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Protein

DNA translocase FtsK

Gene

ftsK

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi411 – 416ATPPROSITE-ProRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA translocase FtsK
Gene namesi
Name:ftsK
Ordered Locus Names:RBE_0154
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
Proteomesi
  • UP000001951 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 749CytoplasmicSequence analysisAdd BLAST587

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002809661 – 749DNA translocase FtsKAdd BLAST749

Interactioni

Subunit structurei

Homohexamer. Forms a ring that surrounds DNA (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ1RK79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini391 – 610FtsKPROSITE-ProRule annotationAdd BLAST220

Domaini

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity).By similarity

Sequence similaritiesi

Belongs to the FtsK/SpoIIIE/SftA family.Curated
Contains 1 FtsK domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000010003.
KOiK03466.
OMAiIAFNFFE.
OrthoDBiPOG091H01S4.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR025199. FtsK_4TM.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF13491. FtsK_4TM. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RK79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYYVNKFLS NSKVQAVILG IIGLATISML VSYKLDDPSF NSATTGYTNN
60 70 80 90 100
LLGIFGSYLS DFLYQFFGVA AFIIPLSCFI WGKNCWQQKY RKSFIRISVM
110 120 130 140 150
LLALFSTAAL LSNFDLEFVP SNGGGAAGII IFHFLKQFTN QLHLLLVFFT
160 170 180 190 200
FIIFVVLFEI KFTSLSSFII KLGKFLAYKI QTFFYNLFSQ LTLPKLFSGK
210 220 230 240 250
ANNKIKITPS YTKPVNEKIR FTEEPKPIMA KPAPVNPIKF FNKPTVPKIS
260 270 280 290 300
QNDATALPPI SLLRNPENHH IKGASSSELK QKAEELLTVL NDFGVKGQII
310 320 330 340 350
NIGQGPVVTL YEFEPAAGTK TSRVVGLSDD IARSLSALST RIAVVPGKNV
360 370 380 390 400
LGIELPNKQR EFFCLKELIE TPEYQDTSTL LPLVLGKDLA GKPLIADLAK
410 420 430 440 450
MPHLLVAGTT GSGKSVGINA MIVSLLYRYT PEECRFIMID PKMLELSAYD
460 470 480 490 500
GIPHLLTPVV TEPAKAVVAL KWAVKEMENR YRMMSNIGVK NIAGYNTKIQ
510 520 530 540 550
EAVKEGRIIE KSIQTGFDPE TGRPIYETVA MNMEKLPFIA VIVDEMADLM
560 570 580 590 600
LVAGKDIEML IQRLAQMARA AGIHIIMATQ RPSVDVITGV IKANFPSRIS
610 620 630 640 650
FKVTSKIDSR TILGEQGSEQ LLGMGDMLFM GNTSKITRVH GPFVNESEIE
660 670 680 690 700
QITEYLKETG TPEYISAVTE QSDEDDSSID IGDGTSDEVL YKKAVQIVRD
710 720 730 740
ERKSSISYIQ RSLRIGYNKA ANLVEKMEKE GIVSPPNHTG KREILLPER
Length:749
Mass (Da):83,190
Last modified:May 16, 2006 - v1
Checksum:i9F924B945F423F3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04235.1.
RefSeqiWP_011476850.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE04235; ABE04235; RBE_0154.
KEGGirbe:RBE_0154.
PATRICi17881592. VBIRicBel102610_0178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE04235.1.
RefSeqiWP_011476850.1. NC_007940.1.

3D structure databases

ProteinModelPortaliQ1RK79.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE04235; ABE04235; RBE_0154.
KEGGirbe:RBE_0154.
PATRICi17881592. VBIRicBel102610_0178.

Phylogenomic databases

HOGENOMiHOG000010003.
KOiK03466.
OMAiIAFNFFE.
OrthoDBiPOG091H01S4.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR025199. FtsK_4TM.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF13491. FtsK_4TM. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTSK_RICBR
AccessioniPrimary (citable) accession number: Q1RK79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 16, 2006
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.