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Q1RKF8 (UDG_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-glucose 6-dehydrogenase
Short name=UDP-Glc dehydrogenase
Short name=UDP-GlcDH
Short name=UDPGDH
EC=1.1.1.22
Gene names
Name:udg
Ordered Locus Names:RBE_0075
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › belli group ›

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathway

Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.

Sequence similarities

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processUDP-glucuronate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

UDP-glucose 6-dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434UDP-glucose 6-dehydrogenase
PRO_0000281044

Regions

Nucleotide binding2 – 1918NAD Potential

Sites

Active site2601 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RKF8 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 53410C577FA28771

FASTA43448,268
        10         20         30         40         50         60 
MNITFIGSGY VGLVSGVMMS YLGHNVTCLD NDEAKISKLN KRILPIYETK LDKYFTQALE 

        70         80         90        100        110        120 
HERLKFTSFY NEELKNTEAV FITVGTPSKA SGEADLSYVY EAIDKISLHI NKDCLIVIKS 

       130        140        150        160        170        180 
TVPPNSCNNI INYLKEKGFS FNVASNPEFL REGNAVEDFL YPDRIVIGVN NKESEDILRK 

       190        200        210        220        230        240 
IYMPLTDNGA ELVITDLVTA ELIKYGSNSF LATKIAFINE MANLCEKIGA DIKNLSKGIG 

       250        260        270        280        290        300 
LDKRIGTAFL NAGPGFGGSC FPKDILALNS IIKNNYIDSK ILEAVIRSNK ERPSLMVDKI 

       310        320        330        340        350        360 
ATLLDEDLKG KNIAVLGLTY KAGTDDVRAS PAIEIIKNLL DKGTYVKAFD PMGLENSQKT 

       370        380        390        400        410        420 
FQNENLLYLD SAIKVCDSSD AIIITTEWSE FQALDWQKIY SLVKTPIIID LRNILKADEV 

       430 
ESIGFRYYTV GSKI

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000087 Genomic DNA. Translation: ABE04156.1.
RefSeqYP_537245.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RKF8.
ModBaseSearch...

Protein-protein interaction databases

STRING336407.RBE_0075.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE04156; ABE04156; RBE_0075.
GeneID3994979.
KEGGrbe:RBE_0075.
PATRIC17881395. VBIRicBel102610_0082.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1004.
HOGENOMHOG000153773.
KOK00012.
OMARNIYSAR.
ProtClustDBCLSK871073.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-77-MONOMER.
UniPathwayUPA00038; UER00491.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. Nucleotide_sugar_DH.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
[Graphical view]
PfamPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
SSF52413. UDP-Glc/GDP-Man_DH_C. 1 hit.
TIGRFAMsTIGR03026. NDP-sugDHase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUDG_RICBR
AccessionPrimary (citable) accession number: Q1RKF8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 16, 2006
Last modified: May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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