Q1RK79 (FTSK_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA translocase FtsK

Gene names

Name:	ftsK
Ordered Locus Names:	RBE_0154

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	749 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA motor protein, which is both required to move DNA out of the region of the septum during cell division and for the septum formation. Tracks DNA in an ATP-dependent manner by generating positive supercoils in front of it and negative supercoils behind it By similarity.
Subunit structure	Homohexamer. This suggests the formation of a ring between the two cells at the septum that surrounds DNA By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side. Note: Located at the septum. The large C-terminal part of the protein is cytoplasmic Potential.
Sequence similarities	Contains 1 FtsK domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Chromosome partition
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW chromosome segregation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 749	749	DNA translocase FtsK		PRO_0000280966
Regions
	Transmembrane	13 – 33	21	Helical; Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Transmembrane	99 – 119	21	Helical; Potential
	Transmembrane	142 – 162	21	Helical; Potential
	Domain	391 – 610	220	FtsK
	Nucleotide binding	408 – 415	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1RK79 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 9F924B945F423F3D	FASTA	749	83,190
	10 20 30 40 50 60 MLYYVNKFLS NSKVQAVILG IIGLATISML VSYKLDDPSF NSATTGYTNN LLGIFGSYLS 70 80 90 100 110 120 DFLYQFFGVA AFIIPLSCFI WGKNCWQQKY RKSFIRISVM LLALFSTAAL LSNFDLEFVP 130 140 150 160 170 180 SNGGGAAGII IFHFLKQFTN QLHLLLVFFT FIIFVVLFEI KFTSLSSFII KLGKFLAYKI 190 200 210 220 230 240 QTFFYNLFSQ LTLPKLFSGK ANNKIKITPS YTKPVNEKIR FTEEPKPIMA KPAPVNPIKF 250 260 270 280 290 300 FNKPTVPKIS QNDATALPPI SLLRNPENHH IKGASSSELK QKAEELLTVL NDFGVKGQII 310 320 330 340 350 360 NIGQGPVVTL YEFEPAAGTK TSRVVGLSDD IARSLSALST RIAVVPGKNV LGIELPNKQR 370 380 390 400 410 420 EFFCLKELIE TPEYQDTSTL LPLVLGKDLA GKPLIADLAK MPHLLVAGTT GSGKSVGINA 430 440 450 460 470 480 MIVSLLYRYT PEECRFIMID PKMLELSAYD GIPHLLTPVV TEPAKAVVAL KWAVKEMENR 490 500 510 520 530 540 YRMMSNIGVK NIAGYNTKIQ EAVKEGRIIE KSIQTGFDPE TGRPIYETVA MNMEKLPFIA 550 560 570 580 590 600 VIVDEMADLM LVAGKDIEML IQRLAQMARA AGIHIIMATQ RPSVDVITGV IKANFPSRIS 610 620 630 640 650 660 FKVTSKIDSR TILGEQGSEQ LLGMGDMLFM GNTSKITRVH GPFVNESEIE QITEYLKETG 670 680 690 700 710 720 TPEYISAVTE QSDEDDSSID IGDGTSDEVL YKKAVQIVRD ERKSSISYIQ RSLRIGYNKA 730 740 ANLVEKMEKE GIVSPPNHTG KREILLPER

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04235.1.
RefSeq	YP_537324.1. NC_007940.1.
3D structure databases
ProteinModelPortal	Q1RK79.
SMR	Q1RK79. Positions 257-669.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RK79.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3995155.
GenomeReviews	Gene locus RBE_0154 in contig CP000087_GR.
KEGG	rbe:RBE_0154.
PATRIC	17881592. VBIRicBel102610_0178.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1674.
HOGENOM	HBG662140.
OMA	FVICIND.
ProtClustDB	CLSK871096.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0154-MONOMER.
Family and domain databases
InterPro	IPR002543. Cell_div_FtsK/SpoIIIE. IPR018541. DNA_translocase_Ftsk_gamma. [Graphical view]
KO	K03466.
Pfam	PF09397. Ftsk_gamma. 1 hit. PF01580. FtsK_SpoIIIE. 1 hit. [Graphical view]
SMART	SM00843. Ftsk_gamma. 1 hit. [Graphical view]
PROSITE	PS50901. FTSK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTSK_RICBR

Accession

Primary (citable) accession number: Q1RK79

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program