Q1RKE7 (NUOK_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH-quinone oxidoreductase subunit K
EC=1.6.99.5

Alternative name(s):
NADH dehydrogenase I subunit K
NDH-1 subunit K

Gene names

Name:	nuoK
Ordered Locus Names:	RBE_0086

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › belli group › Rickettsia bellii

Protein attributes

Sequence length	109 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_01456
Catalytic activity	NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_01456
Subunit structure	NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01456.
Sequence similarities	Belongs to the complex I subunit 4L family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP synthesis coupled electron transport Inferred from electronic annotation. Source: InterPro photosynthesis, light reaction Inferred from electronic annotation. Source: HAMAP transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	NADH dehydrogenase (quinone) activity Inferred from electronic annotation. Source: HAMAP quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 109	109	NADH-quinone oxidoreductase subunit K HAMAP-Rule MF_01456		PRO_0000287846
Regions
	Transmembrane	12 – 32	21	Helical; Potential
	Transmembrane	40 – 60	21	Helical; Potential
	Transmembrane	72 – 92	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1RKE7 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 7E60CFE81722BF78	FASTA	109	12,314
	10 20 30 40 50 60 MRILNMNEYI GLNHYLILSS LVFTIGMLGL FMHRKNIINI LMSIELMLLA VNINFVAFSV 70 80 90 100 YMQELSGQIF SIIILTIAAA ETSIGLAILL IYFRNKGSIE VTDINQMRG

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04167.1.
RefSeq	YP_537256.1. NC_007940.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	336407.RBE_0086.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE04167; ABE04167; RBE_0086.
GeneID	3995077.
KEGG	rbe:RBE_0086.
PATRIC	17881417. VBIRicBel102610_0093.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0713.
HOGENOM	HOG000066429.
KO	K00340.
OMA	RVTVDME.
ProtClustDB	PRK05715.
Enzyme and pathway databases
BioCyc	RBEL336407:GJCY-88-MONOMER.
Family and domain databases
HAMAP	MF_01456. NDH1_NuoK.
InterPro	IPR001133. NADH_UbQ_OxRdtase_chain4L/K. [Graphical view]
PANTHER	PTHR11434. PTHR11434. 1 hit.
Pfam	PF00420. Oxidored_q2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOK_RICBR

Accession

Primary (citable) accession number: Q1RKE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program