Q1RK71 (UVRA_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UvrABC system protein A
Short name=UvrA protein

Alternative name(s):
Excinuclease ABC subunit A

Gene names

Name:	uvrA
Ordered Locus Names:	RBE_0162

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	953 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate By similarity. HAMAP MF_00205
Subunit structure	Forms a heterotetramer with UvrB during the search for lesions By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_00205.
Sequence similarities	Belongs to the ABC transporter superfamily. UvrA family. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	DNA damage DNA excision DNA repair SOS response Transport
Cellular component	Cytoplasm
Domain	Repeat Zinc-finger
Ligand	ATP-binding DNA-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Excision nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	SOS response Inferred from electronic annotation. Source: UniProtKB-KW nucleotide-excision repair Inferred from electronic annotation. Source: InterPro transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell excinuclease repair complex Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: UniProtKB-KW excinuclease ABC activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 953	953	UvrABC system protein A HAMAP MF_00205		PRO_0000278041
Regions
	Domain	348 – 599	252	ABC transporter 1
	Domain	610 – 949	340	ABC transporter 2
	Nucleotide binding	33 – 40	8	ATP Potential
	Nucleotide binding	652 – 659	8	ATP Potential
	Zinc finger	752 – 778	27	C4-type HAMAP MF_00205

Sequences

	Sequence		Length	Mass (Da)
	Q1RK71 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 8D7BF227C2EB5448	FASTA	953	106,285
	10 20 30 40 50 60 MNQEYIKVRG AKEHNLKNIN VDIPRNKFVV ITGLSGSGKS SLAFDTIYAE GQRRYVESLS 70 80 90 100 110 120 SYARQFLHLQ NKPNVESISG LSPAIAIDQK TTSKNPRSTV GTITEIYDYL RLLYARVGIP 130 140 150 160 170 180 YSPATGLPIH SQTVSEMVDI INELPQGTKI YLLAPIVRGH KGEFKREIMN LKKQGFQKLI 190 200 210 220 230 240 VNGETCEIDD LPKLDKNKKH NIEVIVDRIV LDENLGNRLA DSLESSLNLA DGITYLEIVE 250 260 270 280 290 300 LPTAANTEYE KNQRITFSEK YSCPVSGFQL TEIEPRIFSF NSPFGACPKC EGIGKEFFFD 310 320 330 340 350 360 RDLIVPDHRI SIKDGAIVPW GSTSSKFILE TLKALAEHYR FSIESPFSAL SDNIKTILFE 370 380 390 400 410 420 GSGEEAIRFE FHDGSKTQVI HQPFAGIIPS LQEKDRTIES VLIKEELAKF KSEHKCTACN 430 440 450 460 470 480 GYRLKDEALC VKIVNIHIGE VADMSIATLQ QWFAHLEQKL NKKQLFIAER ILKEINERLK 490 500 510 520 530 540 FLMNVGLDYL TLSRESGTLS GGESQRIRLA SQIGSGLSGV LYVLDEPSIG LHQRDNTRLI 550 560 570 580 590 600 ETLKRLRDLG NTVLVVEHDE ETMYEADHII DIGPGAGIHG GRVIAEGNAE EIKNFEESIT 610 620 630 640 650 660 GRYLSGRQTI KVPTQTRTGH DNRAIELIGA VSNNLDNVDI KIPLGTFTAI TGVSGSGKSS 670 680 690 700 710 720 LMIHTLYKAA LKHLEPTAKV FPGKYQKLKG LEYIDKIIDI NQSPIGRTPR SNPATYTGAF 730 740 750 760 770 780 THIRDWFVEL PESKARGYKV GRFSFNVKGG RCEACQGDGL IKIEMHFLPD VYVKCDICNG 790 800 810 820 830 840 HRYNRETLEI KYKGKSIADI LMMTVEDAMQ FFEKIPLIYE KLITLNEVGL GYIKIGQSAT 850 860 870 880 890 900 TLSGGEAQRV KLAKELSRRS TGKTLYILDE PTTGLHIDDI NKLLKVLHKL VDMGNTVLVI 910 920 930 940 950 EHNLDVIKTA DYIIDVGPEG GDKGGKIVVH GTPADIAACS ESHTGRYLKQ YLK

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04243.1.
RefSeq	YP_537332.1. NC_007940.1.
3D structure databases
ProteinModelPortal	Q1RK71.
SMR	Q1RK71. Positions 4-953.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RK71.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3994930.
GenomeReviews	Gene locus RBE_0162 in contig CP000087_GR.
KEGG	rbe:RBE_0162.
PATRIC	17881608. VBIRicBel102610_0186.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0178.
HOGENOM	HBG284763.
OMA	GAIKGWD.
ProtClustDB	PRK00349.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0162-MONOMER.
Family and domain databases
HAMAP	MF_00205. UvrA. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR013815. ATP_grasp_subdomain_1. IPR004602. UvrA_ABC. [Graphical view]
Gene3D	G3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 2 hits.
KO	K03701.
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
TIGRFAMs	TIGR00630. Uvra. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UVRA_RICBR

Accession

Primary (citable) accession number: Q1RK71

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program