NADH-quinone oxidoreductase subunit G - Rickettsia bellii (strain RML369-C)

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Q1RKD2 (NUOG_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 51. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
NADH-quinone oxidoreductase subunit G
EC=1.6.99.5

Alternative name(s):
NADH dehydrogenase I subunit G
NDH-1 subunit G

Gene names

Name:	nuoG
Ordered Locus Names:	RBE_0101

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › belli group ›

Protein attributes

Sequence length	681 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NADH + quinone = NAD⁺ + quinol.
Cofactor	Binds 1 2Fe-2S cluster per subunit By similarity. Binds 2 4Fe-4S clusters per subunit By similarity.
Sequence similarities	Belongs to the complex I 75 kDa subunit family. Contains 1 2Fe-2S ferredoxin-type domain.

Ontologies

Keywords
Ligand	2Fe-2S 4Fe-4S Iron Iron-sulfur Metal-binding NAD
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP synthesis coupled electron transport Inferred from electronic annotation. Source: InterPro
Cellular_component	membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 681

681

NADH-quinone oxidoreductase subunit G

PRO_0000287842

Regions

Domain

1 – 78

2Fe-2S ferredoxin-type

Sites

Metal binding

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

Iron-sulfur 2 (4Fe-4S); via pros nitrogen By similarity

Metal binding

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

101

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

107

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

146

Iron-sulfur 3 (4Fe-4S) By similarity

Metal binding

149

Iron-sulfur 3 (4Fe-4S) By similarity

Metal binding

152

Iron-sulfur 3 (4Fe-4S) By similarity

Metal binding

196

Iron-sulfur 3 (4Fe-4S) By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q1RKD2 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 6DC4D413820168B1
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FASTA

681

76,012

        10         20         30         40         50         60 
MIKLTIDGQE IEVSEGTTVY QACTKAGKEI PHFCYHERLK IAGNCRMCLV EMEKSPKPIA 

        70         80         90        100        110        120 
SCAMPVGNGM VIHTDTPMVK KAREGVMEFL LVNHPLDCPI CDQGGECDLQ DQAFRYGKGT 

       130        140        150        160        170        180 
NRFHENKRSI KDKYMGPLIK TAMTRCIQCT RCIRFANDIA GIEEMGAIHR GEHMEVTSYL 

       190        200        210        220        230        240 
EQTLDSEISG NMIDICPVGA LNSKPYAFKA RKWELRHTAS IGVHDAEGSN IRIDSRGDEV 

       250        260        270        280        290        300 
MRVLPRVNEE INEEWLSDKN RFSYDGLKYQ RLDQPYIRKN GKLVSASWDE ALKAIADKIK 

       310        320        330        340        350        360 
SIKPEKITAF AGTLASVEAM FMLKTFLQKI GCNNYNVNQF DYKLDTTQRG NYLFNTTIAG 

       370        380        390        400        410        420 
LEKADLCLLI GANPRQIAPV LNSRIGGRVR AGSLKVARIG EGHNQTYKIQ DLGSDLKILE 

       430        440        450        460        470        480 
ELALDEHKFA EELKAAKYPI IIVGDGVYGR NDGHAILSLI HKIVDKYNIM RDDWKGFNIL 

       490        500        510        520        530        540 
HNHASMVGGF DIGFDTSLGK LEDIELAYLL GADELPFDKL KSAFIVYQGH HGDIGATKAD 

       550        560        570        580        590        600 
IILPSAAYTE QSGIYVNLEG RPQIAEKAVS PVGKAKEDIA IIKELADCLK LDTLVSNLQE 

       610        620        630        640        650        660 
IRTKLAKEYP IFANIGKIID NKFAKFSSKD KLSKEPITAE TINYYMTDVI SKNSVTMARC 

       670        680 
VEAKQEMSSR GLSTGSRKKR E

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References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04182.1.
RefSeq	YP_537271.1. NC_007940.1.
3D structure databases
ProteinModelPortal	Q1RKD2.
ModBase	Search...
Protein-protein interaction databases
STRING	336407.RBE_0101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE04182; ABE04182; RBE_0101.
GeneID	3995635.
KEGG	rbe:RBE_0101.
PATRIC	17881458. VBIRicBel102610_0113.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1034.
HOGENOM	HOG000031442.
KO	K00336.
OMA	DTTQRGN.
ProtClustDB	PRK09130.
Enzyme and pathway databases
BioCyc	RBEL336407:GJCY-103-MONOMER.
Family and domain databases
Gene3D	3.10.20.30. 1 hit.
InterPro	IPR001041. 2Fe-2S_ferredoxin-type. IPR012675. Beta-grasp_dom. IPR006656. Mopterin_OxRdtase. IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS. IPR010228. NADH_UbQ_OxRdtase_Gsu. IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd. IPR015405. NuoG_C. [Graphical view]
Pfam	PF09326. DUF1982. 1 hit. PF00384. Molybdopterin. 1 hit. PF10588. NADH-G_4Fe-4S_3. 1 hit. [Graphical view]
SMART	SM00929. NADH-G_4Fe-4S_3. 1 hit. [Graphical view]
SUPFAM	SSF54292. Ferredoxin. 1 hit.
TIGRFAMs	TIGR01973. NuoG. 1 hit.
PROSITE	PS00197. 2FE2S_FER_1. False negative. PS51085. 2FE2S_FER_2. 1 hit. PS00641. COMPLEX1_75K_1. 1 hit. PS00642. COMPLEX1_75K_2. 1 hit. PS00643. COMPLEX1_75K_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOG_RICBR

Accession

Primary (citable) accession number: Q1RKD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents