Reviewed, UniProtKB/Swiss-Prot Q1RKL2 (SAM_RICBR)

Names and origin

Protein names

Recommended name:
    S-adenosylmethionine uptake transporter

Gene names

Name:	sam
Ordered Locus Names:	RBE_0021

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Transports S-adenosylmethionine By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (TC 2.A.7.3) family. [View classification]

Ontologies

Keywords
Biological process	Amino-acid transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	amino acid transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	S-adenosylmethionine uptake transporter		PRO_0000280994
Regions
	Transmembrane	4 – 24	21	Potential
	Transmembrane	41 – 61	21	Potential
	Transmembrane	74 – 91	18	Potential
	Transmembrane	98 – 118	21	Potential
	Transmembrane	121 – 141	21	Potential
	Transmembrane	148 – 168	21	Potential
	Transmembrane	178 – 198	21	Potential
	Transmembrane	206 – 226	21	Potential
	Transmembrane	237 – 257	21	Potential
	Transmembrane	260 – 280	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1RKL2-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 88DDA7CFB46BF997	FASTA	291	32,591
	10 20 30 40 50 60 MNDALKTYSI GIGWFLLSLV SSSANDVMSK YLGTRLHSFE VAFFRFFFSS IVLLPFVVYY 70 80 90 100 110 120 GKNTLKTSRP FVHILRGLLL FFGMTSWTYG LSIAPVTTAT VISFSIPLFT LILAVFFLNE 130 140 150 160 170 180 NIIWQRWVVT IVGFVGLVIT LKPHAEDFNP EMLYFVLAAI SFAMLDIINK KFVVKESMIS 190 200 210 220 230 240 MLFYSAIVTA VVSIPAAANY WLTPTLFELA LLFILGSSGS LILFLLLKAF SMVDATATAP 250 260 270 280 290 YRYLELVISA IAAYFIFNEF PDKSTLHGAV IIIPATLFII YSEKKAMSKK I

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000087 Genomic DNA. Translation: ABE04102.1.
RefSeq	YP_537191.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RKL2.
Genome annotation databases
GeneID	3996098.
GenomeReviews	Gene locus RBE_0021 in contig CP000087_GR.
KEGG	rbe:RBE_0021.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1RKL2.
OMA	PVASQYW
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0021-MON.
Family and domain databases
InterPro	IPR000620. DUF6_TM. [Graphical view]
Pfam	PF00892. DUF6. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SAM_RICBR

Accession

Primary (citable) accession number: Q1RKL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	May 16, 2006
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)