Reviewed, UniProtKB/Swiss-Prot Q1RK56 (XERC_RICBR)

Names and origin

Protein names

Recommended name:
    Tyrosine recombinase xerC

Gene names

Name:	xerC
Ordered Locus Names:	RBE_0177

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids By similarity.
Subunit structure	Forms a cyclic heterotetrameric complex composed of two molecules of xerC and two molecules of xerD By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the 'phage' integrase family. XerC subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Chromosome partition DNA integration DNA recombination
Cellular component	Cytoplasm
Ligand	DNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA integration Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW chromosome segregation Inferred from electronic annotation. Source: HAMAP transposition, DNA-mediated Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW tyrosine-based site-specific recombinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Tyrosine recombinase xerC HAMAP MF_01808		PRO_0000272365
Sites
	Active site	159	1	By similarity
	Active site	182	1	By similarity
	Active site	250	1	By similarity
	Active site	253	1	By similarity
	Active site	276	1	By similarity
	Active site	285	1	O-(3'-phospho-DNA)-tyrosine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1RK56-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 90B2290F98289409	FASTA	305	35,517
	10 20 30 40 50 60 MLDTQIQELI IKWQKYLSLQ KNYSNHTLIS YNNDLKHFLE FMNYYNSDIV TMDYIKAADI 70 80 90 100 110 120 RLMRSWLAKR KCDNFVTSSI ARGLSAIKNF YKFLEKTAEL HNHVVFSIKS PKKSKLLPKA 130 140 150 160 170 180 LSEEEVNISL DHIEEYGNSQ WIEIRNKALL VLIYASGLRI SEALSITKLH LQNLEFIKIM 190 200 210 220 230 240 GKGSKERVIP WLAIARNLIT EYLEKLPYEL KDDEPIFRGK QGKKLQPPVF NRELIKLKRF 250 260 270 280 290 300 YGLPEYLSAH SFRHSFASHL LENGADLRSI QELLGHKSLS TTQSYTKTSI KHLETAYVTA HPIKK

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000087 Genomic DNA. Translation: ABE04258.1.
RefSeq	YP_537347.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RK56.
Genome annotation databases
GeneID	3995537.
GenomeReviews	Gene locus RBE_0177 in contig CP000087_GR.
KEGG	rbe:RBE_0177.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1RK56.
OMA	VKWVELR
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_0177-MON.
Family and domain databases
HAMAP	MF_01808. [Tree]
InterPro	IPR011010. DNA_brk_join_enz. IPR013762. Integrase-like_cat-core_phage. IPR002104. Integrase_cat-core_phage. IPR010998. Integrase_Lambda-type_N. IPR004107. Integrase_SAM-like_N_phage. [Graphical view]
Gene3D	G3DSA:1.10.443.10. Phage_intgr_like. 1 hit.
Pfam	PF02899. Phage_integr_N. 1 hit. PF00589. Phage_integrase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XERC_RICBR

Accession

Primary (citable) accession number: Q1RK56

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	May 16, 2006
Last modified:	November 24, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)