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Q1RKE7

- NUOK_RICBR

UniProt

Q1RKE7 - NUOK_RICBR

Protein

NADH-quinone oxidoreductase subunit K

Gene

nuoK

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (quinone) activity Source: UniProtKB-HAMAP
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro
    2. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-88-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit KUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit KUniRule annotation
    NDH-1 subunit KUniRule annotation
    Gene namesi
    Name:nuoKUniRule annotation
    Ordered Locus Names:RBE_0086
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 109109NADH-quinone oxidoreductase subunit KPRO_0000287846Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi336407.RBE_0086.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalUniRule annotationAdd
    BLAST
    Transmembranei40 – 6021HelicalUniRule annotationAdd
    BLAST
    Transmembranei72 – 9221HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 4L family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0713.
    HOGENOMiHOG000066429.
    KOiK00340.
    OMAiVEDINMM.
    OrthoDBiEOG6MSS3R.

    Family and domain databases

    HAMAPiMF_01456. NDH1_NuoK.
    InterProiIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
    [Graphical view]
    PANTHERiPTHR11434. PTHR11434. 1 hit.
    PfamiPF00420. Oxidored_q2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1RKE7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRILNMNEYI GLNHYLILSS LVFTIGMLGL FMHRKNIINI LMSIELMLLA    50
    VNINFVAFSV YMQELSGQIF SIIILTIAAA ETSIGLAILL IYFRNKGSIE 100
    VTDINQMRG 109
    Length:109
    Mass (Da):12,314
    Last modified:May 16, 2006 - v1
    Checksum:i7E60CFE81722BF78
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04167.1.
    RefSeqiWP_011476782.1. NC_007940.1.
    YP_537256.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE04167; ABE04167; RBE_0086.
    GeneIDi3995077.
    KEGGirbe:RBE_0086.
    PATRICi17881417. VBIRicBel102610_0093.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04167.1 .
    RefSeqi WP_011476782.1. NC_007940.1.
    YP_537256.1. NC_007940.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_0086.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE04167 ; ABE04167 ; RBE_0086 .
    GeneIDi 3995077.
    KEGGi rbe:RBE_0086.
    PATRICi 17881417. VBIRicBel102610_0093.

    Phylogenomic databases

    eggNOGi COG0713.
    HOGENOMi HOG000066429.
    KOi K00340.
    OMAi VEDINMM.
    OrthoDBi EOG6MSS3R.

    Enzyme and pathway databases

    BioCyci RBEL336407:GJCY-88-MONOMER.

    Family and domain databases

    HAMAPi MF_01456. NDH1_NuoK.
    InterProi IPR001133. NADH_UbQ_OxRdtase_chain4L/K.
    [Graphical view ]
    PANTHERi PTHR11434. PTHR11434. 1 hit.
    Pfami PF00420. Oxidored_q2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiNUOK_RICBR
    AccessioniPrimary (citable) accession number: Q1RKE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3