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Q1RKD2

- NUOG_RICBR

UniProt

Q1RKD2 - NUOG_RICBR

Protein

NADH-quinone oxidoreductase subunit G

Gene

nuoG

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.By similarity

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.

    Cofactori

    Binds 1 2Fe-2S cluster per subunit.By similarity
    Binds 2 4Fe-4S clusters per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi34 – 341Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi45 – 451Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi48 – 481Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi62 – 621Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi94 – 941Iron-sulfur 2 (4Fe-4S); via pros nitrogenBy similarity
    Metal bindingi98 – 981Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi101 – 1011Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi107 – 1071Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi146 – 1461Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi149 – 1491Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi152 – 1521Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi196 – 1961Iron-sulfur 3 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. electron carrier activity Source: InterPro
    4. metal ion binding Source: UniProtKB-KW
    5. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    6. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-103-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit G (EC:1.6.99.5)
    Alternative name(s):
    NADH dehydrogenase I subunit G
    NDH-1 subunit G
    Gene namesi
    Name:nuoG
    Ordered Locus Names:RBE_0101
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 681681NADH-quinone oxidoreductase subunit GPRO_0000287842Add
    BLAST

    Keywords - PTMi

    Quinone

    Proteomic databases

    PRIDEiQ1RKD2.

    Interactioni

    Protein-protein interaction databases

    STRINGi336407.RBE_0101.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RKD2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 78782Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini215 – 271574Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the complex I 75 kDa subunit family.Curated
    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 4Fe-4S Mo/W bis-MGD-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1034.
    HOGENOMiHOG000031442.
    KOiK00336.
    OMAiFQGNDVA.
    OrthoDBiEOG6CVV7G.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR012675. Beta-grasp_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS.
    IPR010228. NADH_UbQ_OxRdtase_Gsu.
    IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
    IPR015405. NuoG_C.
    [Graphical view]
    PfamiPF09326. DUF1982. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF10588. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view]
    SMARTiSM00929. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR01973. NuoG. 1 hit.
    PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
    PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00641. COMPLEX1_75K_1. 1 hit.
    PS00642. COMPLEX1_75K_2. 1 hit.
    PS00643. COMPLEX1_75K_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1RKD2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKLTIDGQE IEVSEGTTVY QACTKAGKEI PHFCYHERLK IAGNCRMCLV    50
    EMEKSPKPIA SCAMPVGNGM VIHTDTPMVK KAREGVMEFL LVNHPLDCPI 100
    CDQGGECDLQ DQAFRYGKGT NRFHENKRSI KDKYMGPLIK TAMTRCIQCT 150
    RCIRFANDIA GIEEMGAIHR GEHMEVTSYL EQTLDSEISG NMIDICPVGA 200
    LNSKPYAFKA RKWELRHTAS IGVHDAEGSN IRIDSRGDEV MRVLPRVNEE 250
    INEEWLSDKN RFSYDGLKYQ RLDQPYIRKN GKLVSASWDE ALKAIADKIK 300
    SIKPEKITAF AGTLASVEAM FMLKTFLQKI GCNNYNVNQF DYKLDTTQRG 350
    NYLFNTTIAG LEKADLCLLI GANPRQIAPV LNSRIGGRVR AGSLKVARIG 400
    EGHNQTYKIQ DLGSDLKILE ELALDEHKFA EELKAAKYPI IIVGDGVYGR 450
    NDGHAILSLI HKIVDKYNIM RDDWKGFNIL HNHASMVGGF DIGFDTSLGK 500
    LEDIELAYLL GADELPFDKL KSAFIVYQGH HGDIGATKAD IILPSAAYTE 550
    QSGIYVNLEG RPQIAEKAVS PVGKAKEDIA IIKELADCLK LDTLVSNLQE 600
    IRTKLAKEYP IFANIGKIID NKFAKFSSKD KLSKEPITAE TINYYMTDVI 650
    SKNSVTMARC VEAKQEMSSR GLSTGSRKKR E 681
    Length:681
    Mass (Da):76,012
    Last modified:May 16, 2006 - v1
    Checksum:i6DC4D413820168B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04182.1.
    RefSeqiWP_011476797.1. NC_007940.1.
    YP_537271.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE04182; ABE04182; RBE_0101.
    GeneIDi3995635.
    KEGGirbe:RBE_0101.
    PATRICi17881458. VBIRicBel102610_0113.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE04182.1 .
    RefSeqi WP_011476797.1. NC_007940.1.
    YP_537271.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RKD2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_0101.

    Proteomic databases

    PRIDEi Q1RKD2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE04182 ; ABE04182 ; RBE_0101 .
    GeneIDi 3995635.
    KEGGi rbe:RBE_0101.
    PATRICi 17881458. VBIRicBel102610_0113.

    Phylogenomic databases

    eggNOGi COG1034.
    HOGENOMi HOG000031442.
    KOi K00336.
    OMAi FQGNDVA.
    OrthoDBi EOG6CVV7G.

    Enzyme and pathway databases

    BioCyci RBEL336407:GJCY-103-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR012675. Beta-grasp_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS.
    IPR010228. NADH_UbQ_OxRdtase_Gsu.
    IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
    IPR015405. NuoG_C.
    [Graphical view ]
    Pfami PF09326. DUF1982. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF10588. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view ]
    SMARTi SM00929. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR01973. NuoG. 1 hit.
    PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
    PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00641. COMPLEX1_75K_1. 1 hit.
    PS00642. COMPLEX1_75K_2. 1 hit.
    PS00643. COMPLEX1_75K_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiNUOG_RICBR
    AccessioniPrimary (citable) accession number: Q1RKD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3