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Protein

DNA translocase FtsK

Gene

ftsK

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi411 – 416ATPPROSITE-ProRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Chromosome partition
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRBEL336407:G1G4P-225-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA translocase FtsK
Gene namesi
Name:ftsK
Ordered Locus Names:RBE_0154
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
Proteomesi
  • UP000001951 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 749CytoplasmicSequence analysisAdd BLAST587

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002809661 – 749DNA translocase FtsKAdd BLAST749

Proteomic databases

PRIDEiQ1RK79

Interactioni

Subunit structurei

Homohexamer. Forms a ring that surrounds DNA (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ1RK79
SMRiQ1RK79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini391 – 610FtsKPROSITE-ProRule annotationAdd BLAST220

Domaini

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity).By similarity

Sequence similaritiesi

Belongs to the FtsK/SpoIIIE/SftA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000010003
KOiK03466
OMAiRDPENHH
OrthoDBiPOG091H01S4

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR025199 FtsK_4TM
IPR002543 FtsK_dom
IPR018541 Ftsk_gamma
IPR027417 P-loop_NTPase
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF13491 FtsK_4TM, 1 hit
PF09397 Ftsk_gamma, 1 hit
PF01580 FtsK_SpoIIIE, 1 hit
SMARTiView protein in SMART
SM00843 Ftsk_gamma, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50901 FTSK, 1 hit

Sequencei

Sequence statusi: Complete.

Q1RK79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYYVNKFLS NSKVQAVILG IIGLATISML VSYKLDDPSF NSATTGYTNN
60 70 80 90 100
LLGIFGSYLS DFLYQFFGVA AFIIPLSCFI WGKNCWQQKY RKSFIRISVM
110 120 130 140 150
LLALFSTAAL LSNFDLEFVP SNGGGAAGII IFHFLKQFTN QLHLLLVFFT
160 170 180 190 200
FIIFVVLFEI KFTSLSSFII KLGKFLAYKI QTFFYNLFSQ LTLPKLFSGK
210 220 230 240 250
ANNKIKITPS YTKPVNEKIR FTEEPKPIMA KPAPVNPIKF FNKPTVPKIS
260 270 280 290 300
QNDATALPPI SLLRNPENHH IKGASSSELK QKAEELLTVL NDFGVKGQII
310 320 330 340 350
NIGQGPVVTL YEFEPAAGTK TSRVVGLSDD IARSLSALST RIAVVPGKNV
360 370 380 390 400
LGIELPNKQR EFFCLKELIE TPEYQDTSTL LPLVLGKDLA GKPLIADLAK
410 420 430 440 450
MPHLLVAGTT GSGKSVGINA MIVSLLYRYT PEECRFIMID PKMLELSAYD
460 470 480 490 500
GIPHLLTPVV TEPAKAVVAL KWAVKEMENR YRMMSNIGVK NIAGYNTKIQ
510 520 530 540 550
EAVKEGRIIE KSIQTGFDPE TGRPIYETVA MNMEKLPFIA VIVDEMADLM
560 570 580 590 600
LVAGKDIEML IQRLAQMARA AGIHIIMATQ RPSVDVITGV IKANFPSRIS
610 620 630 640 650
FKVTSKIDSR TILGEQGSEQ LLGMGDMLFM GNTSKITRVH GPFVNESEIE
660 670 680 690 700
QITEYLKETG TPEYISAVTE QSDEDDSSID IGDGTSDEVL YKKAVQIVRD
710 720 730 740
ERKSSISYIQ RSLRIGYNKA ANLVEKMEKE GIVSPPNHTG KREILLPER
Length:749
Mass (Da):83,190
Last modified:May 16, 2006 - v1
Checksum:i9F924B945F423F3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA Translation: ABE04235.1
RefSeqiWP_011476850.1, NC_007940.1

Genome annotation databases

EnsemblBacteriaiABE04235; ABE04235; RBE_0154
KEGGirbe:RBE_0154

Similar proteinsi

Entry informationi

Entry nameiFTSK_RICBR
AccessioniPrimary (citable) accession number: Q1RK79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 16, 2006
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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