Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q1RKD2 (NUOG_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit G

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit G
NDH-1 subunit G
Gene names
Name:nuoG
Ordered Locus Names:RBE_0101
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length681 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.

Catalytic activity

NADH + quinone = NAD+ + quinol.

Cofactor

Binds 1 2Fe-2S cluster per subunit By similarity.

Binds 2 4Fe-4S clusters per subunit By similarity.

Sequence similarities

Belongs to the complex I 75 kDa subunit family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S Mo/W bis-MGD-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 681681NADH-quinone oxidoreductase subunit G
PRO_0000287842

Regions

Domain1 – 78782Fe-2S ferredoxin-type
Domain215 – 271574Fe-4S Mo/W bis-MGD-type

Sites

Metal binding341Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding451Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding481Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding621Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding941Iron-sulfur 2 (4Fe-4S); via pros nitrogen By similarity
Metal binding981Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1011Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1071Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1461Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1491Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1521Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1961Iron-sulfur 3 (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RKD2 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 6DC4D413820168B1

FASTA68176,012
        10         20         30         40         50         60 
MIKLTIDGQE IEVSEGTTVY QACTKAGKEI PHFCYHERLK IAGNCRMCLV EMEKSPKPIA 

        70         80         90        100        110        120 
SCAMPVGNGM VIHTDTPMVK KAREGVMEFL LVNHPLDCPI CDQGGECDLQ DQAFRYGKGT 

       130        140        150        160        170        180 
NRFHENKRSI KDKYMGPLIK TAMTRCIQCT RCIRFANDIA GIEEMGAIHR GEHMEVTSYL 

       190        200        210        220        230        240 
EQTLDSEISG NMIDICPVGA LNSKPYAFKA RKWELRHTAS IGVHDAEGSN IRIDSRGDEV 

       250        260        270        280        290        300 
MRVLPRVNEE INEEWLSDKN RFSYDGLKYQ RLDQPYIRKN GKLVSASWDE ALKAIADKIK 

       310        320        330        340        350        360 
SIKPEKITAF AGTLASVEAM FMLKTFLQKI GCNNYNVNQF DYKLDTTQRG NYLFNTTIAG 

       370        380        390        400        410        420 
LEKADLCLLI GANPRQIAPV LNSRIGGRVR AGSLKVARIG EGHNQTYKIQ DLGSDLKILE 

       430        440        450        460        470        480 
ELALDEHKFA EELKAAKYPI IIVGDGVYGR NDGHAILSLI HKIVDKYNIM RDDWKGFNIL 

       490        500        510        520        530        540 
HNHASMVGGF DIGFDTSLGK LEDIELAYLL GADELPFDKL KSAFIVYQGH HGDIGATKAD 

       550        560        570        580        590        600 
IILPSAAYTE QSGIYVNLEG RPQIAEKAVS PVGKAKEDIA IIKELADCLK LDTLVSNLQE 

       610        620        630        640        650        660 
IRTKLAKEYP IFANIGKIID NKFAKFSSKD KLSKEPITAE TINYYMTDVI SKNSVTMARC 

       670        680 
VEAKQEMSSR GLSTGSRKKR E 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE04182.1.
RefSeqYP_537271.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RKD2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_0101.

Proteomic databases

PRIDEQ1RKD2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE04182; ABE04182; RBE_0101.
GeneID3995635.
KEGGrbe:RBE_0101.
PATRIC17881458. VBIRicBel102610_0113.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1034.
HOGENOMHOG000031442.
KOK00336.
OMAMPVMKGM.
OrthoDBEOG6CVV7G.
ProtClustDBPRK09130.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-103-MONOMER.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR012675. Beta-grasp_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS.
IPR010228. NADH_UbQ_OxRdtase_Gsu.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
IPR015405. NuoG_C.
[Graphical view]
PfamPF09326. DUF1982. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SMARTSM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMSSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR01973. NuoG. 1 hit.
PROSITEPS51085. 2FE2S_FER_2. 1 hit.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00641. COMPLEX1_75K_1. 1 hit.
PS00642. COMPLEX1_75K_2. 1 hit.
PS00643. COMPLEX1_75K_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOG_RICBR
AccessionPrimary (citable) accession number: Q1RKD2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 16, 2006
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names