVTVII KLLMFTLANK SYRSMKRMKN LQPEINRIKN LYGDDKARLN QEIMALYKKE 430 440 450 460 470 480 KVNPVAGCLP ILVQIPVFFS IYKVLYVTIE MRQAPFYGWI KDLSAPDPTS IFNLFGLLHF 490 500 510 520 530 540 SLPSFLMIGA WPILMAITMF LQQRMSPEPA DPVQAQVMKF MPLVFLVMFS SFPAGLLIYW 550 SWNNILSIIQ QYYINKLDK

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04092.1.
RefSeq	YP_537181.1. NC_007940.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RKM2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3996114.
GenomeReviews	Gene locus RBE_0011 in contig CP000087_GR.
KEGG	rbe:RBE_0011.
PATRIC	17881251. VBIRicBel102610_0011.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0706.
HOGENOM	HBG507812.
OMA	FVTIEMR.
ProtClustDB	PRK01318.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0011-MONOMER.
Family and domain databases
HAMAP	MF_01810. YidC_type1. [Tree]
InterPro	IPR019998. Membr_insert_OxaA/YidC_bac. IPR001708. Membrane_insertion_OxaA/YidC. [Graphical view]
KO	K03217.
PANTHER	PTHR12428. Innermemb_insert. 1 hit.
Pfam	PF02096. 60KD_IMP. 1 hit. [Graphical view]
PRINTS	PR00701. 60KDINNERMP. PR01900. YIDCPROTEIN.
TIGRFAMs	TIGR03593. YidC_nterm. 1 hit. TIGR03592. YidC_oxa1_C. 1 hit.
ProtoNet	Search...

Entry information

Entry name

YIDC_RICBR

Accession

Primary (citable) accession number: Q1RKM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program