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Q1RKB7 (FABG_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG

EC=1.1.1.100
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene names
Name:fabG
Ordered Locus Names:RBE_0116
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2412413-oxoacyl-[acyl-carrier-protein] reductase FabG
PRO_0000286631

Regions

Nucleotide binding13 – 164NADP By similarity
Nucleotide binding57 – 582NADP By similarity
Nucleotide binding148 – 1525NADP By similarity

Sites

Active site1481Proton acceptor By similarity
Binding site381NADP By similarity
Binding site831NADP; via carbonyl oxygen By similarity
Binding site1351Substrate By similarity
Binding site1811NADP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RKB7 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 1DA6D37255B4971B

FASTA24125,810
        10         20         30         40         50         60 
MIDLSGQTAL ITGASGGIGG AIARQLHKLG SHVIISGSNE EKLKALGNDL KDNYTIKVCN 

        70         80         90        100        110        120 
LTNTEECSNL VAQIEKLDIL VCNAGITKDT LAIRMKNEDF DQVIDINLKA NFILNREAIK 

       130        140        150        160        170        180 
KMMTNRYGRI INITSIVGVS GNPGQANYCA SKAGLIGMTK SLAYEVATRG ITVNAVAPGF 

       190        200        210        220        230        240 
IKSDMTDKLN DEQKEAITRK IPKGTYGMPE DIANAVAFLA SKQSSYITGQ TLHVNGGMLM 


V 

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References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE04197.1.
RefSeqYP_537286.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RKB7.
SMRQ1RKB7. Positions 7-239.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_0116.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE04197; ABE04197; RBE_0116.
GeneID3994991.
KEGGrbe:RBE_0116.
PATRIC17881498. VBIRicBel102610_0133.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1028.
KOK00059.
OMAASEGPAN.
OrthoDBEOG6N3CR8.
ProtClustDBPRK05653.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-118-MONOMER.
UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABG_RICBR
AccessionPrimary (citable) accession number: Q1RKB7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 16, 2006
Last modified: November 13, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways