Reviewed, UniProtKB/Swiss-Prot Q1RK99 (KGUA_RICBR)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	RBE_0134

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity.
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	Guanylate kinase HAMAP MF_00328		PRO_0000266388
Regions
	Domain	6 – 184	179	Guanylate kinase-like
	Nucleotide binding	13 – 20	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1RK99-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 627EEA3EA40099A1	FASTA	191	21,869
	10 20 30 40 50 60 MTKNKGLIII LSSPSGAGKS SLAKALLEID HNLRLSISAT TRKPRPNEQD GVNYYFKTKV 70 80 90 100 110 120 EFEKLVKQNQ FLEHAKIYDN YYGTPKKHVE NLLNQGLDVL FDIDWQGARS IKQNAVNAVS 130 140 150 160 170 180 IFILPPNLEV LEQRLRNRAA DNEEAIQLRM ASAQAEISHS NEYDHIITND DFNDTIQQIH 190 TIILQERKKR N

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000087 Genomic DNA. Translation: ABE04215.1.
RefSeq	YP_537304.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RK99.
Genome annotation databases
GeneID	3995234.
GenomeReviews	Gene locus RBE_0134 in contig CP000087_GR.
KEGG	rbe:RBE_0134.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG671982.
OMA	EWAEFAG.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0134-MON.
Family and domain databases
HAMAP	MF_00328. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. IPR008145. Guanylt/Ca. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_RICBR

Accession

Primary (citable) accession number: Q1RK99

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	May 16, 2006
Last modified:	December 15, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)