Reviewed, UniProtKB/Swiss-Prot Q1RKH7 (RPOD_RICBR)

Names and origin

Protein names

Recommended name:
    RNA polymerase sigma factor rpoD
Alternative name(s):
    Sigma-70

Gene names

Name:	rpoD
Ordered Locus Names:	RBE_0056

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	641 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This is the primary sigma factor of this bacterium.
Sequence similarities	Belongs to the sigma-70 factor family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Sigma factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription initiation Inferred from electronic annotation. Source: InterPro
Molecular function	sigma factor activity Inferred from electronic annotation. Source: UniProtKB-KW transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 641	641	RNA polymerase sigma factor rpoD		PRO_0000286504
Regions
	DNA binding	587 – 606	20	H-T-H motif By similarity
	Motif	416 – 429	14	Polymerase core binding Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1RKH7-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 22CB3B3976E2FBD2	FASTA	641	73,734
	10 20 30 40 50 60 MTNTDNNNLN KIDSLLKKAK SKKGSVTYND INRALPDGTS VEEIDKVMFR FSEAEVDILD 70 80 90 100 110 120 TNEDDAIKID DMEMEEGFKI STNIDHEPED ETEEENIGTT DDPVRLYLKD MGGVDLLTRE 130 140 150 160 170 180 NEVEIAKRIE EGRKTLIAAL CRSPIAMDKF RKWYADLVNE NNMLLRDLID LESNMMHDDE 190 200 210 220 230 240 TSESEDDHNS DHEEEEQDHD HDHEENILSM SKVETQILPN IIERMKKIAF ICEELLIETK 250 260 270 280 290 300 KSFEKSAGPK ILQNSKKYND NLELLISEVS EIHFNSKRTE EILSEMYRIN RDLINKETAF 310 320 330 340 350 360 LKLAEKYGIT RQNFLDEYIG AVINAAWKEK MLKNKKAGWK ELLTKESDYI DQMIAELSAI 370 380 390 400 410 420 EINTGLLVND FKKLVNAIQK SERQTLQAKK DMIEANLRLV ISIAKKYANR GLQFLDLIQE 430 440 450 460 470 480 GNIGLMKAVD KFEYRRGYKF STYATWWIRQ AITRAIADQA RTIRIPVHMI ETINKIIRTS 490 500 510 520 530 540 RQMLNELGYE PTPAEIAARL SMPIDKVRKV MKIAKEPISL ENPVGDGDDN SYLGDFIEDK 550 560 570 580 590 600 NAVAPIDAAI QSNLREVTTR VLATLTPREE RVLRMRFGIG MNTDHTLEEV GQQFKVTRER 610 620 630 640 IRQIESKALR KLQHPIRSKK LNSFRSGGKR GDGNPSDLLE A

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000087 Genomic DNA. Translation: ABE04137.1.
RefSeq	YP_537226.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RKH7.
Genome annotation databases
GeneID	3995020.
GenomeReviews	Gene locus RBE_0056 in contig CP000087_GR.
KEGG	rbe:RBE_0056.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG745096.
OMA	TRENEVE.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0056-MON.
Family and domain databases
InterPro	IPR014284. RNA_pol_sigma-70. IPR000943. RNA_pol_sigma70. IPR009042. RNA_pol_sigma70_r1_2. IPR007627. RNA_pol_sigma70_r2. IPR007624. RNA_pol_sigma70_r3. IPR007630. RNA_pol_sigma70_r4. IPR007631. RNA_pol_sigma_70_non-ess. IPR007127. RNA_pol_sigma_70_r1.1. IPR013325. RNA_pol_sigma_r2. IPR013324. RNA_pol_sigma_r3_r4. IPR012760. RNA_pol_sigma_RpoD_C. IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 2 hits.
Pfam	PF04546. Sigma70_ner. 1 hit. PF03979. Sigma70_r1_1. 1 hit. PF00140. Sigma70_r1_2. 1 hit. PF04542. Sigma70_r2. 1 hit. PF04539. Sigma70_r3. 1 hit. PF04545. Sigma70_r4. 1 hit. [Graphical view]
PRINTS	PR00046. SIGMA70FCT.
PROSITE	PS00715. SIGMA70_1. 1 hit. PS00716. SIGMA70_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RPOD_RICBR

Accession

Primary (citable) accession number: Q1RKH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 16, 2006
Last modified:	December 15, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)