Reviewed, UniProtKB/Swiss-Prot Q1RKB7 (FABG_RICBR)

Names and origin

Protein names

Recommended name:
    3-oxoacyl-[acyl-carrier-protein] reductase
    EC=1.1.1.100
Alternative name(s):
    3-ketoacyl-acyl carrier protein reductase

Gene names

Name:	fabG
Ordered Locus Names:	RBE_0116

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-oxoacyl-[acyl-carrier-protein] reductase activity Inferred from electronic annotation. Source: EC NAD or NADH binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	3-oxoacyl-[acyl-carrier-protein] reductase		PRO_0000286631
Regions
	Nucleotide binding	11 – 35	25	NADP By similarity
Sites
	Active site	148	1	Proton acceptor By similarity
	Binding site	135	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1RKB7-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 1DA6D37255B4971B	FASTA	241	25,810
	10 20 30 40 50 60 MIDLSGQTAL ITGASGGIGG AIARQLHKLG SHVIISGSNE EKLKALGNDL KDNYTIKVCN 70 80 90 100 110 120 LTNTEECSNL VAQIEKLDIL VCNAGITKDT LAIRMKNEDF DQVIDINLKA NFILNREAIK 130 140 150 160 170 180 KMMTNRYGRI INITSIVGVS GNPGQANYCA SKAGLIGMTK SLAYEVATRG ITVNAVAPGF 190 200 210 220 230 240 IKSDMTDKLN DEQKEAITRK IPKGTYGMPE DIANAVAFLA SKQSSYITGQ TLHVNGGMLM V

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000087 Genomic DNA. Translation: ABE04197.1.
RefSeq	YP_537286.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RKB7.
Genome annotation databases
GeneID	3994991.
GenomeReviews	Gene locus RBE_0116 in contig CP000087_GR.
KEGG	rbe:RBE_0116.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1RKB7.
OMA	GTREDKL.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0116-MON.
Family and domain databases
InterPro	IPR011284. 3oxo_ACP_reduc. IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
TIGRFAMs	TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABG_RICBR

Accession

Primary (citable) accession number: Q1RKB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 16, 2006
Last modified:	November 3, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)