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Reviewed, UniProtKB/Swiss-Prot Q1RKE6 (NUOL_RICBR)

Last modified November 3, 2009. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    NADH-quinone oxidoreductase subunit L
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit L
    NDH-1 subunit L
Gene names
Name: nuoL
Ordered Locus Names: RBE_0087
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsia

Protein attributes

Sequence length642 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.

Catalytic activity

NADH + quinone = NAD+ + quinol.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the complex I subunit 5 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   LigandNAD
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processATP synthesis coupled electron transport

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: InterPro

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 642642NADH-quinone oxidoreductase subunit L
PRO_0000287835

Regions

Transmembrane4 – 2421 Potential
Transmembrane31 – 5121 Potential
Transmembrane88 – 10821 Potential
Transmembrane114 – 13421 Potential
Transmembrane137 – 15721 Potential
Transmembrane171 – 19121 Potential
Transmembrane213 – 23321 Potential
Transmembrane255 – 27521 Potential
Transmembrane287 – 30721 Potential
Transmembrane315 – 33521 Potential
Transmembrane340 – 36021 Potential
Transmembrane383 – 40321 Potential
Transmembrane418 – 43821 Potential
Transmembrane467 – 48721 Potential
Transmembrane513 – 53321 Potential
Transmembrane622 – 64221 Potential

Sequences

Sequence LengthMass (Da)Tools
Q1RKE6-1 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: EEB9B220C02E6A66

FASTA64271,911
        10         20         30         40         50         60 
MYKSIAIMII LLPLASALIN GLFVRRIDKK LASIVATSFL SLSALFALII FYHTGLNGHI 

        70         80         90        100        110        120 
IHIKLLPWIE VSQFKVDWSI YIDQLTSIMF IAVTWVSSVV HIYSLGYMSR DKGIVRFLSF 

       130        140        150        160        170        180 
LSLFTFFMLM LVSADNFLQL FFGWEGVGIC SYLLIGFWYS KESANKAAIK AFIANRVGDF 

       190        200        210        220        230        240 
AFILGVITII FYCHSANYED VFLLAPKLAN TKILLADFEI SILDIACLLL FIGCMGKSAQ 

       250        260        270        280        290        300 
IGLHVWLPDA MEGPTPVSAL IHAATMVTAG VFLVARCSYL FEYSPMVLQF ITIIGGITCL 

       310        320        330        340        350        360 
FAASIAIMQN DIKKIIAYST CSQLGYMFMA CGVSAYNSGI FHLVTHAFFK ALLFLSAGSV 

       370        380        390        400        410        420 
IHAVHEQDIF KMGELRNKMP ITYGNFLIGS LALIGIYPLA GFYSKDSILE AAYSSGSFMF 

       430        440        450        460        470        480 
IFGILAAILT AIYSMKIIML VFHGKTRLEK DVFEHAHEPP KVMNNPLTLL VAGSFFSGMI 

       490        500        510        520        530        540 
GYYLLSMDKP NGYFHDSLLN LHAYKLLITH PPLHIKLLPM VVGIIGIVVG IYLYKSDVVM 

       550        560        570        580        590        600 
SFLRRQESSK DNYFTKILIN KYYFDELYNF LIVKPINCLA CLFYSGDQKI IDRFGPNGFA 

       610        620        630        640 
RSVNCFSRLT GKTQTGYVFN YTLYVVLFVV VTISYFVWLV AV 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

CP000087 Genomic DNA. Translation: ABE04168.1.
RefSeqYP_537257.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ1RKE6.

Genome annotation databases

GeneID3995078.
GenomeReviewsGene locus RBE_0087 in contig CP000087_GR.
KEGGrbe:RBE_0087.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ1RKE6.
OMAKLLPMAV

Enzyme and pathway databases

BioCycRBEL336407:RBE_0087-MON.

Family and domain databases

InterProIPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003916. NADH_UbQ_OxRdtase_chain5.
IPR001516. NADH_UbQ_OxRdtase_chain5/L_N.
IPR003945. NADHpl_OxRdtase_5.
IPR018393. NADHpl_OxRdtase_5_sg.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF00662. Oxidored_q1_N. 1 hit.
[Graphical view]
PRINTSPR01434. NADHDHGNASE5.
PR01435. NPOXDRDTASE5.
TIGRFAMsTIGR01974. NDH_I_L. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNUOL_RICBR
AccessionPrimary (citable) accession number: Q1RKE6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 16, 2006
Last modified: November 3, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents