Reviewed, UniProtKB/Swiss-Prot Q1RK58 (PLD_RICBR)

Names and origin

Protein names

Recommended name:
    Phospholipase D
      Short name=PLD
    EC=3.1.4.4
Alternative name(s):
    Choline phosphatase

Gene names

Name:	pld
Synonyms:	pldA
Ordered Locus Names:	RBE_0175

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Could be a virulence factor By similarity.
Catalytic activity	A phosphatidylcholine + H2O = choline + a phosphatidate.
Subunit structure	Homodimer By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the phospholipase D family. Contains 1 PLD phosphodiesterase domain.

Ontologies

Keywords
Biological process	Lipid degradation Virulence
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAPE-specific phospholipase D activity Inferred from electronic annotation. Source: EC phospholipase D activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 201	176	Phospholipase D		PRO_0000274782
Regions
	Domain	142 – 169	28	PLD phosphodiesterase
Sites
	Active site	147	1	Potential
	Active site	149	1	Potential
	Active site	154	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1RK58-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 79ADA07A9A7B5C78	FASTA	201	22,440
	10 20 30 40 50 60 MKRKNKKFTE IFIAFILGIA IGVLGYSDYG TDLINQFKIS HTPPPKIKHY NISQLSRSKV 70 80 90 100 110 120 STCFTPPSGC TKFIADQIDT ARESIYMHAY GMSDSLITAA LIDAQARGVQ VKILLDRSNL 130 140 150 160 170 180 KQKFSKLHEL QRAKIEVGID KVPGIAHNKV IIIDKKKVIT GSFNFTAAAD KRNAENVIVI 190 200 EDAELADSYL QNWLSRKARN G

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE04256.1.
RefSeq	YP_537345.1.
3D structure databases
SMR	Q1RK58. Positions 58-196.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RK58.
Genome annotation databases
GeneID	3995535.
GenomeReviews	Gene locus RBE_0175 in contig CP000087_GR.
KEGG	rbe:RBE_0175.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1502.
HOGENOM	HBG501643.
OMA	DNQKVIT.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0175-MONOMER.
Family and domain databases
InterPro	IPR001736. PLipase_D/transphosphatidylase. [Graphical view]
SMART	SM00155. PLDc. 1 hit. [Graphical view]
PROSITE	PS50035. PLD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PLD_RICBR

Accession

Primary (citable) accession number: Q1RK58

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	May 16, 2006
Last modified:	January 19, 2010
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)