Reviewed, UniProtKB/Swiss-Prot Q1RK92 (TLCE_RICBR)

Names and origin

Protein names

Recommended name:
    ADP,ATP carrier protein 5
Alternative name(s):
    ADP/ATP translocase 5

Gene names

Name:	tlcE
Synonyms:	tlc5
Ordered Locus Names:	RBE_0141

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ADP/ATP translocase tlc family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP:ADP antiporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	ADP,ATP carrier protein 5		PRO_0000286485
Regions
	Transmembrane	21 – 41	21	Potential
	Transmembrane	62 – 82	21	Potential
	Transmembrane	94 – 114	21	Potential
	Transmembrane	149 – 169	21	Potential
	Transmembrane	184 – 204	21	Potential
	Transmembrane	224 – 244	21	Potential
	Transmembrane	287 – 307	21	Potential
	Transmembrane	328 – 348	21	Potential
	Transmembrane	357 – 377	21	Potential
	Transmembrane	381 – 401	21	Potential
	Transmembrane	469 – 489	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1RK92-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: ED6D5604AD7BABF0	FASTA	500	57,123
	10 20 30 40 50 60 MLSTSSSRPF KSKFRAAFWP IYNYELGKFI PMSALMFCIL FNQNILRILK DSILISEISA 70 80 90 100 110 120 EIAGFAKVYC VTPAAALFVI IYAKMINHLT FEKIFYYLTA FFIGFFVLFA FVIYPNIHIF 130 140 150 160 170 180 HVHPDYLADW MERYPHFKWY ISLIGNWGYI VYYSLAELWP NIFYVLLFWQ FANELTTTEE 190 200 210 220 230 240 AKRFYTLFSL FGNSSLILVG FLMMNLSSKE TIVKHFINIS DSKITLVQIS TILVTIVAVI 250 260 270 280 290 300 CCLLIRFISR NVFTNPLFYA KAKSGRSTSE RMGIIKSFKY IVKSKYLWLL LICSAAFGFA 310 320 330 340 350 360 INLVEAVWKA KIKELYPTVN TYAEFNSLYI LWTGVAIMVM TIIGNNVMRM HNWFVAAVIS 370 380 390 400 410 420 PVIIMVTGVL FFVLIVFDQK ILSLFDGAIL MSPLALAVSI GGIQNILAKG TKYSIWDTSR 430 440 450 460 470 480 EMLYIPLDQE LKTKGKAAVD VISAKVGKSS SGLVQSIIFT IIPTATFTSI SPVLMVVFTF 490 500 VCLAWIYAVR KIYFEYQKIA

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000087 Genomic DNA. Translation: ABE04222.1.
RefSeq	YP_537311.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RK92.
Genome annotation databases
GeneID	3995241.
GenomeReviews	Gene locus RBE_0141 in contig CP000087_GR.
KEGG	rbe:RBE_0141.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1RK92.
OMA	MMNLSSE
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0141-MON.
Family and domain databases
InterPro	IPR004667. ADP_ATP_car. [Graphical view]
Pfam	PF03219. TLC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00769. AAA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TLCE_RICBR

Accession

Primary (citable) accession number: Q1RK92

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 16, 2006
Last modified:	November 24, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)