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Q1RKI0 (GREA_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription elongation factor GreA
Alternative name(s):
Transcript cleavage factor GreA
Gene names
Name:greA
Ordered Locus Names:RBE_0053
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length162 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides By similarity. HAMAP-Rule MF_00105

Sequence similarities

Belongs to the GreA/GreB family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   DomainCoiled coil
   LigandDNA-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processregulation of DNA-templated transcription, elongation

Inferred from electronic annotation. Source: InterPro

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 162162Transcription elongation factor GreA HAMAP-Rule MF_00105
PRO_0000277900

Regions

Coiled coil44 – 6926 Potential

Sequences

Sequence LengthMass (Da)Tools
Q1RKI0 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 2D90AA76DC96BC8A

FASTA16218,115
        10         20         30         40         50         60 
MMAKFPITDQ GFEKLEHELK HLKHVERKKV SEDIAEARAH GDLSENAEYE AAREKQAFVE 

        70         80         90        100        110        120 
ARIKHLEDIT ARAEIINVAK LSGDSIKFGA TVVLIDDETE EEVMYHIVGE YEADITKKRV 

       130        140        150        160 
SIASPIAKAL IGKSVGDIVE VMTPGGVKSY EVVTIKYEEL VF 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE04134.1.
RefSeqYP_537223.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RKI0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_0053.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE04134; ABE04134; RBE_0053.
GeneID3995017.
KEGGrbe:RBE_0053.
PATRIC17881349. VBIRicBel102610_0059.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0782.
HOGENOMHOG000241145.
KOK03624.
OMAHAQIIDV.
OrthoDBEOG686NQ9.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-55-MONOMER.

Family and domain databases

Gene3D1.10.287.180. 1 hit.
3.10.50.30. 1 hit.
HAMAPMF_00105. GreA_GreB.
InterProIPR018151. TF_GreA/GreB_CS.
IPR006359. Tscrpt_elong_fac_GreA.
IPR028624. Tscrpt_elong_fac_GreA/B.
IPR001437. Tscrpt_elong_fac_GreA/B_C.
IPR023459. Tscrpt_elong_fac_GreA/B_fam.
IPR022691. Tscrpt_elong_fac_GreA/B_N.
[Graphical view]
PfamPF01272. GreA_GreB. 1 hit.
PF03449. GreA_GreB_N. 1 hit.
[Graphical view]
PIRSFPIRSF006092. GreA_GreB. 1 hit.
SUPFAMSSF46557. SSF46557. 1 hit.
TIGRFAMsTIGR01462. greA. 1 hit.
PROSITEPS00829. GREAB_1. 1 hit.
PS00830. GREAB_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGREA_RICBR
AccessionPrimary (citable) accession number: Q1RKI0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names