ID   SAM_RICBR               Reviewed;         291 AA.
AC   Q1RKL2;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   27-MAR-2024, entry version 93.
DE   RecName: Full=S-adenosylmethionine uptake transporter;
GN   Name=sam; OrderedLocusNames=RBE_0021;
OS   Rickettsia bellii (strain RML369-C).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX   NCBI_TaxID=336407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RML369-C;
RX   PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA   Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA   Fournier P.-E., Claverie J.-M., Raoult D.;
RT   "Genome sequence of Rickettsia bellii illuminates the role of amoebae in
RT   gene exchanges between intracellular pathogens.";
RL   PLoS Genet. 2:733-744(2006).
CC   -!- FUNCTION: Transports S-adenosylmethionine. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family.
CC       {ECO:0000305}.
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DR   EMBL; CP000087; ABE04102.1; -; Genomic_DNA.
DR   RefSeq; WP_011476717.1; NC_007940.1.
DR   AlphaFoldDB; Q1RKL2; -.
DR   SMR; Q1RKL2; -.
DR   KEGG; rbe:RBE_0021; -.
DR   eggNOG; COG0697; Bacteria.
DR   HOGENOM; CLU_032828_0_0_5; -.
DR   OrthoDB; 9812899at2; -.
DR   Proteomes; UP000001951; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000620; EamA_dom.
DR   PANTHER; PTHR22911; ACYL-MALONYL CONDENSING ENZYME-RELATED; 1.
DR   PANTHER; PTHR22911:SF6; RH69884P; 1.
DR   Pfam; PF00892; EamA; 2.
DR   SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 2.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..291
FT                   /note="S-adenosylmethionine uptake transporter"
FT                   /id="PRO_0000280994"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          21..141
FT                   /note="EamA 1"
FT   DOMAIN          160..280
FT                   /note="EamA 2"
SQ   SEQUENCE   291 AA;  32591 MW;  88DDA7CFB46BF997 CRC64;
     MNDALKTYSI GIGWFLLSLV SSSANDVMSK YLGTRLHSFE VAFFRFFFSS IVLLPFVVYY
     GKNTLKTSRP FVHILRGLLL FFGMTSWTYG LSIAPVTTAT VISFSIPLFT LILAVFFLNE
     NIIWQRWVVT IVGFVGLVIT LKPHAEDFNP EMLYFVLAAI SFAMLDIINK KFVVKESMIS
     MLFYSAIVTA VVSIPAAANY WLTPTLFELA LLFILGSSGS LILFLLLKAF SMVDATATAP
     YRYLELVISA IAAYFIFNEF PDKSTLHGAV IIIPATLFII YSEKKAMSKK I
//