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Q1RKE7 (NUOK_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit K

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit K
NDH-1 subunit K
Gene names
Name:nuoK
Ordered Locus Names:RBE_0086
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length109 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_01456

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_01456

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01456.

Sequence similarities

Belongs to the complex I subunit 4L family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandNAD
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processATP synthesis coupled electron transport

Inferred from electronic annotation. Source: InterPro

transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNADH dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 109109NADH-quinone oxidoreductase subunit K HAMAP-Rule MF_01456
PRO_0000287846

Regions

Transmembrane12 – 3221Helical; Potential
Transmembrane40 – 6021Helical; Potential
Transmembrane72 – 9221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q1RKE7 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 7E60CFE81722BF78

FASTA10912,314
        10         20         30         40         50         60 
MRILNMNEYI GLNHYLILSS LVFTIGMLGL FMHRKNIINI LMSIELMLLA VNINFVAFSV 

        70         80         90        100 
YMQELSGQIF SIIILTIAAA ETSIGLAILL IYFRNKGSIE VTDINQMRG 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE04167.1.
RefSeqYP_537256.1. NC_007940.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_0086.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE04167; ABE04167; RBE_0086.
GeneID3995077.
KEGGrbe:RBE_0086.
PATRIC17881417. VBIRicBel102610_0093.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0713.
HOGENOMHOG000066429.
KOK00340.
OMARVTVDME.
OrthoDBEOG6MSS3R.
ProtClustDBPRK05715.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-88-MONOMER.

Family and domain databases

HAMAPMF_01456. NDH1_NuoK.
InterProIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view]
PANTHERPTHR11434. PTHR11434. 1 hit.
PfamPF00420. Oxidored_q2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOK_RICBR
AccessionPrimary (citable) accession number: Q1RKE7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 16, 2006
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names