Reviewed, UniProtKB/Swiss-Prot Q1RKF8 (UDG_RICBR)

Names and origin

Protein names

Recommended name:
    UDP-glucose 6-dehydrogenase
      Short name=UDP-Glc dehydrogenase
      Short name=UDP-GlcDH
      Short name=UDPGDH
    EC=1.1.1.22

Gene names

Name:	udg
Ordered Locus Names:	RBE_0075

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.
Pathway	Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.
Sequence similarities	Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro UDP-glucose 6-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	UDP-glucose 6-dehydrogenase		PRO_0000281044
Regions
	Nucleotide binding	2 – 19	18	NAD Potential
Sites
	Active site	260	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1RKF8-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 53410C577FA28771	FASTA	434	48,268
	10 20 30 40 50 60 MNITFIGSGY VGLVSGVMMS YLGHNVTCLD NDEAKISKLN KRILPIYETK LDKYFTQALE 70 80 90 100 110 120 HERLKFTSFY NEELKNTEAV FITVGTPSKA SGEADLSYVY EAIDKISLHI NKDCLIVIKS 130 140 150 160 170 180 TVPPNSCNNI INYLKEKGFS FNVASNPEFL REGNAVEDFL YPDRIVIGVN NKESEDILRK 190 200 210 220 230 240 IYMPLTDNGA ELVITDLVTA ELIKYGSNSF LATKIAFINE MANLCEKIGA DIKNLSKGIG 250 260 270 280 290 300 LDKRIGTAFL NAGPGFGGSC FPKDILALNS IIKNNYIDSK ILEAVIRSNK ERPSLMVDKI 310 320 330 340 350 360 ATLLDEDLKG KNIAVLGLTY KAGTDDVRAS PAIEIIKNLL DKGTYVKAFD PMGLENSQKT 370 380 390 400 410 420 FQNENLLYLD SAIKVCDSSD AIIITTEWSE FQALDWQKIY SLVKTPIIID LRNILKADEV 430 ESIGFRYYTV GSKI

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04156.1.
RefSeq	YP_537245.1.
3D structure databases
SMR	Q1RKF8. Positions 1-432.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RKF8.
Genome annotation databases
GeneID	3994979.
GenomeReviews	Gene locus RBE_0075 in contig CP000087_GR.
KEGG	rbe:RBE_0075.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1004.
HOGENOM	HBG400967.
OMA	LCEKIGA.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0075-MONOMER.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR016040. NAD(P)-bd_dom. IPR017476. Nucleotide_sugar_DH. IPR014027. UDP-Glc/GDP-Man_DH_C. IPR014026. UDP-Glc/GDP-Man_DH_dimer. IPR014028. UDP-Glc/GDP-Man_DH_dimer-bd. IPR001732. UDP-Glc/GDP-Man_DH_N. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit. G3DSA:3.40.50.1870. UDP-Glc/GDP-Man_DH_C. 1 hit.
PANTHER	PTHR11374. UDPG_MGDP_DH_Creg. 1 hit.
Pfam	PF00984. UDPG_MGDP_dh. 1 hit. PF03720. UDPG_MGDP_dh_C. 1 hit. PF03721. UDPG_MGDP_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR03026. NDP-sugDHase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UDG_RICBR

Accession

Primary (citable) accession number: Q1RKF8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	May 16, 2006
Last modified:	February 9, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)