Reviewed, UniProtKB/Swiss-Prot Q1RKE8 (NUOJ_RICBR)

Names and origin

Protein names

Recommended name:
    NADH-quinone oxidoreductase subunit J
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit J
    NDH-1 subunit J

Gene names

Name:	nuoJ
Ordered Locus Names:	RBE_0085

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NADH + quinone = NAD+ + quinol.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the complex I subunit 6 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 205	205	NADH-quinone oxidoreductase subunit J		PRO_0000287839
Regions
	Transmembrane	1 – 21	21	Potential
	Transmembrane	26 – 46	21	Potential
	Transmembrane	54 – 74	21	Potential
	Transmembrane	89 – 109	21	Potential
	Transmembrane	142 – 162	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1RKE8-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 3D7E89FB4F060300	FASTA	205	22,951
	10 20 30 40 50 60 MPIFFYLFTT LIIISSLCVV LSKNSVYSVL WLIFAFINGS GLMILLGAEF LAMMLIVIYV 70 80 90 100 110 120 GAVAVLFLFV IMMLDMHFNK AIMQLKEKPI LSIFVSLIMF ADLVVIILLG TKNIHFSSDL 130 140 150 160 170 180 SFAIASDVSN TKAIGKILYT DFMIPFQIAG LILFVAMIGC ITLTLRKRDG VKRQNIAKQL 190 200 SHNKENAVLM TKPLINKGIE NIKYE

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000087 Genomic DNA. Translation: ABE04166.1.
RefSeq	YP_537255.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RKE8.
Genome annotation databases
GeneID	3995076.
GenomeReviews	Gene locus RBE_0085 in contig CP000087_GR.
KEGG	rbe:RBE_0085.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG729722.
OMA	IFFYLFA.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0085-MON.
Family and domain databases
InterPro	IPR001457. NADH_UbQ/plastoQ_OxRdtase_su6. [Graphical view]
Pfam	PF00499. Oxidored_q3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOJ_RICBR

Accession

Primary (citable) accession number: Q1RKE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 16, 2006
Last modified:	December 15, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)