Q1RKL2 (SAM_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
S-adenosylmethionine uptake transporter

Gene names

Name:	sam
Ordered Locus Names:	RBE_0021

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › belli group › Rickettsia bellii

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transports S-adenosylmethionine By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family. [View classification] Contains 2 EamA domains.

Ontologies

Keywords
Biological process	Amino-acid transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	amino acid transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	S-adenosylmethionine uptake transporter		PRO_0000280994
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	41 – 61	21	Helical; Potential
	Transmembrane	74 – 91	18	Helical; Potential
	Transmembrane	98 – 118	21	Helical; Potential
	Transmembrane	121 – 141	21	Helical; Potential
	Transmembrane	148 – 168	21	Helical; Potential
	Transmembrane	178 – 198	21	Helical; Potential
	Transmembrane	206 – 226	21	Helical; Potential
	Transmembrane	237 – 257	21	Helical; Potential
	Transmembrane	260 – 280	21	Helical; Potential
	Domain	21 – 141	121	EamA 1
	Domain	160 – 280	121	EamA 2

Sequences

	Sequence		Length	Mass (Da)
	Q1RKL2 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 88DDA7CFB46BF997	FASTA	291	32,591
	10 20 30 40 50 60 MNDALKTYSI GIGWFLLSLV SSSANDVMSK YLGTRLHSFE VAFFRFFFSS IVLLPFVVYY 70 80 90 100 110 120 GKNTLKTSRP FVHILRGLLL FFGMTSWTYG LSIAPVTTAT VISFSIPLFT LILAVFFLNE 130 140 150 160 170 180 NIIWQRWVVT IVGFVGLVIT LKPHAEDFNP EMLYFVLAAI SFAMLDIINK KFVVKESMIS 190 200 210 220 230 240 MLFYSAIVTA VVSIPAAANY WLTPTLFELA LLFILGSSGS LILFLLLKAF SMVDATATAP 250 260 270 280 290 YRYLELVISA IAAYFIFNEF PDKSTLHGAV IIIPATLFII YSEKKAMSKK I

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04102.1.
RefSeq	YP_537191.1. NC_007940.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	336407.RBE_0021.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE04102; ABE04102; RBE_0021.
GeneID	3996098.
KEGG	rbe:RBE_0021.
PATRIC	17881281. VBIRicBel102610_0025.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0697.
HOGENOM	HOG000264283.
KO	K15270.
OMA	MHFLGER.
ProtClustDB	CLSK870734.
Enzyme and pathway databases
BioCyc	RBEL336407:GJCY-22-MONOMER.
Family and domain databases
InterPro	IPR000620. DMT. [Graphical view]
Pfam	PF00892. EamA. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SAM_RICBR

Accession

Primary (citable) accession number: Q1RKL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program