ID   ACON_RICBR              Reviewed;         885 AA.
AC   Q1RKD5;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Aconitate hydratase;
DE            Short=Aconitase;
DE            EC=4.2.1.3;
DE   AltName: Full=Citrate hydro-lyase;
GN   Name=acnA; OrderedLocusNames=RBE_0098;
OS   Rickettsia bellii (strain RML369-C).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia.
OX   NCBI_TaxID=336407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA   Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA   Fournier P.-E., Claverie J.-M., Raoult D.;
RT   "Genome sequence of Rickettsia bellii illuminates the role of amoebae
RT   in gene exchanges between intracellular pathogens.";
RL   PLoS Genet. 2:733-744(2006).
CC   -!- CATALYTIC ACTIVITY: Citrate = isocitrate.
CC   -!- COFACTOR: Binds 1 4Fe-4S cluster per subunit (By similarity).
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC   -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
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DR   EMBL; CP000087; ABE04179.1; -; Genomic_DNA.
DR   RefSeq; YP_537268.1; -.
DR   GeneID; 3995632; -.
DR   GenomeReviews; CP000087_GR; RBE_0098.
DR   KEGG; rbe:RBE_0098; -.
DR   HOGENOM; Q1RKD5; -.
DR   OMA; Q1RKD5; RIKNEML.
DR   BioCyc; RBEL336407:RBE_0098-MON; -.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003994; F:aconitate hydratase activity; IEA:EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR   InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR   InterPro; IPR015937; Aconitase-like_core.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR006249; Aconitase/Fe_reg_prot_2.
DR   InterPro; IPR015934; Aconitase/Fe_reg_prot_2/AcnD.
DR   InterPro; IPR015932; Aconitase/IPMdHydase_lsu_aba_2.
DR   InterPro; IPR018136; Aconitase_4Fe-4S_BS.
DR   InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR   Gene3D; G3DSA:3.30.499.10; Acnase/IPM_dHydase_lsu_aba_1/3; 2.
DR   Gene3D; G3DSA:3.20.19.10; Aconitase/3IPM_dehydase_swvl; 1.
DR   Gene3D; G3DSA:3.40.1060.10; Aconitase/IPMdHydase_lsu_aba_2; 1.
DR   PANTHER; PTHR11670; Aconitase-like_core; 1.
DR   PANTHER; PTHR11670:SF1; Aconitase/Fe_reg_prot_2/AcnD; 1.
DR   Pfam; PF00330; Aconitase; 1.
DR   Pfam; PF00694; Aconitase_C; 1.
DR   PRINTS; PR00415; ACONITASE.
DR   ProDom; PD000511; Aconitase_N; 1.
DR   TIGRFAMs; TIGR01341; aconitase_1; 1.
DR   PROSITE; PS00450; ACONITASE_1; 1.
DR   PROSITE; PS01244; ACONITASE_2; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Complete proteome; Iron; Iron-sulfur; Lyase; Metal-binding;
KW   Tricarboxylic acid cycle.
FT   CHAIN         1    885       Aconitate hydratase.
FT                                /FTId=PRO_0000272342.
FT   METAL       425    425       Iron-sulfur (4Fe-4S) (By similarity).
FT   METAL       491    491       Iron-sulfur (4Fe-4S) (By similarity).
FT   METAL       494    494       Iron-sulfur (4Fe-4S) (By similarity).
SQ   SEQUENCE   885 AA;  97508 MW;  11EBBC6C35DCD29E CRC64;
     MQKMHNSEYL KELSVNNISY KIYDINKAAS DIDLPLKKLP YSLRVLFENV LRTGSKQNLM
     VFKEWLKNKK SDAEIDFMPA RVLMQDFTGV PAIVDLAAMR DAMKKIGGDP LKINPLIPVD
     LVIDHSVSVD SYASGSSFDK NVAMEMRRNI ERYQFLKWGQ QAFNNFKVVP PGTGICHQVN
     LEYLAKVVWH SNGVAYPDSL VGTDSHTTMV NGLSVLGWGV GGIEAEAAML GQPLTMILPE
     VIGVKLTGKL TGTATATDLV LKITEMLRKK KVVGKFVEFY GEGLKAMTIA DRATISNMAP
     EYGATCGFFP IDQETIKYLE LTGRDKEQIK LVEEYAKAQD LWCNFDDAAE YTDILELDLS
     EVTSSLAGPR RPQDRVNLGD VSSGFKKELS TFSSNNISID TKHAVANQNY EIGNGDVVIA
     AITSCTNTSN PSVMIGAALL AKKAIEQGLK VKPWVKTSLA PGSKVVTEYL KSSGLNQYLD
     QLGFNLVGYG CTTCIGNSGP LNPEIEETIN KNGLVVASVL SGNRNFEGRI NPLTKASYLA
     SPILVVAYAL SGSLNIDLTN HPLGKNDKGR DVYLKDIWPS KEEIDKVIAN SINSSMFVEK
     YSDIFSGTKE WQSLEVTSSS NYAWDKSSTY INNPPYFENI GSKNSIKDIK SARILAIFGD
     SITTDHISPA GSISKTSPAA KYLTDHQISP IDFNSYGSRR GNHEVMMRGT FANIRIKNEM
     CKGVEGGFTI NQLKNMQQTI YDAAMDYKAN GVSAVIFAGK EYGSGSSRDW AAKGPQLLGV
     KAVIAESFER IHRSNLVGMG VLPLIFTNNM TRFDLKLDGS ESIDIIGLNE HIKPYNSVKC
     IIKKQNGEMQ TIDLILQIFT DNEINYIKHG SIMHFVVENL KNNHI
//